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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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June 2012 Volume 5 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Antitumor activity of Chidamide in hepatocellular carcinoma cell lines

  • Authors:
    • Haijuan Wang
    • Yi Guo
    • Ming Fu
    • Xiao Liang
    • Xueyan Zhang
    • Renzhi Wang
    • Chen Lin
    • Haili Qian

  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Molecular Oncology, Cancer Institute/Hospital, CAMS and PUMC, Beijing, P.R. China, Department of Neurosurgery, Peking Union Hospital, Beijing, P.R. China
  • Pages: 1503-1508
    |
    Published online on: April 5, 2012
       https://doi.org/10.3892/mmr.2012.858
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Abstract

Chidamide, the structural analog of MS-275, is a novel and promising histone deacetylase (HDAC) inhibitor for use in cancer therapy. To investigate its effects on cancer cell growth, MTT assay was performed in 10 human cancer cell lines. The data showed that the IC50 of Chidamide ranged from 1 to 13 µM, which was comparable to that of MS-275 in half of the tested cell lines. Furthermore, the growth curve indicated that cell growth was gradually inhibited with an increase in Chidamide dosage, and the inhibition was reversed after drug removal in two hepatocelluclar carcinoma cell lines, BEL-7402 and HCC-9204. To determine cell cycle and apoptosis, FACS was carried out in the BEL-7402 and HCC-9204 cells treated with Chidamide. A decrease in the cell population at S phase and an increase in the cell population at G1 phase occurred in a dose-dependent manner. In addition, Chidamide induced apoptosis and up-regulated p21 mRNA expression. These results suggest that Chidamide may arrest the cell cycle and inhibit the growth of hepatocellular carcinoma cells through up-regulation of p21. Further studies are required to clarify the antitumor activity of Chidamide in vivo and its mechanism in anticancer therapy.

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Copy and paste a formatted citation
Spandidos Publications style
Wang H, Guo Y, Fu M, Liang X, Zhang X, Wang R, Lin C and Qian H: Antitumor activity of Chidamide in hepatocellular carcinoma cell lines. Mol Med Rep 5: 1503-1508, 2012.
APA
Wang, H., Guo, Y., Fu, M., Liang, X., Zhang, X., Wang, R. ... Qian, H. (2012). Antitumor activity of Chidamide in hepatocellular carcinoma cell lines. Molecular Medicine Reports, 5, 1503-1508. https://doi.org/10.3892/mmr.2012.858
MLA
Wang, H., Guo, Y., Fu, M., Liang, X., Zhang, X., Wang, R., Lin, C., Qian, H."Antitumor activity of Chidamide in hepatocellular carcinoma cell lines". Molecular Medicine Reports 5.6 (2012): 1503-1508.
Chicago
Wang, H., Guo, Y., Fu, M., Liang, X., Zhang, X., Wang, R., Lin, C., Qian, H."Antitumor activity of Chidamide in hepatocellular carcinoma cell lines". Molecular Medicine Reports 5, no. 6 (2012): 1503-1508. https://doi.org/10.3892/mmr.2012.858
Copy and paste a formatted citation
x
Spandidos Publications style
Wang H, Guo Y, Fu M, Liang X, Zhang X, Wang R, Lin C and Qian H: Antitumor activity of Chidamide in hepatocellular carcinoma cell lines. Mol Med Rep 5: 1503-1508, 2012.
APA
Wang, H., Guo, Y., Fu, M., Liang, X., Zhang, X., Wang, R. ... Qian, H. (2012). Antitumor activity of Chidamide in hepatocellular carcinoma cell lines. Molecular Medicine Reports, 5, 1503-1508. https://doi.org/10.3892/mmr.2012.858
MLA
Wang, H., Guo, Y., Fu, M., Liang, X., Zhang, X., Wang, R., Lin, C., Qian, H."Antitumor activity of Chidamide in hepatocellular carcinoma cell lines". Molecular Medicine Reports 5.6 (2012): 1503-1508.
Chicago
Wang, H., Guo, Y., Fu, M., Liang, X., Zhang, X., Wang, R., Lin, C., Qian, H."Antitumor activity of Chidamide in hepatocellular carcinoma cell lines". Molecular Medicine Reports 5, no. 6 (2012): 1503-1508. https://doi.org/10.3892/mmr.2012.858
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