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Article

Berberine‑attenuated monocyte adhesion to endothelial cells induced by oxidized low‑density lipoprotein via inhibition of adhesion molecule expression

  • Authors:
    • Zhouqing Huang
    • Xueli Cai
    • Sheng Li
    • Hao Zhou
    • Maoping  Chu
    • Peiren Shan
    • Weijian Huang
  • View Affiliations / Copyright

    Affiliations: Cardiac Center, The First Affiliated Hospital of Wenzhou Medical College, Zhejiang 325000, P.R. China
  • Pages: 461-465
    |
    Published online on: December 14, 2012
       https://doi.org/10.3892/mmr.2012.1236
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Abstract

Recruitment of monocytes to endothelial cells is important during early stages of atherosclerosis development. This process is predominantly mediated by cellular adhesion molecules, including vascular cell adhesion molecule‑1 (VCAM‑1) and intercellular adhesion molecule‑1 (ICAM‑1), which are expressed by activated endothelial cells in response to a number of inflammatory stimuli, including oxidized low‑density lipoprotein (oxLDL). Previous studies have demonstrated that berberine, a natural extract from Rhizoma coptidis, prevents oxLDL‑induced endothelial cellular apoptosis. However, its effect on the adhesion of monocytes to endothelial cells and the mechanism associated with this process remains unclear. In the present study, berberine was revealed to markedly reduce oxLDL‑induced monocyte adhesion to human umbilical vein endothelial cells. In addition, the inhibitory mechanism of berberine was associated with suppression of adhesion molecule expression, including VCAM‑1 and ICAM‑1. Results indicate that berberine plays a protective role in the early stages of atherosclerosis.
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Copy and paste a formatted citation
Spandidos Publications style
Huang Z, Cai X, Li S, Zhou H, Chu M, Shan P and Huang W: Berberine‑attenuated monocyte adhesion to endothelial cells induced by oxidized low‑density lipoprotein via inhibition of adhesion molecule expression. Mol Med Rep 7: 461-465, 2013.
APA
Huang, Z., Cai, X., Li, S., Zhou, H., Chu, M., Shan, P., & Huang, W. (2013). Berberine‑attenuated monocyte adhesion to endothelial cells induced by oxidized low‑density lipoprotein via inhibition of adhesion molecule expression. Molecular Medicine Reports, 7, 461-465. https://doi.org/10.3892/mmr.2012.1236
MLA
Huang, Z., Cai, X., Li, S., Zhou, H., Chu, M., Shan, P., Huang, W."Berberine‑attenuated monocyte adhesion to endothelial cells induced by oxidized low‑density lipoprotein via inhibition of adhesion molecule expression". Molecular Medicine Reports 7.2 (2013): 461-465.
Chicago
Huang, Z., Cai, X., Li, S., Zhou, H., Chu, M., Shan, P., Huang, W."Berberine‑attenuated monocyte adhesion to endothelial cells induced by oxidized low‑density lipoprotein via inhibition of adhesion molecule expression". Molecular Medicine Reports 7, no. 2 (2013): 461-465. https://doi.org/10.3892/mmr.2012.1236
Copy and paste a formatted citation
x
Spandidos Publications style
Huang Z, Cai X, Li S, Zhou H, Chu M, Shan P and Huang W: Berberine‑attenuated monocyte adhesion to endothelial cells induced by oxidized low‑density lipoprotein via inhibition of adhesion molecule expression. Mol Med Rep 7: 461-465, 2013.
APA
Huang, Z., Cai, X., Li, S., Zhou, H., Chu, M., Shan, P., & Huang, W. (2013). Berberine‑attenuated monocyte adhesion to endothelial cells induced by oxidized low‑density lipoprotein via inhibition of adhesion molecule expression. Molecular Medicine Reports, 7, 461-465. https://doi.org/10.3892/mmr.2012.1236
MLA
Huang, Z., Cai, X., Li, S., Zhou, H., Chu, M., Shan, P., Huang, W."Berberine‑attenuated monocyte adhesion to endothelial cells induced by oxidized low‑density lipoprotein via inhibition of adhesion molecule expression". Molecular Medicine Reports 7.2 (2013): 461-465.
Chicago
Huang, Z., Cai, X., Li, S., Zhou, H., Chu, M., Shan, P., Huang, W."Berberine‑attenuated monocyte adhesion to endothelial cells induced by oxidized low‑density lipoprotein via inhibition of adhesion molecule expression". Molecular Medicine Reports 7, no. 2 (2013): 461-465. https://doi.org/10.3892/mmr.2012.1236
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