Correlation between serum H2S and pulmonary function in children with bronchial asthma

Tian,Man; Wang,Yu; Lu,Yue-Qing; Yan,Ming; Jiang,Yan-He; Zhao,De-Yu

doi:10.3892/mmr.2012.904

August 2012 Volume 6 Issue 2

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August 2012 Volume 6 Issue 2

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Article

Correlation between serum H2S and pulmonary function in children with bronchial asthma

Authors:
- Man Tian
- Yu Wang
- Yue-Qing Lu
- Ming Yan
- Yan-He Jiang
- De-Yu Zhao
View Affiliations / Copyright

Affiliations: Department of Respiratory Medicine, Nanjing Children's Hospital Affiliated with Nanjing Medical University, Nanjing, Jiangsu 210008, P.R. China
Pages: 335-338
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Published online on: May 4, 2012

https://doi.org/10.3892/mmr.2012.904
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Abstract

Endogenous hydrogen sulfide (H2S) has generated recent research interest because of its potential function as an inflammatory mediator. Despite its apparent functions in vascular smooth muscle, an important player in airway remodeling in asthma, little research has been done to assess the role of H2S in the pathogenesis of asthma. To determine whether serum H2S concentration is correlated with pulmonary function in children with asthma, we measured serum H2S concentration and pulmonary function indices (FVC, FEV1, PEF, FEF25-75, MEF50 and MEF25) in 64 children with asthma and 60 healthy children. Pearson's correlation was used to determine the relationship between serum H2S concentration and lung function parameters. Compared to healthy children, both serum H2S concentration and all lung function parameters were significantly decreased in children with asthma (P<0.05). Furthermore, serum H2S concentration was positively correlated with lung function indices (P<0.05). Thus, decreasing levels of H2S in the serum may be used to indicate decreasing lung function. Further investigation into the causality behind these findings is required.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Correlation between serum H2S and pulmonary function in children with bronchial asthma

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Abstract

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