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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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May 2012 Volume 5 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Calcium oxalate monohydrate crystals stimulate monocyte chemoattractant protein-1 and transforming growth factor β1 expression in human renal epithelial cells

  • Authors:
    • Zhuo Liu
    • Tao Wang
    • Jun Yang
    • Shaogang Wang
    • Weimin Yang
    • Jihong Liu
    • Zhangqun Ye

  • View Affiliations / Copyright

    Affiliations: Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China
  • Pages: 1241-1244
    |
    Published online on: February 28, 2012
       https://doi.org/10.3892/mmr.2012.813
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Abstract

Crystal-cell interactions play a key role in the formation of kidney stones. Few studies have referred to the role of monocyte chemoattractant protein-1 (MCP-1) and transforming growth factor β1 (TGFβ1) in kidney stone formation. Recently, a genome-wide analysis of genes related to kidney stone formation and eliminiation in mice indicated that MCP-1 and TGFβ1 are involved in nephrolithiasis. In this study, in order to verify whether MCP-1 and TGFβ1 are involved in the process of crystal-cell interactions in vitro, we observed the effects of calcium oxalate monohydrate (COM) on MCP-1 and TGFβ1 expression in cultured HK-2 cells. HK-2 cells were treated with different concentrations of COM, and a group of untreated cells served as the control. The expression of MCP-1 and TGFβ1 was detected by western blot analysis after treatments with different COM concentrations (300, 500, 700 and 900 µg/ml) for different times (3, 6, 12 and 24 h). We found that the expression of MCP-1 was upregulated by COM treatment in a dose-dependent manner, and was increased initially at the first 6 h of treatment, then slightly decreased over time. Also, COM treatment resulted in a dose-dependent increase in TGFβ1 expression, and the expression levels peaked at 12 h. This study demonstrates that COM stimulates the expression of MCP-1 and TGFβ1 in renal epithelial cells.

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Copy and paste a formatted citation
Spandidos Publications style
Liu Z, Wang T, Yang J, Wang S, Yang W, Liu J and Ye Z: Calcium oxalate monohydrate crystals stimulate monocyte chemoattractant protein-1 and transforming growth factor β1 expression in human renal epithelial cells. Mol Med Rep 5: 1241-1244, 2012.
APA
Liu, Z., Wang, T., Yang, J., Wang, S., Yang, W., Liu, J., & Ye, Z. (2012). Calcium oxalate monohydrate crystals stimulate monocyte chemoattractant protein-1 and transforming growth factor β1 expression in human renal epithelial cells. Molecular Medicine Reports, 5, 1241-1244. https://doi.org/10.3892/mmr.2012.813
MLA
Liu, Z., Wang, T., Yang, J., Wang, S., Yang, W., Liu, J., Ye, Z."Calcium oxalate monohydrate crystals stimulate monocyte chemoattractant protein-1 and transforming growth factor β1 expression in human renal epithelial cells". Molecular Medicine Reports 5.5 (2012): 1241-1244.
Chicago
Liu, Z., Wang, T., Yang, J., Wang, S., Yang, W., Liu, J., Ye, Z."Calcium oxalate monohydrate crystals stimulate monocyte chemoattractant protein-1 and transforming growth factor β1 expression in human renal epithelial cells". Molecular Medicine Reports 5, no. 5 (2012): 1241-1244. https://doi.org/10.3892/mmr.2012.813
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Z, Wang T, Yang J, Wang S, Yang W, Liu J and Ye Z: Calcium oxalate monohydrate crystals stimulate monocyte chemoattractant protein-1 and transforming growth factor β1 expression in human renal epithelial cells. Mol Med Rep 5: 1241-1244, 2012.
APA
Liu, Z., Wang, T., Yang, J., Wang, S., Yang, W., Liu, J., & Ye, Z. (2012). Calcium oxalate monohydrate crystals stimulate monocyte chemoattractant protein-1 and transforming growth factor β1 expression in human renal epithelial cells. Molecular Medicine Reports, 5, 1241-1244. https://doi.org/10.3892/mmr.2012.813
MLA
Liu, Z., Wang, T., Yang, J., Wang, S., Yang, W., Liu, J., Ye, Z."Calcium oxalate monohydrate crystals stimulate monocyte chemoattractant protein-1 and transforming growth factor β1 expression in human renal epithelial cells". Molecular Medicine Reports 5.5 (2012): 1241-1244.
Chicago
Liu, Z., Wang, T., Yang, J., Wang, S., Yang, W., Liu, J., Ye, Z."Calcium oxalate monohydrate crystals stimulate monocyte chemoattractant protein-1 and transforming growth factor β1 expression in human renal epithelial cells". Molecular Medicine Reports 5, no. 5 (2012): 1241-1244. https://doi.org/10.3892/mmr.2012.813
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