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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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March 2012 Volume 5 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

E-cadherin and 5-HT alterations in the heart of rats having undergone atropine-induced toxicity

  • Authors:
    • Quan-Yong Huang
    • Xue-Fang Li
    • Shui-Ping Liu

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, School of Basic Medical Sciences, Dali University, Dali, Yunnan 671000, P.R. China, School of Basic Medical Sciences, Dali University, Dali, Yunnan 671000, P.R. China, Department of Forensic Pathology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, P.R. China
  • Pages: 700-704
    |
    Published online on: December 20, 2011
       https://doi.org/10.3892/mmr.2011.727
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Abstract

Atropine-induced heart damage is associated with changes in the expression of various enzymes and proteins. The purpose of this study was to investigate atropine-induced alterations in cardiac E-cadherin and 5-hydroxytryptamine (5-HT) after atropine administration. Male Wistar rats were randomly divided into two groups: a control group and an atropine group. The atropine group intraperitoneally received atropine at a single dose of 15 mg/kg for 7 days; the controls received the same amount of saline via the same route. On Day 8, the rats were anesthetized, and a thoracotomy was performed in all animals. Immunohistochemical analysis was performed to evaluate protein expression of E-cadherin and 5-HT. Sections were analyzed by digital image analysis. Cardiac protein expression of E-cadherin and 5-HT was altered after atropine‑induced toxicity in the rat. The expression levels of E-cadherin and 5-HT were significantly decreased after atropine treatment, supported by IOD analysis, when compared with the control (P<0.05). The current findings indicate that such changes would be reflected in abnormal cardiac function, and these proteins may be useful for revealing the mechanisms underlying atropine-induced toxicity and may also provide various clues for further research.

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Copy and paste a formatted citation
Spandidos Publications style
Huang Q, Li X and Liu S: E-cadherin and 5-HT alterations in the heart of rats having undergone atropine-induced toxicity. Mol Med Rep 5: 700-704, 2012.
APA
Huang, Q., Li, X., & Liu, S. (2012). E-cadherin and 5-HT alterations in the heart of rats having undergone atropine-induced toxicity. Molecular Medicine Reports, 5, 700-704. https://doi.org/10.3892/mmr.2011.727
MLA
Huang, Q., Li, X., Liu, S."E-cadherin and 5-HT alterations in the heart of rats having undergone atropine-induced toxicity". Molecular Medicine Reports 5.3 (2012): 700-704.
Chicago
Huang, Q., Li, X., Liu, S."E-cadherin and 5-HT alterations in the heart of rats having undergone atropine-induced toxicity". Molecular Medicine Reports 5, no. 3 (2012): 700-704. https://doi.org/10.3892/mmr.2011.727
Copy and paste a formatted citation
x
Spandidos Publications style
Huang Q, Li X and Liu S: E-cadherin and 5-HT alterations in the heart of rats having undergone atropine-induced toxicity. Mol Med Rep 5: 700-704, 2012.
APA
Huang, Q., Li, X., & Liu, S. (2012). E-cadherin and 5-HT alterations in the heart of rats having undergone atropine-induced toxicity. Molecular Medicine Reports, 5, 700-704. https://doi.org/10.3892/mmr.2011.727
MLA
Huang, Q., Li, X., Liu, S."E-cadherin and 5-HT alterations in the heart of rats having undergone atropine-induced toxicity". Molecular Medicine Reports 5.3 (2012): 700-704.
Chicago
Huang, Q., Li, X., Liu, S."E-cadherin and 5-HT alterations in the heart of rats having undergone atropine-induced toxicity". Molecular Medicine Reports 5, no. 3 (2012): 700-704. https://doi.org/10.3892/mmr.2011.727
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