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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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July 2012 Volume 6 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

WWOX-mediated apoptosis in A549 cells mainly involves the mitochondrial pathway

  • Authors:
    • Ping Zhang
    • Renbing Jia
    • Lei Ying
    • Bo Liu
    • Guanxiang Qian
    • Xianqun Fan
    • Shengfang Ge

  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry and Molecular Biology, Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China, Department of Ophthalmology, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China
  • Pages: 121-124
    |
    Published online on: April 6, 2012
       https://doi.org/10.3892/mmr.2012.860
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Abstract

The human WWOX gene, known as WW domain-containing oxidoreductase, is located on 16q23.3-24.1, a chromosome region that spans the common fragile site, FRA16D. Abnormal transcripts or even loss of expression are frequently found in a number of cancer cell types, including breast, ovarian, prostate and lung cancer cells. It has therefore been proposed that the WWOX gene encodes a candidate tumor suppressor, possibly a pro-apoptotic protein. However, the mechanism behind this is not entirely clear. In the present study, we examined the pro-apoptotic action of WWOX using transient expression in A549 cells. We observed that the ectopic expression of WWOX caused apoptosis in A549 cells. We further observed procaspase-3 and procaspase-9 activation and the release of cytochrome C from the mitochondria in A549 cells transfected with pcDNA3.0-WWOX. These data indicate that WWOX induces apoptosis in A549 cells via the mitochondrial pathway.

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Copy and paste a formatted citation
Spandidos Publications style
Zhang P, Jia R, Ying L, Liu B, Qian G, Fan X and Ge S: WWOX-mediated apoptosis in A549 cells mainly involves the mitochondrial pathway. Mol Med Rep 6: 121-124, 2012.
APA
Zhang, P., Jia, R., Ying, L., Liu, B., Qian, G., Fan, X., & Ge, S. (2012). WWOX-mediated apoptosis in A549 cells mainly involves the mitochondrial pathway. Molecular Medicine Reports, 6, 121-124. https://doi.org/10.3892/mmr.2012.860
MLA
Zhang, P., Jia, R., Ying, L., Liu, B., Qian, G., Fan, X., Ge, S."WWOX-mediated apoptosis in A549 cells mainly involves the mitochondrial pathway". Molecular Medicine Reports 6.1 (2012): 121-124.
Chicago
Zhang, P., Jia, R., Ying, L., Liu, B., Qian, G., Fan, X., Ge, S."WWOX-mediated apoptosis in A549 cells mainly involves the mitochondrial pathway". Molecular Medicine Reports 6, no. 1 (2012): 121-124. https://doi.org/10.3892/mmr.2012.860
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang P, Jia R, Ying L, Liu B, Qian G, Fan X and Ge S: WWOX-mediated apoptosis in A549 cells mainly involves the mitochondrial pathway. Mol Med Rep 6: 121-124, 2012.
APA
Zhang, P., Jia, R., Ying, L., Liu, B., Qian, G., Fan, X., & Ge, S. (2012). WWOX-mediated apoptosis in A549 cells mainly involves the mitochondrial pathway. Molecular Medicine Reports, 6, 121-124. https://doi.org/10.3892/mmr.2012.860
MLA
Zhang, P., Jia, R., Ying, L., Liu, B., Qian, G., Fan, X., Ge, S."WWOX-mediated apoptosis in A549 cells mainly involves the mitochondrial pathway". Molecular Medicine Reports 6.1 (2012): 121-124.
Chicago
Zhang, P., Jia, R., Ying, L., Liu, B., Qian, G., Fan, X., Ge, S."WWOX-mediated apoptosis in A549 cells mainly involves the mitochondrial pathway". Molecular Medicine Reports 6, no. 1 (2012): 121-124. https://doi.org/10.3892/mmr.2012.860
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