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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
March 2012 Volume 5 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 2012 Volume 5 Issue 3

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Article

Synergistic antitumor interactions between gemcitabine and clofarabine in human pancreatic cancer cell lines

  • Authors:
    • Yingjie Guo
    • Xuelian Xu
    • Wenxiu Qi
    • Chengzhi Xie
    • Guan Wang
    • Aijun Zhang
    • Yubin Ge

  • View Affiliations / Copyright

    Affiliations: The State Engineering Laboratory of AIDS Vaccine, College of Life Science, Jilin University, Changchun, P.R. China, Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, Jilin University, Changchun, P.R. China, Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, USA
  • Pages: 734-738
    |
    Published online on: December 23, 2011
       https://doi.org/10.3892/mmr.2011.738
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Abstract

Pancreatic cancer is a highly malignant disease, with a 5-year survival rate of less than 4%. Thus, new therapies for this deadly disease are urgently required. In this study, we sought to investigate whether combination treatments with gemcitabine and clofarabine result in synergistic cytotoxic effects against human pancreatic cancer cells. The type and extent of cytotoxic interactions between gemcitabine and clofarabine in three human pancreatic cancer cell lines were determined by MTT assays and standard isobologram analysis. The effects of the two agents on cell cycle distribution and apoptosis were determined by flow cytometry. Clofarabine significantly and synergistically enhanced gemcitabine cytotoxicities in all of the cell lines tested. This was accompanied by a nearly complete S phase arrest and synergistic induction of apoptosis (cooperativity index = 0.67). Combined treatment of gemcitabine and clofarabine resulted in synergistic cytotoxicities in vitro. Our results strongly suggest potential clinical benefits for using this drug combination to treat pancreatic cancer patients.

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Copy and paste a formatted citation
Spandidos Publications style
Guo Y, Xu X, Qi W, Xie C, Wang G, Zhang A and Ge Y: Synergistic antitumor interactions between gemcitabine and clofarabine in human pancreatic cancer cell lines. Mol Med Rep 5: 734-738, 2012.
APA
Guo, Y., Xu, X., Qi, W., Xie, C., Wang, G., Zhang, A., & Ge, Y. (2012). Synergistic antitumor interactions between gemcitabine and clofarabine in human pancreatic cancer cell lines. Molecular Medicine Reports, 5, 734-738. https://doi.org/10.3892/mmr.2011.738
MLA
Guo, Y., Xu, X., Qi, W., Xie, C., Wang, G., Zhang, A., Ge, Y."Synergistic antitumor interactions between gemcitabine and clofarabine in human pancreatic cancer cell lines". Molecular Medicine Reports 5.3 (2012): 734-738.
Chicago
Guo, Y., Xu, X., Qi, W., Xie, C., Wang, G., Zhang, A., Ge, Y."Synergistic antitumor interactions between gemcitabine and clofarabine in human pancreatic cancer cell lines". Molecular Medicine Reports 5, no. 3 (2012): 734-738. https://doi.org/10.3892/mmr.2011.738
Copy and paste a formatted citation
x
Spandidos Publications style
Guo Y, Xu X, Qi W, Xie C, Wang G, Zhang A and Ge Y: Synergistic antitumor interactions between gemcitabine and clofarabine in human pancreatic cancer cell lines. Mol Med Rep 5: 734-738, 2012.
APA
Guo, Y., Xu, X., Qi, W., Xie, C., Wang, G., Zhang, A., & Ge, Y. (2012). Synergistic antitumor interactions between gemcitabine and clofarabine in human pancreatic cancer cell lines. Molecular Medicine Reports, 5, 734-738. https://doi.org/10.3892/mmr.2011.738
MLA
Guo, Y., Xu, X., Qi, W., Xie, C., Wang, G., Zhang, A., Ge, Y."Synergistic antitumor interactions between gemcitabine and clofarabine in human pancreatic cancer cell lines". Molecular Medicine Reports 5.3 (2012): 734-738.
Chicago
Guo, Y., Xu, X., Qi, W., Xie, C., Wang, G., Zhang, A., Ge, Y."Synergistic antitumor interactions between gemcitabine and clofarabine in human pancreatic cancer cell lines". Molecular Medicine Reports 5, no. 3 (2012): 734-738. https://doi.org/10.3892/mmr.2011.738
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