Solitary huge hepatocellular carcinomas 10 cm or larger may be completely ablated by repeated radiofrequency ablation combined with chemoembolization: Initial experience with 9 patients

Ke,Shan; Ding,Xuemei; Gao,Jun; Gao,Kun; Qian,Xiaojun; Cao,Baoxing; Li,Mingying; Sun,Wenbing

doi:10.3892/mmr.2011.708

March 2012 Volume 5 Issue 3

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

March 2012 Volume 5 Issue 3

Full Size Image

Article

Solitary huge hepatocellular carcinomas 10 cm or larger may be completely ablated by repeated radiofrequency ablation combined with chemoembolization: Initial experience with 9 patients

Authors:
- Shan Ke
- Xuemei Ding
- Jun Gao
- Kun Gao
- Xiaojun Qian
- Baoxing Cao
- Mingying Li
- Wenbing Sun
View Affiliations / Copyright

Affiliations: Department of Hepatobiliary Surgery, Beijing Chao-yang Hospital Affiliated to Capital Medical University, Beijing 100043, P.R. China, Department of Interventional Medicine, Beijing Chao-yang Hospital Affiliated to Capital Medical University, Beijing 100043, P.R. China, Department of Radiology, Beijing Chao-yang Hospital Affiliated to Capital Medical University, Beijing 100043, P.R. China, Department of Anesthesiology, Beijing Chao-yang Hospital Affiliated to Capital Medical University, Beijing 100043, P.R. China
Pages: 832-836
|
Published online on: December 13, 2011

https://doi.org/10.3892/mmr.2011.708
Expand metrics +

Abstract

The treatment of solitary huge hepatocellular carcinoma (SHHCC) larger than 10 cm remains a challenge. The aim of the present study was to assess the therapeutic effects of repeated radiofrequency ablation (RFA) combined with chemoembolization on SHHCC. This was a retrospective study based on data obtained from a prospectively collected database that included 9 SHHCC patients who underwent repeated RFA combined with chemoembolization between July 2008 and June 2011. A new management strategy for SHHCC was described. The mean tumor size of the patients was 11.5±1.0 cm. No technical failure occurred, no patient succumbed to the disease during this treatment and the median survival of all 9 patients was 34 months. Treatment of the 9 tumors required a mean of 8.2±1.5 sessions. The mean of RF applications per session was 5.3±0.9 and the mean time of one session was 165±30 min, including a mean time of RF application of 113±19 min. The SHHCCs were found to be completely ablated. The mean number of RFA for primary complete ablation was 7.0±0.9 sessions, and the mean time for primary complete ablation was 5.3±1.1 months. The overall survival rate was 100%. There were 4 actual 2-year survivors. Our data reveal that tactically and strategically performed RFA should be recommended to SHHCC patients who are not suitable or do not agree to surgery, with satisfactory efficacy and safety.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Solitary huge hepatocellular carcinomas 10 cm or larger may be completely ablated by repeated radiofrequency ablation combined with chemoembolization: Initial experience with 9 patients

This article is mentioned in:

Abstract

Related Articles