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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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March 2012 Volume 5 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Endothelin-1 and type III collagen alterations in the heart of rats following cisplatin-induced toxicity

  • Authors:
    • Quan-Yong Huang
    • Xue-Fang Li
    • Shui-Ping Liu

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, School of Basic Medical Sciences, Dali University, Dali, Yunnan 671000, P.R. China, School of Basic Medical Sciences, Dali University, Dali, Yunnan 671000, P.R. China, Department of Forensic Pathology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, P.R. China
  • Pages: 651-654
    |
    Published online on: December 13, 2011
       https://doi.org/10.3892/mmr.2011.706
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Abstract

Cisplatin-induced heart damage is associated with enzymes and protein alterations. The purpose of this study was to investigate cisplatin-induced alterations in cardiac endothelin (ET)-1 and type III collagen following administration of cisplatin. Male Wistar rats were randomly divided into two groups: a control and a cisplatin group. The cisplatin group received cisplatin intraperitoneally (i.p.) at a single dose of 7 mg/kg on day 6, while the controls were given the same amount of saline via the same route. On day 11, the rats were anesthetized and a thoracotomy was performed on all animals. Immunohistochemical analysis was performed to evaluate the protein expression of ET-1 and type III collagen. Sections were analyzed by digital image analysis. Results showed that the cardiac protein expression of ET-1 and type III collagen was altered following cisplatin-induced toxicity in rats. The expression of ET-1 and type III collagen was significantly increased after cisplatin treatment, supported by integrated optical density, when compared to the control group (P<0.05). The present findings indicate that such alterations may be reflected in abnormal cardiac function. Additionally, the proteins identified in this study may benefit investigations into the mechanisms underlying cisplatin-induced toxicity, thereby providing the necessary evidence for further research.

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Copy and paste a formatted citation
Spandidos Publications style
Huang Q, Li X and Liu S: Endothelin-1 and type III collagen alterations in the heart of rats following cisplatin-induced toxicity. Mol Med Rep 5: 651-654, 2012.
APA
Huang, Q., Li, X., & Liu, S. (2012). Endothelin-1 and type III collagen alterations in the heart of rats following cisplatin-induced toxicity. Molecular Medicine Reports, 5, 651-654. https://doi.org/10.3892/mmr.2011.706
MLA
Huang, Q., Li, X., Liu, S."Endothelin-1 and type III collagen alterations in the heart of rats following cisplatin-induced toxicity". Molecular Medicine Reports 5.3 (2012): 651-654.
Chicago
Huang, Q., Li, X., Liu, S."Endothelin-1 and type III collagen alterations in the heart of rats following cisplatin-induced toxicity". Molecular Medicine Reports 5, no. 3 (2012): 651-654. https://doi.org/10.3892/mmr.2011.706
Copy and paste a formatted citation
x
Spandidos Publications style
Huang Q, Li X and Liu S: Endothelin-1 and type III collagen alterations in the heart of rats following cisplatin-induced toxicity. Mol Med Rep 5: 651-654, 2012.
APA
Huang, Q., Li, X., & Liu, S. (2012). Endothelin-1 and type III collagen alterations in the heart of rats following cisplatin-induced toxicity. Molecular Medicine Reports, 5, 651-654. https://doi.org/10.3892/mmr.2011.706
MLA
Huang, Q., Li, X., Liu, S."Endothelin-1 and type III collagen alterations in the heart of rats following cisplatin-induced toxicity". Molecular Medicine Reports 5.3 (2012): 651-654.
Chicago
Huang, Q., Li, X., Liu, S."Endothelin-1 and type III collagen alterations in the heart of rats following cisplatin-induced toxicity". Molecular Medicine Reports 5, no. 3 (2012): 651-654. https://doi.org/10.3892/mmr.2011.706
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