Endothelial cell activation and proliferation in ovarian tumors: Two distinct steps as potential markers for antiangiogenic therapy response

Pirtea,Laurenţiu; Raica,Marius; Cimpean,Anca Maria

doi:10.3892/mmr.2012.812

May 2012 Volume 5 Issue 5

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May 2012 Volume 5 Issue 5

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Article

Endothelial cell activation and proliferation in ovarian tumors: Two distinct steps as potential markers for antiangiogenic therapy response

Authors:
- Laurenţiu Pirtea
- Marius Raica
- Anca Maria Cimpean
View Affiliations / Copyright

Affiliations: Department of Obstetrics and Gynecology, Angiogenesis Research Center, ‘Victor Babes’ University of Medicine and Pharmacy, Timisoara 300041, Romania, Department of Histology, Angiogenesis Research Center, ‘Victor Babes’ University of Medicine and Pharmacy, Timisoara 300041, Romania
Pages: 1181-1184
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Published online on: February 28, 2012

https://doi.org/10.3892/mmr.2012.812
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Abstract

Ovarian cancer is the second leading cause of cancer-related death in women worldwide. Since most patients are diagnosed in advanced disease stages, the starting point, early steps and molecular mechanisms of ovarian cancer angiogenesis are still incompletely characterized. Most immunohistochemical studies for assessment of microvessel density (MVD) in ovarian tumors are based on CD31, CD34 and CD105 immunostaining of tumor blood vessels. Yet, the proliferative status of tumor blood vessel endothelial cells has not as yet been used in the assessment of tumor blood vessels. The present study investigated the Ki67 proliferative index of tumor blood vessel endothelial cells highlighted with the CD34 panendothelial marker and the CD105 endothelial marker in ovarian cancers by antigen co-localization with a doublestaining immunohistochemical method. Lack of co-localization of CD105 and Ki67 in all types of ovarian tumors together with the presence of CD34+/Ki67-positive endothelial cells suggest that endothelial cell activation and proliferation are distinct steps in ovarian tumors. Differences in the proliferation index were observed in endothelial cells from blood vessels of the tumor core and those of the tumor peripheral zones. Potential specific targeting of activated and proliferating tumor blood vessels may provide clues for improving antiangiogenic therapy efficiency.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Endothelial cell activation and proliferation in ovarian tumors: Two distinct steps as potential markers for antiangiogenic therapy response

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