Correlation between atrial fibrillation, serum amyloid protein A and other inflammatory cytokines

Cheng,Tao; Wang,Xiao-Fei; Hou,Yun-Tian; Zhang,Li

doi:10.3892/mmr.2012.934

September 2012 Volume 6 Issue 3

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September 2012 Volume 6 Issue 3

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Article

Correlation between atrial fibrillation, serum amyloid protein A and other inflammatory cytokines

Authors:
- Tao Cheng
- Xiao-Fei Wang
- Yun-Tian Hou
- Li Zhang
View Affiliations / Copyright

Affiliations: Beijing Institute of Transfusion Medicine, Beijing 100850, P.R. China, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, P.R. China, 301st Hospital of Beijing, Beijing 100850, P.R. China, Shandong University, Jinan 250012, P.R. China
Pages: 581-584
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Published online on: June 6, 2012

https://doi.org/10.3892/mmr.2012.934
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Abstract

Atrial fibrillation (AF) may occur and persist due to atrial remodeling exacerbated by inflammation. However, whether inflammatory cytokines, such as serum amyloid protein A (SAA), are elevated in patients with atrial arrhythmias remains unclear. In a case-control study design, serum levels of inflammatory cytokines SAA, IL-1, IL-6, TNF-α and high-sensitivity C-reactive protein (hsCRP) were compared between 122 patients with AF and 63 non-AF controls. Of 122 AF patients, 48 had lone AF and 74 organic AF; 65 had paroxysmal AF, 36 persistent AF and 21 permanent AF. In unadjusted analyses, the levels of SAA, hsCRP, TNF-αP, IL-1 and IL-6 were significantly higher in AF patients compared to control patients (P<0.01). Patients with permanent and persistent AF had higher serum levels of inflammatory cytokines than those with paroxysmal AF; all AF patients had higher serum levels than controls (P<0.05). Using a multivariate logistic regression analysis, we found that SAA (OR 3.11; 95% CI, 1.12-6.05), hsCRP (OR 2.53; 95% CI, 1.17-4.38), TNF-α (OR 1.80; 95% CI, 1.03-3.20) and IL-6 (OR 1.21; 95% CI, 0.68-2.87) were correlated with AF (P<0.05). SAA and related inflammatory cytokines are elevated in AF patients. This study is the first to document elevated SAA in AF patients. Although the cause of elevated SAA levels in AF patients remains unknown, elevated SAA may reflect an inflammatory state that promotes the occurrence and persistence of AF.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Correlation between atrial fibrillation, serum amyloid protein A and other inflammatory cytokines

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