Role of hsa-miR-325 in the etiopathology of preeclampsia

Lázár,Levente; Nagy,Bálint; Molvarec,Attila; Szarka,András; Rigó,János

doi:10.3892/mmr.2012.954

September 2012 Volume 6 Issue 3

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September 2012 Volume 6 Issue 3

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Article

Role of hsa-miR-325 in the etiopathology of preeclampsia

Authors:
- Levente Lázár
- Bálint Nagy
- Attila Molvarec
- András Szarka
- János Rigó
View Affiliations / Copyright

Affiliations: First Department of Obstetrics and Gynecology, Semmelweis University Budapest, H-1085 Budapest, Hungary
Pages: 597-600
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Published online on: June 18, 2012

https://doi.org/10.3892/mmr.2012.954
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Abstract

Preeclampsia (PE) is a common pregnancy-specific syndrome characterized by hypertension and proteinuria. Evidence has demonstrated that hypertensive disorders in pregnancy are associated with alterations in the expression of different microRNAs (miRNAs). miRNAs are endogenously expressed non-coding RNAs that have significant biological and pathological functions due to their potential mechanisms of regulation of gene expression. The purpose of the present study was to investigate the expression of hsa-miR-325 in placental samples of preeclamptic and uncomplicated pregnancy patients. hsa-miR-325 was isolated from placenta tissue samples obtained from 31 preeclamptic and 28 normotensive pregnant females. Quantitative real-time polymerase chain reaction was used to analyze miRNA expression. The expression of hsa-miR‑325 was elevated in uncomplicated pregnancies compared with preeclamptic patients. ΔCt (mean ± SD) values were 0.117±0.07 in PE tissues and 0.135±0.051 in normotensive cases (p<0.05). The expression levels correlated with patient blood pressure (p=0.015, r=-0.23), and tended to correlate with body mass index (p=0.065, r=0.261). The expression of hsa-miR-325 was downregulated in the case of PE. Changes in hsa-miR‑325 expression in the case of pregnancy-related hypertensive disorders might affect the oxidative stress pathways and heat-shock protein production. These factors have a strong correlation with the development of PE. We, therefore, suggest that hsa-miR-325 contributes to the pathogenesis of PE.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Role of hsa-miR-325 in the etiopathology of preeclampsia

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