Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
February 2013 Volume 7 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February 2013 Volume 7 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

GSTM1 polymorphism modifies the effect of smoking on calcaneal quantitative ultrasound in young men

  • Authors:
    • Tao Liu
    • Xuechuan Sun
    • Xiao Zhuang
    • Jingqun Liang
  • View Affiliations / Copyright

    Affiliations: West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan, P.R. China, Physics Department, Medical College of Shantou University, Shantou, Guangdong, P.R. China, Scientific Research Department, PLA Institute of Physical Education, Guangzhou, Guangdong, P.R. China
  • Pages: 509-512
    |
    Published online on: November 21, 2012
       https://doi.org/10.3892/mmr.2012.1192
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Evidence suggests that smoking adversely affects bones. Glutathione S-transferases (GSTs) are important in the detoxification of tobacco smoke compounds. This study investigated the influence of GSTM1 and GSTT1 genetic polymorphisms on the effects on bone induced by tobacco smoking in young men. In total, 231 Chinese men aged 20-39 years were assessed by a cross-sectional study. Calcaneal quantitative ultrasound (QUS) was measured. Smoking information was obtained using a questionnaire. Genotypes were determined for null alleles of GSTM1 and GSTT1. Smoking was inversely associated with speed of sound (SOS) and bone quality index (BQI) among subjects with GSTM1 null genotype (β = -0.28, 95% CI, -34.01 to -8.65 and β = -0.30, 95% CI, -16.41 to -4.49, respectively), but not among those with the allele present (β = -0.02, 95% CI, -15.01 to 12.59 and β = -0.09, 95% CI, -8.75 to 3.02, respectively). P for interaction = 0.04 for SOS and 0.08 for BQI. No interaction was found between the GSTT1 polymorphism and smoking. The results showed that GSTM1 deficiency may increase the adverse effect of smoking on calcaneal QUS in young men, suggesting an interaction between metabolic genes and tobacco smoke in bone detoxification.
View Figures
View References

1 

Valimaki MJ, Karkkainen M, Lamberg-Allardt C, et al: Exercise, smoking, and calcium intake during adolescence and early adulthood as determinants of peak bone mass. Br Med J. 309:230–235. 1994. View Article : Google Scholar : PubMed/NCBI

2 

Ortego-Centeno N, Munoz-Torres M, Jodar E, Hernandez-Quero J, Jurado-Duce A and Torres-Puchol JH: Effect of tobacco consumption on bone mineral density in healthy young males. Calcif Tissue Int. 60:496–500. 1997. View Article : Google Scholar : PubMed/NCBI

3 

Kelly PJ, Morrison NA, Sambrook PN, Nguyen TV and Eisman JA: Genetic influences on bone turnover, bone density and fracture. Eur J Endocrinol. 133:265–271. 1995. View Article : Google Scholar : PubMed/NCBI

4 

Lorentzon M, Mellström D, Haug E and Ohlsson C: Smoking is associated with lower bone mineral density and reduced cortical thickness in young men. J Clin Endocrinol Metab. 92:497–503. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Medraœ M, Jankowska EA and Rogucka E: The effect of smoking tobacco and drinking of alcohol and coffee on bone mineral density of healthy men 40 years of age. Pol Arch Med Wewn. 103:187–193. 2000.PubMed/NCBI

6 

Wüst RCI, Winwood K, Wilks DC, Morse CI, Degens H and Rittweger J: Effects of smoking on tibial and radial bone mass and strength may diminish with age. J Clin Endocrinol Metab. 95:2763–2771. 2010.PubMed/NCBI

7 

Sheehan D, Meade G, Foley VM and Dowd CA: Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily. Biochem J. 360:1–16. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Pemble S, Schroeder KR, Spencer SR, et al: Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism. Biochem J. 300:271–276. 1994.PubMed/NCBI

9 

Seidegard J, Vorachek WR, Pero RW and Pearson WR: Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion. Proc Natl Acad Sci USA. 85:7293–7297. 1988. View Article : Google Scholar : PubMed/NCBI

10 

Dialyna IA, Miyakis S, Georgatou N and Spandidos DA: Genetic polymorphisms of CYP1A1, GSTM1 and GSTT1 genes and lung cancer risk. Oncol Rep. 10:1829–1835. 2003.

11 

Setiawan VW, Zhang ZF, Yu GP, et al: GSTT1 and GSTM1 null genotypes and the risk of gastric cancer: a case-control study in a Chinese population. Cancer Epidemiol Biomarkers Prev. 9:73–80. 2000.PubMed/NCBI

12 

Nelson HH, Wiencke JK, Christiani DC, et al: Ethnic differences in the prevalence of the homozygous deleted genotype of glutathione S-transferase θ. Carcinogenesis (Lond). 16:1243–1245. 1995.

13 

Baecke JA, Burema J and Frijters JE: A short questionnaire for the measurement of habitual physical activity in epidemiological studies. Am J Clin Nutr. 36:936–942. 1982.PubMed/NCBI

14 

Abdel-Rahman SZ, el-Zein RA, Anwar WA and Au WW: A multiplex PCR procedure for polymorphic analysis of GSTM1 and GSTT1 genes in population studies. Cancer Lett. 107:229–233. 1996. View Article : Google Scholar : PubMed/NCBI

15 

Shen J, Lin G, Yuan W, Tan J, Bolt HM and Thier R: Glutathione transferase T1 and M1 genotype polymorphism in the normal population of Shanghai. Arch Toxicol. 72:456–458. 1998. View Article : Google Scholar : PubMed/NCBI

16 

Landi S: Mammalian class theta GST and differential susceptibility to carcinogens: a review. Mutat Res. 463:247–283. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Ruano-Ravina A, Figueiras A, Loidi L and Barros-Dios JM: GSTM1 and GSTT1 polymorphisms, tobacco and risk of lung cancer: a case-control study from Galicia, Spain. Anticancer Res. 23:4333–4337. 2003.PubMed/NCBI

18 

Lee KM, Kang D, Lee SJ, et al: Interactive effect of genetic polymorphism of glutathione S-transferase M1 and smoking on squamous cell lung cancer risk in Korea. Oncol Rep. 16:1035–1039. 2006.PubMed/NCBI

19 

Fang MA, Frost PJ, Iida-Klein A and Hahn TJ: Effects of nicotine on cellular function in UMR 106-01 osteoblast-like cells. Bone. 12:283–286. 1991. View Article : Google Scholar : PubMed/NCBI

20 

Ramp WK, Lenz LG and Galvin RJS: Nicotine inhibits collagen synthesis and alkaline phosphatase activity, but stimulates DNA synthesis in osteoblast-like cells. Proc Soc Exp Biol Med. 197:36–43. 1991. View Article : Google Scholar : PubMed/NCBI

21 

Fung YK, Iwaniec U, Cullen DM, Akhter MP, Haven MC and Timmins P: Long-term effects of nicotine on bone and calciotropic hormones in adult female rats. Pharmacol Toxicol. 85:181–187. 1999. View Article : Google Scholar : PubMed/NCBI

22 

Hayes JD and McLellan LI: Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress. Free Radic Res. 31:273–300. 1999. View Article : Google Scholar : PubMed/NCBI

23 

Basu S, Michaelsson K, Olofsson H, Johansson S and Melhus H: Association between oxidative stress and bone mineral density. Biochem Biophys Res Commun. 288:275–279. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Koh JM, Lee YS, Kim YS, et al: Homocysteine enhances bone resorption by stimulation of osteoclast formation and activity through increased intracellular ROS generation. J Bone Miner Res. 21:1003–1011. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Almeida M, Han L, Martin-Millan M, O’Brien CA and Manolagas SC: Oxidative stress antagonizes wnt signaling in osteoblast precursors by diverting β-catenin from T cell factor- to forkhead box O-mediated transcription. J Biol Chem. 282:27298–27305. 2007.

26 

Almeida M, Han L, Martin-Millan M, et al: Skeletal involution by age-associated oxidative stress and its acceleration by lossof sex steroids. J Biol Chem. 282:27285–27297. 2007. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu T, Sun X, Zhuang X and Liang J: GSTM1 polymorphism modifies the effect of smoking on calcaneal quantitative ultrasound in young men. Mol Med Rep 7: 509-512, 2013.
APA
Liu, T., Sun, X., Zhuang, X., & Liang, J. (2013). GSTM1 polymorphism modifies the effect of smoking on calcaneal quantitative ultrasound in young men. Molecular Medicine Reports, 7, 509-512. https://doi.org/10.3892/mmr.2012.1192
MLA
Liu, T., Sun, X., Zhuang, X., Liang, J."GSTM1 polymorphism modifies the effect of smoking on calcaneal quantitative ultrasound in young men". Molecular Medicine Reports 7.2 (2013): 509-512.
Chicago
Liu, T., Sun, X., Zhuang, X., Liang, J."GSTM1 polymorphism modifies the effect of smoking on calcaneal quantitative ultrasound in young men". Molecular Medicine Reports 7, no. 2 (2013): 509-512. https://doi.org/10.3892/mmr.2012.1192
Copy and paste a formatted citation
x
Spandidos Publications style
Liu T, Sun X, Zhuang X and Liang J: GSTM1 polymorphism modifies the effect of smoking on calcaneal quantitative ultrasound in young men. Mol Med Rep 7: 509-512, 2013.
APA
Liu, T., Sun, X., Zhuang, X., & Liang, J. (2013). GSTM1 polymorphism modifies the effect of smoking on calcaneal quantitative ultrasound in young men. Molecular Medicine Reports, 7, 509-512. https://doi.org/10.3892/mmr.2012.1192
MLA
Liu, T., Sun, X., Zhuang, X., Liang, J."GSTM1 polymorphism modifies the effect of smoking on calcaneal quantitative ultrasound in young men". Molecular Medicine Reports 7.2 (2013): 509-512.
Chicago
Liu, T., Sun, X., Zhuang, X., Liang, J."GSTM1 polymorphism modifies the effect of smoking on calcaneal quantitative ultrasound in young men". Molecular Medicine Reports 7, no. 2 (2013): 509-512. https://doi.org/10.3892/mmr.2012.1192
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team