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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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May 2012 Volume 5 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

P2X7 receptor modulation of the viability of radial glial clone L2.3 cells during hypoxic-ischemic brain injury

  • Authors:
    • Wen Zeng
    • Yu Tong
    • Hedong Li
    • Rong Luo
    • Meng Mao

  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Key Laboratory of Obstetrics and Gynecologic and Pediatric Diseases and Birth Defects, Ministry of Education, Chengdu, Sichuan 610041, P.R. China, Development and Stem Cell Institute, West China Institute of Women's and Children's Health, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China
  • Pages: 1357-1361
    |
    Published online on: February 29, 2012
       https://doi.org/10.3892/mmr.2012.816
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Abstract

The purinergic P2X7 receptor (P2X7R) can be activated by ATP and plays significant and complex roles in neuropathology. However, research is limited concerning the role of P2X7R in radial glia following hypoxia-ischemia (HI). In this study, radial glial clone L2.3 cells were cultured and subjected to oxygen-glucose deprivation (OGD) to generate an HI model in vitro. We found that HI decreased P2X7R expression in the L2.3 cells. Activation of P2X7R in L2.3 cells by 3'-O-(4-benzoylbenzoyl) adenosine 5'-triphosphate (BzATP) led to cell death in a dose- and time-dependent manner, while a P2X7R antagonist, oxidized ATP (oATP), alleviated the injury induced by BzATP or HI. We also found that P2X7R modulated the phosphorylation of glycogen synthase kinase-3β (GSK-3β). The present findings suggest that L2.3 cells express P2X7R, and this receptor may be involved in HI injury of radial glia by mediating phosphorylation of GSK-3β.

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Copy and paste a formatted citation
Spandidos Publications style
Zeng W, Tong Y, Li H, Luo R and Mao M: P2X7 receptor modulation of the viability of radial glial clone L2.3 cells during hypoxic-ischemic brain injury. Mol Med Rep 5: 1357-1361, 2012.
APA
Zeng, W., Tong, Y., Li, H., Luo, R., & Mao, M. (2012). P2X7 receptor modulation of the viability of radial glial clone L2.3 cells during hypoxic-ischemic brain injury. Molecular Medicine Reports, 5, 1357-1361. https://doi.org/10.3892/mmr.2012.816
MLA
Zeng, W., Tong, Y., Li, H., Luo, R., Mao, M."P2X7 receptor modulation of the viability of radial glial clone L2.3 cells during hypoxic-ischemic brain injury". Molecular Medicine Reports 5.5 (2012): 1357-1361.
Chicago
Zeng, W., Tong, Y., Li, H., Luo, R., Mao, M."P2X7 receptor modulation of the viability of radial glial clone L2.3 cells during hypoxic-ischemic brain injury". Molecular Medicine Reports 5, no. 5 (2012): 1357-1361. https://doi.org/10.3892/mmr.2012.816
Copy and paste a formatted citation
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Spandidos Publications style
Zeng W, Tong Y, Li H, Luo R and Mao M: P2X7 receptor modulation of the viability of radial glial clone L2.3 cells during hypoxic-ischemic brain injury. Mol Med Rep 5: 1357-1361, 2012.
APA
Zeng, W., Tong, Y., Li, H., Luo, R., & Mao, M. (2012). P2X7 receptor modulation of the viability of radial glial clone L2.3 cells during hypoxic-ischemic brain injury. Molecular Medicine Reports, 5, 1357-1361. https://doi.org/10.3892/mmr.2012.816
MLA
Zeng, W., Tong, Y., Li, H., Luo, R., Mao, M."P2X7 receptor modulation of the viability of radial glial clone L2.3 cells during hypoxic-ischemic brain injury". Molecular Medicine Reports 5.5 (2012): 1357-1361.
Chicago
Zeng, W., Tong, Y., Li, H., Luo, R., Mao, M."P2X7 receptor modulation of the viability of radial glial clone L2.3 cells during hypoxic-ischemic brain injury". Molecular Medicine Reports 5, no. 5 (2012): 1357-1361. https://doi.org/10.3892/mmr.2012.816
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