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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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March 2012 Volume 5 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Increased FGFR1 copy number in lung squamous cell carcinomas

  • Authors:
    • Hidefumi Sasaki
    • Masayuki Shitara
    • Keisuke Yokota
    • Yu Hikosaka
    • Satoru Moriyama
    • Motoki Yano
    • Yoshitaka Fujii

  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan
  • Pages: 725-728
    |
    Published online on: December 15, 2011
       https://doi.org/10.3892/mmr.2011.715
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Abstract

The basic fibroblast growth factor (bFGF), via activation of its receptor, FGFR1, has been postulated to be an important inducer of host stromal response and angiogenesis. More recently, FGFR1 amplifications were investigated using large-scale single nucleotide polymorphism arrays in lung cancer. We hypothesized that FGFR1 overexpression may be correlated with the clinicopathological features of lung cancers. The increased copy number of the FGFR1 gene was analyzed by real-time polymerase chain reaction amplifications in 100 surgically treated non-small cell lung cancer cases from Nagoya City University Hospital. Sixty-five squamous cell carcinoma cases were included. An increased FGFR1 gene copy number was found in 32 (32%) lung cancer patients. The increased FGFR1 copy number status significantly correlated with gender (females 13.8% vs. males 39.4%, p=0.0173), smoking status (never smoker 4.2% vs. smoker 40.8%, p=0.0004) and pathological subtypes (squamous cell carcinoma 41.5% vs. non-squamous cell carcinoma 14.3%, p=0.0066). However, within the squamous cell carcinomas the FGFR1 copy number status did not significantly correlate with gender, smoking status, pathological stages and differentiation status of the lung cancers. Thus, the FGFR1 copy number is common within squamous cell carcinoma.

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Copy and paste a formatted citation
Spandidos Publications style
Sasaki H, Shitara M, Yokota K, Hikosaka Y, Moriyama S, Yano M and Fujii Y: Increased FGFR1 copy number in lung squamous cell carcinomas. Mol Med Rep 5: 725-728, 2012.
APA
Sasaki, H., Shitara, M., Yokota, K., Hikosaka, Y., Moriyama, S., Yano, M., & Fujii, Y. (2012). Increased FGFR1 copy number in lung squamous cell carcinomas. Molecular Medicine Reports, 5, 725-728. https://doi.org/10.3892/mmr.2011.715
MLA
Sasaki, H., Shitara, M., Yokota, K., Hikosaka, Y., Moriyama, S., Yano, M., Fujii, Y."Increased FGFR1 copy number in lung squamous cell carcinomas". Molecular Medicine Reports 5.3 (2012): 725-728.
Chicago
Sasaki, H., Shitara, M., Yokota, K., Hikosaka, Y., Moriyama, S., Yano, M., Fujii, Y."Increased FGFR1 copy number in lung squamous cell carcinomas". Molecular Medicine Reports 5, no. 3 (2012): 725-728. https://doi.org/10.3892/mmr.2011.715
Copy and paste a formatted citation
x
Spandidos Publications style
Sasaki H, Shitara M, Yokota K, Hikosaka Y, Moriyama S, Yano M and Fujii Y: Increased FGFR1 copy number in lung squamous cell carcinomas. Mol Med Rep 5: 725-728, 2012.
APA
Sasaki, H., Shitara, M., Yokota, K., Hikosaka, Y., Moriyama, S., Yano, M., & Fujii, Y. (2012). Increased FGFR1 copy number in lung squamous cell carcinomas. Molecular Medicine Reports, 5, 725-728. https://doi.org/10.3892/mmr.2011.715
MLA
Sasaki, H., Shitara, M., Yokota, K., Hikosaka, Y., Moriyama, S., Yano, M., Fujii, Y."Increased FGFR1 copy number in lung squamous cell carcinomas". Molecular Medicine Reports 5.3 (2012): 725-728.
Chicago
Sasaki, H., Shitara, M., Yokota, K., Hikosaka, Y., Moriyama, S., Yano, M., Fujii, Y."Increased FGFR1 copy number in lung squamous cell carcinomas". Molecular Medicine Reports 5, no. 3 (2012): 725-728. https://doi.org/10.3892/mmr.2011.715
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