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September 2012 Volume 6 Issue 3

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Article

Correlation between ischemia-modified albumin and lipid levels in patients with acute cerebrovascular disease

  • Authors:
    • Kun Han
    • Ning Jia
    • Li Yang
    • Lian-Qiu Min
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, The First Affiliated Hospital of Liaoning Medical College, Jinzhou, Liaoning 121001, P.R. China
  • Pages: 621-624
    |
    Published online on: June 21, 2012
       https://doi.org/10.3892/mmr.2012.961
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Abstract

Acute cerebrovascular disease (ACVD) is associated with high morbidity and mortality rates, however, molecular markers to aid in its early detection are lacking. In this study, we examined the correlation between serum ischemia-modified albumin (IMA), a marker used to identify ischemic events in the heart, and blood lipids in patients with ACVD. Serum IMA levels were determined by enzyme-linked immuno­sorbent assay, and total cholesterol (TC), low-density lipoprotein (LDL), high‑density lipoprotein cholesterol (HDL) and triglyceride (TG) levels were determined biochemically in 62 patients with cerebral infarction (CI), 40 patients with intracerebral hemorrhage (ICH), 18 patients with subarachnoid hemorrhage (SAH) and 100 healthy individuals (controls). Serum IMA levels were significantly higher in each of the ACVD groups compared to the control group (CI, 80.81±11.97 U/ml; ICH, 80.25±10.91 U/ml; SAH, 74.43±11.39 U/ml and control, 41.08±5.10 U/ml; P<0.05). Additionally, serum TC, LDL and TG levels significantly increased, while serum HDL significantly decreased in the ACVD groups compared to the control group (P<0.05). A positive correlation was found between serum IMA levels and serum TC, LDL and TG levels in the ACVD patients, while serum IMA levels were negatively correlated with serum HDL levels (P<0.05). Thus, serum IMA increased following an ACVD event and was closely correlated with changes in the blood lipid levels. These factors, when combined, may allow the development of molecular markers for an earlier diagnosis of ACVD.
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Copy and paste a formatted citation
Spandidos Publications style
Han K, Jia N, Yang L and Min L: Correlation between ischemia-modified albumin and lipid levels in patients with acute cerebrovascular disease. Mol Med Rep 6: 621-624, 2012.
APA
Han, K., Jia, N., Yang, L., & Min, L. (2012). Correlation between ischemia-modified albumin and lipid levels in patients with acute cerebrovascular disease. Molecular Medicine Reports, 6, 621-624. https://doi.org/10.3892/mmr.2012.961
MLA
Han, K., Jia, N., Yang, L., Min, L."Correlation between ischemia-modified albumin and lipid levels in patients with acute cerebrovascular disease". Molecular Medicine Reports 6.3 (2012): 621-624.
Chicago
Han, K., Jia, N., Yang, L., Min, L."Correlation between ischemia-modified albumin and lipid levels in patients with acute cerebrovascular disease". Molecular Medicine Reports 6, no. 3 (2012): 621-624. https://doi.org/10.3892/mmr.2012.961
Copy and paste a formatted citation
x
Spandidos Publications style
Han K, Jia N, Yang L and Min L: Correlation between ischemia-modified albumin and lipid levels in patients with acute cerebrovascular disease. Mol Med Rep 6: 621-624, 2012.
APA
Han, K., Jia, N., Yang, L., & Min, L. (2012). Correlation between ischemia-modified albumin and lipid levels in patients with acute cerebrovascular disease. Molecular Medicine Reports, 6, 621-624. https://doi.org/10.3892/mmr.2012.961
MLA
Han, K., Jia, N., Yang, L., Min, L."Correlation between ischemia-modified albumin and lipid levels in patients with acute cerebrovascular disease". Molecular Medicine Reports 6.3 (2012): 621-624.
Chicago
Han, K., Jia, N., Yang, L., Min, L."Correlation between ischemia-modified albumin and lipid levels in patients with acute cerebrovascular disease". Molecular Medicine Reports 6, no. 3 (2012): 621-624. https://doi.org/10.3892/mmr.2012.961
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