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Article

Analysis of critical molecules and signaling pathways in osteoarthritis and rheumatoid arthritis

  • Authors:
    • Feng Xue
    • Changqing Zhang
    • Zhimin He
    • Liang Ding
    • Haijun Xiao
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedics, Fengxian Central Hospital, Shanghai 201400, P.R. China, Department of Orthopaedics, The Six People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, P.R. China
  • Pages: 603-607
    |
    Published online on: December 4, 2012
       https://doi.org/10.3892/mmr.2012.1224
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Abstract

Osteoarthritis (OA) and rheumatoid arthritis (RA) are the most prevalent forms of arthritis in the elderly. This study aimed to explore the molecular mechanisms of these diseases and identify underlying therapeutic targets. Using GSE1919 microarray data sets downloaded from the Gene Expression Omnibus database, we screened differentially expressed genes (DEGs) in OA and RA cells. The underlying molecular mechanisms of these crucial genes were investigated by Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis. Small molecule expression and SNP analysis were also conducted by searching CMap and dbSNP databases. More than 320 genes changed in the arthritic cells and there were only 196 DEGs between OA and RA. OA and RA activated the classic mitogen-activated protein kinase signaling pathway, insulin signaling pathway, antigen processing and presentation and intestinal immune network for IgA production. Graft-versus-host disease and autoimmune thyroid disease-related pathways were also activated in OA and RA. Parthenolide and alsterpaullone may be treatments for OA and RA and insulin-like growth factor 1, collagen α2(I) chain and special AT-rich sequence-binding protein 2 may be critical SNP molecules in arthritis. Our findings shed new light on the common molecular mechanisms of OA and RA and may provide theoretical support for further clinical therapeutic studies.
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Copy and paste a formatted citation
Spandidos Publications style
Xue F, Zhang C, He Z, Ding L and Xiao H: Analysis of critical molecules and signaling pathways in osteoarthritis and rheumatoid arthritis. Mol Med Rep 7: 603-607, 2013.
APA
Xue, F., Zhang, C., He, Z., Ding, L., & Xiao, H. (2013). Analysis of critical molecules and signaling pathways in osteoarthritis and rheumatoid arthritis. Molecular Medicine Reports, 7, 603-607. https://doi.org/10.3892/mmr.2012.1224
MLA
Xue, F., Zhang, C., He, Z., Ding, L., Xiao, H."Analysis of critical molecules and signaling pathways in osteoarthritis and rheumatoid arthritis". Molecular Medicine Reports 7.2 (2013): 603-607.
Chicago
Xue, F., Zhang, C., He, Z., Ding, L., Xiao, H."Analysis of critical molecules and signaling pathways in osteoarthritis and rheumatoid arthritis". Molecular Medicine Reports 7, no. 2 (2013): 603-607. https://doi.org/10.3892/mmr.2012.1224
Copy and paste a formatted citation
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Spandidos Publications style
Xue F, Zhang C, He Z, Ding L and Xiao H: Analysis of critical molecules and signaling pathways in osteoarthritis and rheumatoid arthritis. Mol Med Rep 7: 603-607, 2013.
APA
Xue, F., Zhang, C., He, Z., Ding, L., & Xiao, H. (2013). Analysis of critical molecules and signaling pathways in osteoarthritis and rheumatoid arthritis. Molecular Medicine Reports, 7, 603-607. https://doi.org/10.3892/mmr.2012.1224
MLA
Xue, F., Zhang, C., He, Z., Ding, L., Xiao, H."Analysis of critical molecules and signaling pathways in osteoarthritis and rheumatoid arthritis". Molecular Medicine Reports 7.2 (2013): 603-607.
Chicago
Xue, F., Zhang, C., He, Z., Ding, L., Xiao, H."Analysis of critical molecules and signaling pathways in osteoarthritis and rheumatoid arthritis". Molecular Medicine Reports 7, no. 2 (2013): 603-607. https://doi.org/10.3892/mmr.2012.1224
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