1
|
Freemont AJ: The cellular pathobiology of
the degenerate intervertebral disc and discogenic back pain.
Rheumatology (Oxford). 48:5–10. 2009. View Article : Google Scholar : PubMed/NCBI
|
2
|
Smith LJ, Nerurkar NL, Choi KS, et al:
Degeneration and regeneration of the intervertebral disc: lessons
from development. Dis Model Mech. 4:31–41. 2011. View Article : Google Scholar : PubMed/NCBI
|
3
|
Le Maitre CL, Freemont AJ and Hoyland JA:
The role of interleukin-1 in the pathogenesis of human
intervertebral disc degeneration. Arthritis Res Ther. 7:R732–R745.
2005.
|
4
|
Le Maitre CL, Freemont AJ and Hoyland JA:
A preliminary in vitro study into the use of IL-1Ra gene therapy
for the inhibition of intervertebral disc degeneration. Int J Exp
Pathol. 87:17–28. 2006.PubMed/NCBI
|
5
|
Smith LJ, Chiaro JA, Nerurkar NL, et al:
Nucleus pulposus cells synthesize a functional extracellular matrix
and respond to inflammatory cytokine challenge following long-term
agarose culture. Eur Cell Mater. 22:291–301. 2011.
|
6
|
Studer RK, Vo N, Sowa G, et al: Human
nucleus pulposus cells react to IL-6: independent actions and
amplification of response to IL-1 and TNF-α. Spine (Phila Pa 1976).
36:593–599. 2011.PubMed/NCBI
|
7
|
Zhang R, Ruan D and Zhang C: Effects of
TGF-beta1 and IGF-1 on proliferation of human nucleus pulposus
cells in medium with different serum concentrations. J Orthop Surg
Res. 1:92006. View Article : Google Scholar : PubMed/NCBI
|
8
|
Pratsinis H, Constantinou V, Pavlakis K,
et al: Exogenous and autocrine growth factors stimulate human
intervertebral disc cell proliferation via the ERK and Akt
pathways. J Orthop Res. 30:958–964. 2012. View Article : Google Scholar : PubMed/NCBI
|
9
|
Okuda S, Myoui A, Ariga K, et al:
Mechanisms of age-related decline in insulin-like growth factor-I
dependent proteoglycan synthesis in rat intervertebral disc cells.
Spine (Phila Pa 1976). 26:2421–2426. 2001. View Article : Google Scholar : PubMed/NCBI
|
10
|
Osada R, Ohshima H, Ishihara H, et al:
Autocrine/paracrine mechanism of insulin-like growth factor-1
secretion, and the effect of insulin-like growth factor-1 on
proteoglycan synthesis in bovine intervertebral discs. J Orthop
Res. 14:690–699. 1996. View Article : Google Scholar : PubMed/NCBI
|
11
|
Erwin WM, Islam D, Inman RD, et al:
Notochordal cells protect nucleus pulposus cells from degradation
and apoptosis: implications for the mechanisms of intervertebral
disc degeneration. Arthritis Res Ther. 13:R2152011. View Article : Google Scholar : PubMed/NCBI
|
12
|
Millward-Sadler SJ, Costello PW, Freemont
AJ and Hoyland JA: Regulation of catabolic gene expression in
normal and degenerate human intervertebral disc cells: implications
for the pathogenesis of intervertebral disc degeneration. Arthritis
Res Ther. 11:R652009. View
Article : Google Scholar : PubMed/NCBI
|
13
|
Park JY, Kuh SU, Park HS and Kim KS:
Comparative expression of matrix-associated genes and inflammatory
cytokines-associated genes according to disc degeneration: analysis
of living human nucleus pulposus. J Spinal Disord Tech. 24:352–357.
2011. View Article : Google Scholar
|
14
|
Studer RK, Aboka AM, Gilbertson LG, et al:
p38 MAPK inhibition in nucleus pulposus cells: a potential target
for treating intervertebral disc degeneration. Spine (Phila Pa
1976). 32:2827–2833. 2007. View Article : Google Scholar : PubMed/NCBI
|
15
|
Zhang Y, An HS, Toofanfard M, et al:
Low-dose interleukin-1 partially counteracts osteogenic
protein-1-induced proteoglycan synthesis by adult bovine
intervertebral disk cells. Am J Phys Med Rehabil. 84:322–329. 2005.
View Article : Google Scholar : PubMed/NCBI
|
16
|
Mavrogonatou E and Kletsas D: Effect of
varying osmotic conditions on the response of bovine nucleus
pulposus cells to growth factors and the activation of the ERK and
Akt pathways. J Orthop Res. 28:1276–1282. 2010. View Article : Google Scholar : PubMed/NCBI
|
17
|
Murakami H, Yoon ST, Attallah-Wasif ES, et
al: The expression of anabolic cytokines in intervertebral discs in
age-related degeneration. Spine (Phila Pa 1976). 31:1770–1774.
2006. View Article : Google Scholar : PubMed/NCBI
|
18
|
Okuda S, Myoui A, Ariga K, et al:
Mechanisms of age-related decline in insulin-like growth factor-I
dependent proteoglycan synthesis in rat intervertebral disc cells.
Spine (Phila Pa 1976). 26:2421–2426. 2001. View Article : Google Scholar : PubMed/NCBI
|
19
|
Le Maitre CL, Richardson SM, Baird P, et
al: Expression of receptors for putative anabolic growth factors in
human intervertebral disc: implications for repair and regeneration
of the disc. J Pathol. 207:445–452. 2005.PubMed/NCBI
|
20
|
Jiang F, Frederick TJ and Wood TL: IGF-I
synergizes with FGF-2 to stimulate oligodendrocyte progenitor entry
into the cell cycle. Dev Biol. 232:414–423. 2001. View Article : Google Scholar : PubMed/NCBI
|