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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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June 2012 Volume 5 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

Renal protective effect of Rosa laevigata Michx. by the inhibition of oxidative stress in streptozotocin-induced diabetic rats

  • Authors:
    • Yujuan Zhou
    • Qianjin Liao
    • Yuping Luo
    • Zhenqi Qing
    • Qiuju Zhang
    • Guoping He

  • View Affiliations / Copyright

    Affiliations: Central South University, Changsha, Hunan 410083, P.R. China, University of South China, Hengyang, Hunan 421001, P.R. China, The Second Hospital of The University of South China, Hengyang, Hunan 421001, P.R. China
  • Pages: 1548-1554
    |
    Published online on: April 2, 2012
       https://doi.org/10.3892/mmr.2012.855
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Abstract

Diabetic nephropathy (DN) is a long-term complication of diabetic mellitus. Numerous reports have suggested that oxidative stress is defined as the excessive production of reactive oxygen species (ROS) surpassing existing anti-oxidative defense mechanisms, and plays a critical role in the pathogenesis of diabetic nephropathy. Rosa laevigata Michx. (RLM) is the commonly used traditional Chinese medicine for the treatment of chronic urinary tract infections and anti-oxidative treatments, and has been shown to have a renal protective effect in diabetic rats. In the present study, we further investigate the effects of RLM on oxidative stress in the kidneys of streptozotocin-induced diabetic rats with DN. Our results suggest that RLM significantly ameliorates renal dysfunction in diabetic rats. The protection against the development of DN by RLM treatment involves increasing the activity of superoxide dismutase and total anti-oxidant capacity, decreasing the levels of malondialdehyde and ROS, and inhibiting the expression of nuclear factor-κB p65 and monocyte chemoattractant protein-1 at both the protein and mRNA levels with a concomitant increase in the expression of the IκBα protein. These results highlight the potential therapeutic application of RLM for the treatment of DN.

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Copy and paste a formatted citation
Spandidos Publications style
Zhou Y, Liao Q, Luo Y, Qing Z, Zhang Q and He G: Renal protective effect of Rosa laevigata Michx. by the inhibition of oxidative stress in streptozotocin-induced diabetic rats. Mol Med Rep 5: 1548-1554, 2012.
APA
Zhou, Y., Liao, Q., Luo, Y., Qing, Z., Zhang, Q., & He, G. (2012). Renal protective effect of Rosa laevigata Michx. by the inhibition of oxidative stress in streptozotocin-induced diabetic rats. Molecular Medicine Reports, 5, 1548-1554. https://doi.org/10.3892/mmr.2012.855
MLA
Zhou, Y., Liao, Q., Luo, Y., Qing, Z., Zhang, Q., He, G."Renal protective effect of Rosa laevigata Michx. by the inhibition of oxidative stress in streptozotocin-induced diabetic rats". Molecular Medicine Reports 5.6 (2012): 1548-1554.
Chicago
Zhou, Y., Liao, Q., Luo, Y., Qing, Z., Zhang, Q., He, G."Renal protective effect of Rosa laevigata Michx. by the inhibition of oxidative stress in streptozotocin-induced diabetic rats". Molecular Medicine Reports 5, no. 6 (2012): 1548-1554. https://doi.org/10.3892/mmr.2012.855
Copy and paste a formatted citation
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Spandidos Publications style
Zhou Y, Liao Q, Luo Y, Qing Z, Zhang Q and He G: Renal protective effect of Rosa laevigata Michx. by the inhibition of oxidative stress in streptozotocin-induced diabetic rats. Mol Med Rep 5: 1548-1554, 2012.
APA
Zhou, Y., Liao, Q., Luo, Y., Qing, Z., Zhang, Q., & He, G. (2012). Renal protective effect of Rosa laevigata Michx. by the inhibition of oxidative stress in streptozotocin-induced diabetic rats. Molecular Medicine Reports, 5, 1548-1554. https://doi.org/10.3892/mmr.2012.855
MLA
Zhou, Y., Liao, Q., Luo, Y., Qing, Z., Zhang, Q., He, G."Renal protective effect of Rosa laevigata Michx. by the inhibition of oxidative stress in streptozotocin-induced diabetic rats". Molecular Medicine Reports 5.6 (2012): 1548-1554.
Chicago
Zhou, Y., Liao, Q., Luo, Y., Qing, Z., Zhang, Q., He, G."Renal protective effect of Rosa laevigata Michx. by the inhibition of oxidative stress in streptozotocin-induced diabetic rats". Molecular Medicine Reports 5, no. 6 (2012): 1548-1554. https://doi.org/10.3892/mmr.2012.855
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