Expression of podoplanin in salivary gland adenoid cystic carcinoma and its association with distant metastasis and clinical outcomes

Wu,He-Ming; Ren,Guo-Xin; Wang,Li-Zhen; Zhang,Chun-Ye; Chen,Wan-Tao; Guo,Wei

doi:10.3892/mmr.2012.911

Expression of podoplanin in salivary gland adenoid cystic carcinoma and its association with distant metastasis and clinical outcomes

Authors:
- He-Ming Wu
- Guo-Xin Ren
- Li-Zhen Wang
- Chun-Ye Zhang
- Wan-Tao Chen
- Wei Guo
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Affiliations: Department of Oral and Maxillofacial - Head and Neck Oncology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China, Department of Oral Pathology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China, Shanghai Key Laboratory of Stomatology, Department of Oral and Maxillofacial - Head and Neck Oncology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China
Published online on: May 9, 2012 https://doi.org/10.3892/mmr.2012.911
Pages: 271-274
Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

Distant metastasis is a common cause of mortality in patients with salivary gland adenoid cystic carcinoma (SACC). However, presently, the development of distant metastasis is unable to be predicted in clinical practice. Recent studies have shown that overexpression of podoplanin is associated with metastasis and survival in patients with several cancer types. The purpose of the present study was to determine whether podoplanin is overexpressed in SACC and whether such overexpression is associated with distant metastasis and survival. Podoplanin expression was determined using immunohistochemistry (IHC) in tumors from 40 SACC patients. The expression status was analyzed in regards to patient clinicopathological parameters and survival rates. Overexpression of podoplanin was detected in 13 (32.5%) of the 40 tumors. Overexpression was significantly associated with disease-free survival (P=0.025) and distant metastasis (P=0.015), although it was not associated with recurrence and overall survival. In conclusion, podoplanin is overexpressed in a subset of SACCs and may be a biomarker predicting distant metastasis in patients with SACC.

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1	Li J, Wang BY, Nelson M, et al: Salivary adenocarcinoma, not otherwise specified: a collection of orphans. Arch Pathol Lab Med. 128:1385–1394. 2004.PubMed/NCBI
2	Bradley PJ: Adenoid cystic carcinoma of the head and neck: a review. Curr Opin Otolaryngol Head Neck Surg. 12:127–132. 2004. View Article : Google Scholar : PubMed/NCBI
3	Sung MW, Kim KH, Kim JW, et al: Clinicopathological predictors and impact of distant metastasis from adenoid cystic carcinoma of the head and neck. Arch Otolaryngol Head Neck Surg. 129:1193–1197. 2003. View Article : Google Scholar : PubMed/NCBI
4	Khan AJ, DiGiovanna MP, Ross DA, et al: Adenoid cystic carcinoma: a retrospective clinical review. Int J Cancer. 96:149–158. 2001. View Article : Google Scholar : PubMed/NCBI
5	Nascimento AG, Amaral AL, Prado LA, Kligerman J and Silveira TR: Adenoid cystic carcinoma of salivary glands. A study of 61 cases with clinicopathological correlation. Cancer. 57:312–319. 1986. View Article : Google Scholar : PubMed/NCBI
6	Spiro RH, Huvos AG and Strong EW: Adenoid cystic carcinoma of salivary origin. A clinicopathological study of 242 cases. Am J Surg. 128:512–520. 1974. View Article : Google Scholar : PubMed/NCBI
7	Spiro RH: Distant metastasis in adenoid cystic carcinoma of salivary origin. Am J Surg. 174:495–498. 1997. View Article : Google Scholar : PubMed/NCBI
8	da Cruz Perez DE, de Abreu Alves F, Nobuko Nishimoto I, de Almeida OP and Kowalski LP: Prognostic factors in head and neck adenoid cystic carcinoma. Oral Oncol. 42:139–146. 2006.PubMed/NCBI
9	Kahn HJ and Marks A: A new monoclonal antibody, D2-40, for detection of lymphatic invasion in primary tumors. Lab Invest. 82:1255–1257. 2002. View Article : Google Scholar : PubMed/NCBI
10	Schacht V, Ramirez MI, Hong YK, et al: T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema. EMBO J. 22:3546–3556. 2003. View Article : Google Scholar : PubMed/NCBI
11	Marks A, Sutherland DR, Bailey D, et al: Characterization and distribution of an oncofetal antigen (M2A antigen) expressed on testicular germ cell tumours. Br J Cancer. 80:569–578. 1999. View Article : Google Scholar : PubMed/NCBI
12	Yuan P, Temam S, El-Naggar A, et al: Overexpression of podoplanin in oral cancer and its association with poor clinical outcome. Cancer. 107:563–569. 2006. View Article : Google Scholar : PubMed/NCBI
13	Dumoff KL, Chu C, Xu X, Pasha T, Zhang PJ and Acs G: Low D2-40 immunoreactivity correlates with lymphatic invasion and nodal metastasis in early-stage squamous cell carcinoma of the uterine cervix. Mod Pathol. 18:97–104. 2005. View Article : Google Scholar : PubMed/NCBI
14	Schacht V, Dadras SS, Johnson LA, Jackson DG, Hong YK and Detmar M: Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors. Am J Pathol. 166:913–921. 2005. View Article : Google Scholar : PubMed/NCBI
15	Wicki A and Christofori G: The potential role of podoplanin in tumour invasion. Br J Cancer. 96:1–5. 2007. View Article : Google Scholar : PubMed/NCBI
16	Dardick I: Adenoid cystic carcinoma. Color Atlas/Text of Salivary Gland Tumor Pathology. Igaku-Shoin Medical Publishers; New York, NY: pp. 149–161. 1996
17	Sobin LH and Wittekind C: TNM Classification of Malignant Tumors. 6th edition. John Wiley & Sons; New York, NY: 2002
18	Hata M, Amano I, Tsuruga E, Kojima H and Sawa Y: Immunoelectron microscopic study of podoplanin localization in mouse salivary gland myoepithelium. Acta Histochem Cytochem. 43:77–82. 2010. View Article : Google Scholar : PubMed/NCBI
19	Hata M, Ueki T, Sato A, Kojima H and Sawa Y: Expression of podoplanin in the mouse salivary glands. Arch Oral Biol. 53:835–841. 2008. View Article : Google Scholar : PubMed/NCBI
20	Fujita G, Sato S, Kishino M, Iwai S, Nakazawa M, Toyosawa S, Yura Y and Ogawa Y: Lymphatic vessels and related factors in adenoid cystic carcinoma of the salivary gland. Mod Pathol. 24:885–891. 2011. View Article : Google Scholar : PubMed/NCBI