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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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June 2012 Volume 5 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Article

MPTP-induced model of Parkinson's disease in heat shock protein 70.1 knockout mice

  • Authors:
    • Hyun Kyung Park
    • Ah Rang Cho
    • Seung Chul Lee
    • Ju Yeon Ban

  • View Affiliations / Copyright

    Affiliations: Department of Emergency Medicine, School of Medicine, Kyung Hee University, Seoul, Republic of Korea, Department of Psychiatry, School of Medicine, Kyung Hee University, Seoul, Republic of Korea, Department of Emergency Medicine, Dongguk University Ilsan Hospital, Seoul, Republic of Korea, Department of Pharmacology, College of Dentistryand Institute of Tissue Regeneration Engineering, Dankook University, Cheonan, Republic of Korea
  • Pages: 1465-1468
    |
    Published online on: March 19, 2012
       https://doi.org/10.3892/mmr.2012.839
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Abstract

Heat shock proteins (HSPs), molecular chaperones that assist in protein folding, have become a research focus in Parkinson's disease (PD) since the pathogenesis of PD is characterized by intracellular protein misfolding and inclusion body formation. This study investigated the effect of the knockout (KO) of the Hsp70.1 (approved gene symbol Hspa1b) gene on the sensitivity of murine nigrostriatal dopaminergic neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced toxicity. We confirmed changes in motor coordination and tyrosine hydroxylase (TH) immunoreactivity in the substantia nigra following MPTP treatment of C57BL/6 normal mice and Hspa1b KO mice. MPTP treatment led to motor control impairment and induced TH-positive dopaminergic neurodegeneration in normal mice. Compared to untreated normal mice, rotarod duration and the density of TH-positive neurons in the substantia nigra were also significantly lower in untreated KO mice (p<0.01). MPTP-treated KO mice had markedly decreased rotarod duration and reduced density of TH-positive neurons, compared to MPTP-treated normal mice. These results indicate that Hspa1b KO mice are more vulnerable to the neurotoxic effects of MPTP and are consistent with the hypothesis that HSPs represent an important molecular target for neuroprotective strategies in the treatment of PD.

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Copy and paste a formatted citation
Spandidos Publications style
Park H, Cho A, Lee S and Ban J: MPTP-induced model of Parkinson's disease in heat shock protein 70.1 knockout mice. Mol Med Rep 5: 1465-1468, 2012.
APA
Park, H., Cho, A., Lee, S., & Ban, J. (2012). MPTP-induced model of Parkinson's disease in heat shock protein 70.1 knockout mice. Molecular Medicine Reports, 5, 1465-1468. https://doi.org/10.3892/mmr.2012.839
MLA
Park, H., Cho, A., Lee, S., Ban, J."MPTP-induced model of Parkinson's disease in heat shock protein 70.1 knockout mice". Molecular Medicine Reports 5.6 (2012): 1465-1468.
Chicago
Park, H., Cho, A., Lee, S., Ban, J."MPTP-induced model of Parkinson's disease in heat shock protein 70.1 knockout mice". Molecular Medicine Reports 5, no. 6 (2012): 1465-1468. https://doi.org/10.3892/mmr.2012.839
Copy and paste a formatted citation
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Spandidos Publications style
Park H, Cho A, Lee S and Ban J: MPTP-induced model of Parkinson's disease in heat shock protein 70.1 knockout mice. Mol Med Rep 5: 1465-1468, 2012.
APA
Park, H., Cho, A., Lee, S., & Ban, J. (2012). MPTP-induced model of Parkinson's disease in heat shock protein 70.1 knockout mice. Molecular Medicine Reports, 5, 1465-1468. https://doi.org/10.3892/mmr.2012.839
MLA
Park, H., Cho, A., Lee, S., Ban, J."MPTP-induced model of Parkinson's disease in heat shock protein 70.1 knockout mice". Molecular Medicine Reports 5.6 (2012): 1465-1468.
Chicago
Park, H., Cho, A., Lee, S., Ban, J."MPTP-induced model of Parkinson's disease in heat shock protein 70.1 knockout mice". Molecular Medicine Reports 5, no. 6 (2012): 1465-1468. https://doi.org/10.3892/mmr.2012.839
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