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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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March 2012 Volume 5 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

α-enolase and caveolin alterations in the heart of rats having undergone gentamicin-induced toxicity

  • Authors:
    • Quan-Yong Huang
    • Xue-Fang Li
    • Shui-Ping Liu

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, School of Basic Medical Sciences, Dali University, Dali, Yunnan 671000, P.R. China, School of Basic Medical Sciences, Dali University, Dali, Yunnan 671000, P.R. China, Department of Forensic Pathology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, P.R. China
  • Pages: 710-714
    |
    Published online on: December 20, 2011
       https://doi.org/10.3892/mmr.2011.728
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Abstract

Gentamicin (GM)-induced heart damage is associated with alterations in expression levels of various enzymes and proteins. The aim of the present study was to investigate GM-induced alterations in cardiac α-enolase and caveolin after GM administration. Male Wistar rats were randomly divided into two groups: a control group and a GM group. The GM group intraperitoneally received GM at a single dose of 7 mg/kg for 8 days, while the controls were given the same amount of saline via the same route. On Day 9, the rats were anesthetized and a thoracotomy was performed in all animals. Immunohistochemical analysis was performed to evaluate protein expression of α-enolase and caveolin. Sections were analyzed by digital image analysis. Our results revealed that cardiac protein expression of α-enolase and caveolin was altered after GM-induced toxicity in the rat. The expression of α-enolase and caveolin was significantly increased after GM-induced toxicity, as determined by integrated optical density analysis, when compared with the control (P<0.05). The current findings indicate that such changes in protein expression may be reflected in abnormal cardiac function, and the proteins identified in this study may be useful for elucidating the mechanisms underlying GM-induced toxicity and may also provide various clues for further investigations.

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Copy and paste a formatted citation
Spandidos Publications style
Huang Q, Li X and Liu S: α-enolase and caveolin alterations in the heart of rats having undergone gentamicin-induced toxicity. Mol Med Rep 5: 710-714, 2012.
APA
Huang, Q., Li, X., & Liu, S. (2012). α-enolase and caveolin alterations in the heart of rats having undergone gentamicin-induced toxicity. Molecular Medicine Reports, 5, 710-714. https://doi.org/10.3892/mmr.2011.728
MLA
Huang, Q., Li, X., Liu, S."α-enolase and caveolin alterations in the heart of rats having undergone gentamicin-induced toxicity". Molecular Medicine Reports 5.3 (2012): 710-714.
Chicago
Huang, Q., Li, X., Liu, S."α-enolase and caveolin alterations in the heart of rats having undergone gentamicin-induced toxicity". Molecular Medicine Reports 5, no. 3 (2012): 710-714. https://doi.org/10.3892/mmr.2011.728
Copy and paste a formatted citation
x
Spandidos Publications style
Huang Q, Li X and Liu S: α-enolase and caveolin alterations in the heart of rats having undergone gentamicin-induced toxicity. Mol Med Rep 5: 710-714, 2012.
APA
Huang, Q., Li, X., & Liu, S. (2012). α-enolase and caveolin alterations in the heart of rats having undergone gentamicin-induced toxicity. Molecular Medicine Reports, 5, 710-714. https://doi.org/10.3892/mmr.2011.728
MLA
Huang, Q., Li, X., Liu, S."α-enolase and caveolin alterations in the heart of rats having undergone gentamicin-induced toxicity". Molecular Medicine Reports 5.3 (2012): 710-714.
Chicago
Huang, Q., Li, X., Liu, S."α-enolase and caveolin alterations in the heart of rats having undergone gentamicin-induced toxicity". Molecular Medicine Reports 5, no. 3 (2012): 710-714. https://doi.org/10.3892/mmr.2011.728
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