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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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June 2012 Volume 5 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Loss of imprinting of IGF2 correlates with hypomethylation of the H19 differentially methylated region in the tumor tissue of colorectal cancer patients

  • Authors:
    • Fuliang Tian
    • Zhipeng Tang
    • Guoqi Song
    • Yuqin Pan
    • Bangshun He
    • Qian Bao
    • Shukui Wang

  • View Affiliations / Copyright

    Affiliations: Department of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu 210046, P.R. China, Central Laboratory of Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210006, P.R. China, Department of Hematology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 210046, P.R. China
  • Pages: 1536-1540
    |
    Published online on: March 13, 2012
       https://doi.org/10.3892/mmr.2012.833
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Abstract

Expression of the imprinted genes insulin-like growth factor 2 (IGF2) and H19 depends on the methylation pattern of their differentially methylated region (DMR) located on chromosome 11p15. In the present study, we examined the imprinting status of the IGF2 gene in 120 human colorectal cancer (CRC) patients and 150 normal controls. In addition, we analyzed the DNA methylation of the sixth CTCF-binding site in the DMR of IGF2/H19 in 81 CRC patients using bisulfate sequencing. Of a total of 81 informative (heterozygous) samples, 51 samples showed bialleic IGF2 expression in tumor samples; however, only 15 of 69 informative samples showed loss of imprinting (LOI) of IGF2 in normal controls. Statistically significant differences in the methylation status between the retention of imprinting (ROI) and LOI groups (66.1±14.9 vs. 16.7±9.2, p=0.008) were observed. The results of the present study suggest that LOI of IGF2 is important in the carcinogenesis of CRC. Hypomethylation of the sixth CTCF-binding site in the DMR of IGF2/H19 is linked to LOI and the common IGF2-H19 enhancer competition model for IGF2 imprinting does not apply to human CRC.

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Copy and paste a formatted citation
Spandidos Publications style
Tian F, Tang Z, Song G, Pan Y, He B, Bao Q and Wang S: Loss of imprinting of IGF2 correlates with hypomethylation of the H19 differentially methylated region in the tumor tissue of colorectal cancer patients. Mol Med Rep 5: 1536-1540, 2012.
APA
Tian, F., Tang, Z., Song, G., Pan, Y., He, B., Bao, Q., & Wang, S. (2012). Loss of imprinting of IGF2 correlates with hypomethylation of the H19 differentially methylated region in the tumor tissue of colorectal cancer patients. Molecular Medicine Reports, 5, 1536-1540. https://doi.org/10.3892/mmr.2012.833
MLA
Tian, F., Tang, Z., Song, G., Pan, Y., He, B., Bao, Q., Wang, S."Loss of imprinting of IGF2 correlates with hypomethylation of the H19 differentially methylated region in the tumor tissue of colorectal cancer patients". Molecular Medicine Reports 5.6 (2012): 1536-1540.
Chicago
Tian, F., Tang, Z., Song, G., Pan, Y., He, B., Bao, Q., Wang, S."Loss of imprinting of IGF2 correlates with hypomethylation of the H19 differentially methylated region in the tumor tissue of colorectal cancer patients". Molecular Medicine Reports 5, no. 6 (2012): 1536-1540. https://doi.org/10.3892/mmr.2012.833
Copy and paste a formatted citation
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Spandidos Publications style
Tian F, Tang Z, Song G, Pan Y, He B, Bao Q and Wang S: Loss of imprinting of IGF2 correlates with hypomethylation of the H19 differentially methylated region in the tumor tissue of colorectal cancer patients. Mol Med Rep 5: 1536-1540, 2012.
APA
Tian, F., Tang, Z., Song, G., Pan, Y., He, B., Bao, Q., & Wang, S. (2012). Loss of imprinting of IGF2 correlates with hypomethylation of the H19 differentially methylated region in the tumor tissue of colorectal cancer patients. Molecular Medicine Reports, 5, 1536-1540. https://doi.org/10.3892/mmr.2012.833
MLA
Tian, F., Tang, Z., Song, G., Pan, Y., He, B., Bao, Q., Wang, S."Loss of imprinting of IGF2 correlates with hypomethylation of the H19 differentially methylated region in the tumor tissue of colorectal cancer patients". Molecular Medicine Reports 5.6 (2012): 1536-1540.
Chicago
Tian, F., Tang, Z., Song, G., Pan, Y., He, B., Bao, Q., Wang, S."Loss of imprinting of IGF2 correlates with hypomethylation of the H19 differentially methylated region in the tumor tissue of colorectal cancer patients". Molecular Medicine Reports 5, no. 6 (2012): 1536-1540. https://doi.org/10.3892/mmr.2012.833
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