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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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May 2012 Volume 5 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

Effects of embryonic exposure to polychlorinated biphenyls on zebrafish skeletal development

  • Authors:
    • Li Ju
    • Kai Tang
    • Xi-Rong Guo
    • Yang Yang
    • Guan-Zhong Zhu
    • Yue Lou

  • View Affiliations / Copyright

    Affiliations: Department of Pediatric Orthopaedics, Nanjing Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu 210008, P.R. China, Department of Pediatric Orthopaedics, Nanjing Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu 210008, P.R. China, Institute of Pediatrics, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China
  • Pages: 1227-1231
    |
    Published online on: March 6, 2012
       https://doi.org/10.3892/mmr.2012.823
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Abstract

Polychlorinated biphenyls (PCBs) are persistent organic pollutants that affect embryonic development. The purpose of this study was to examine the effects of embryonic exposure to PCBs on early skeletal development in zebrafish (Danio rerio). Zebrafish embryos were immediately exposed to various concentrations (0, 0.125, 0.25, 0.5 and 1.0 mg/l) of PCBs (Aroclor 1254) after fertilization. Embryos were assessed at 24, 48, 72, 96 and 120 h post-fertilization (hpf) for changes in embryonic survival and malformation rates. Calcium content and vitamin D receptor (VDR), parathyroid hormone (PTH) and TRVP6 mRNA expressions were assessed at 120 hpf. The results showed that PCBs exposure decreased the survival rate of the embryos in a time-and dose-dependent manner. The embryos exposed to the higher concentrations of PCBs (0.5 and 1.0 mg/l) displayed obvious skeletal morphological deformities. At 120 hpf, the calcium content of the zebrafish was downregulated in all the PCB-treated groups. VDR, PTH and TRVP6 mRNA expressions were all affected by PCBs. By 120 hpf, the mRNA expressions of VDR, PTH and TRVP6 from the PCB-treated larvae were all upregulated. The expressions of PTH and TRVP6 positively correlated with the level of PCBs to which the embryos were exposed. These results suggest that embryonic exposure to PCBs induces developmental deficits in the zebrafish skeleton.

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Copy and paste a formatted citation
Spandidos Publications style
Ju L, Tang K, Guo X, Yang Y, Zhu G and Lou Y: Effects of embryonic exposure to polychlorinated biphenyls on zebrafish skeletal development. Mol Med Rep 5: 1227-1231, 2012.
APA
Ju, L., Tang, K., Guo, X., Yang, Y., Zhu, G., & Lou, Y. (2012). Effects of embryonic exposure to polychlorinated biphenyls on zebrafish skeletal development. Molecular Medicine Reports, 5, 1227-1231. https://doi.org/10.3892/mmr.2012.823
MLA
Ju, L., Tang, K., Guo, X., Yang, Y., Zhu, G., Lou, Y."Effects of embryonic exposure to polychlorinated biphenyls on zebrafish skeletal development". Molecular Medicine Reports 5.5 (2012): 1227-1231.
Chicago
Ju, L., Tang, K., Guo, X., Yang, Y., Zhu, G., Lou, Y."Effects of embryonic exposure to polychlorinated biphenyls on zebrafish skeletal development". Molecular Medicine Reports 5, no. 5 (2012): 1227-1231. https://doi.org/10.3892/mmr.2012.823
Copy and paste a formatted citation
x
Spandidos Publications style
Ju L, Tang K, Guo X, Yang Y, Zhu G and Lou Y: Effects of embryonic exposure to polychlorinated biphenyls on zebrafish skeletal development. Mol Med Rep 5: 1227-1231, 2012.
APA
Ju, L., Tang, K., Guo, X., Yang, Y., Zhu, G., & Lou, Y. (2012). Effects of embryonic exposure to polychlorinated biphenyls on zebrafish skeletal development. Molecular Medicine Reports, 5, 1227-1231. https://doi.org/10.3892/mmr.2012.823
MLA
Ju, L., Tang, K., Guo, X., Yang, Y., Zhu, G., Lou, Y."Effects of embryonic exposure to polychlorinated biphenyls on zebrafish skeletal development". Molecular Medicine Reports 5.5 (2012): 1227-1231.
Chicago
Ju, L., Tang, K., Guo, X., Yang, Y., Zhu, G., Lou, Y."Effects of embryonic exposure to polychlorinated biphenyls on zebrafish skeletal development". Molecular Medicine Reports 5, no. 5 (2012): 1227-1231. https://doi.org/10.3892/mmr.2012.823
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