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Article

Single-nucleotide polymorphisms in the TSPYL-4 and NT5DC1 genes are associated with susceptibility to chronic obstructive pulmonary disease

  • Authors:
    • Yi Guo
    • Yi Gong
    • Guochao Shi
    • Kun Yang
    • Chunming Pan
    • Min Li
    • Qingyun Li
    • Qijian Cheng
    • Ranran Dai
    • Liang Fan
    • Huanying Wan
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University (SJTU), School of Medicine, Shanghai 200025, P.R. China, Department of Respiratory Medicine, Huashan Hospital, Fudan University, Shanghai 200025, P.R. China, Ruijin Hospital, State Key Laboratory of Medical Genomics, Molecular Medicine Center, Shanghai Jiao Tong University (SJTU), School of Medicine, Shanghai 200025, P.R. China
  • Pages: 631-638
    |
    Published online on: June 25, 2012
       https://doi.org/10.3892/mmr.2012.964
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Abstract

The risk of developing chronic obstructive pulmonary disease (COPD) is partially determined by genetic and environmental factors. Many published candidate gene studies show conflicting results due to ethnic differences and sample sizes. The number of these studies carried out in Chinese populations is small. To investigate candidate genes and haplotypes for susceptibility to COPD in a southern Han Chinese population, we performed genotyping of DNA samples in 200 COPD patients and 250 control subjects by analyzing 54 single-nucleotide polymorphisms (SNPs) in 23 genes associated with the development of COPD and/or pulmonary function identified by genome-wide association studies (GWAS). We also performed linkage disequilibrium (LD) and haplotype analysis according to the results of genotyping. The frequencies of the SNP [rs3749893 of testis‑specific protein Y-encoded-like 4 (TSPYL-4) gene] G allele and SNP [rs1052443 of 5'-nucleotidase domain containing 1 (NT5DC1) gene] A allele were significantly higher in the cases studied compared to the control subjects (P=0.032, P<0.05, OR=0.692, 95% CI 0.495‑0.970; P=0.0205, P<0.05, OR=0.670, 95% CI 0.477-0.941, respectively). Results showed that two blocks of SNPs (rs1052443 and rs3749893; rs11155242 and rs6937121) had sufficient precision to allow construction of a haplotype block. We constructed the TSPYL-4 and NT5DC1 haplotypes of the cases and controls, but no significant difference between the two groups was found. rs3749893 A allele of TSPYL-4 and rs1052443 C allele of NT5DC1 were associated with a protective effect against the deterioration of pulmonary function. In conclusion, TSPYL-4 and NT5DC1 gene polymorphisms are associated with susceptibility to COPD and pulmonary function.
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1 

Murray CJ and Lopez AD: Alternative projections of mortality and disability by cause 1990–2020: global burden of disease study. Lancet. 349:1498–1504. 1997.PubMed/NCBI

2 

Anthonisen NR, Connett JE, Kiley JP, Altose MD, Bailey WC, Buist AS, Conway WA Jr, Enright PL, Kanner RE, O’Hara P, et al: Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1. The lung health study. JAMA. 272:1497–1505. 1994. View Article : Google Scholar : PubMed/NCBI

3 

Siafakas NM, Vermeire P, Pride NB, Paoletti P, Gibson J, Howard P, Yernault JC, Decramer M, Higenbottam T, Postma DS, et al: Optimal assessment and management of chronic obstructive pulmonary disease (COPD). The European Respiratory Society Task Force. Eur Respir J. 8:1398–1420. 1995. View Article : Google Scholar : PubMed/NCBI

4 

Wang X, Li L, Xiao J, Jin C, Huang K, Kang X, Wu X and Lv F: Association of ADAM33 gene polymorphisms with COPD in a northeastern Chinese population. BMC Med Genet. 10:132–138. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Cigarette smoking and health. American Thoracic Society. Am J Respir Crit Care Med. 153:861–865. 1996. View Article : Google Scholar

6 

Hodge S, Hodge G, Holmes M and Reynolds PN: Increased airway epithelial and T-cell apoptosis in COPD remains despite smoking cessation. Eur Respir J. 25:447–454. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Silverman EK: Progress in chronic obstructive pulmonary disease genetics. Proc Am Thorac Soc. 3:405–408. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Silverman EK, Chapman HA, Drazen JM, Weiss ST, Rosner B, Campbell EJ, O’Donnell WJ, Reilly JJ, Ginns L, Mentzer S, Wain J and Speizer FE: Genetic epidemiology of severe, early-onset chronic obstructive pulmonary disease. Risk to relatives for airflow obstruction and chronic bronchitis. Am J Respir Crit Care Med. 157:1770–1778. 1998. View Article : Google Scholar

9 

Silverman EK, Mosley JD, Palmer LJ, Barth M, Senter JM, Brown A, Drazen JM, Kwiatkowski DJ, Chapman HA, Campbell EJ, et al: Genome-wide linkage analysis of severe, early-onset chronic obstructive pulmonary disease: airflow obstruction and chronic bronchitis phenotypes. Hum Mol Genet. 11:623–632. 2002. View Article : Google Scholar

10 

DeMeo DL, Celedón JC, Lange C, Reilly JJ, Chapman HA, Sylvia JS, Speizer FE, Weiss ST and Silverman EK: Genome-wide linkage of forced mid-expiratory flow in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 170:1294–1301. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Silverman EK, Palmer LJ, Mosley JD, Barth M, Senter JM, Brown A, Drazen JM, Kwiatkowski DJ, Chapman HA, Campbell EJ, et al: Genomewide linkage analysis of quantitative spirometric phenotypes in severe early-onset chronic obstructive pulmonary disease. Am J Hum Genet. 70:1229–1239. 2002. View Article : Google Scholar

12 

Wilk JB, Chen TH, Gottlieb DJ, Walter RE, Nagle MW, Brandler BJ, Myers RH, Borecki IB, Silverman EK, Weiss ST and O’Connor GT: A genome-wide association study of pulmonary function measures in the Framingham Heart Study. PLoS Genet. 5:e10004292009. View Article : Google Scholar : PubMed/NCBI

13 

Pillai SG, Ge D, Zhu G, Kong X, Shianna KV, Need AC, Feng S, Hersh CP, Bakke P, Gulsvik A, et al: A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. PLoS Genet. 5:e10004212009. View Article : Google Scholar : PubMed/NCBI

14 

Hancock DB, Eijgelsheim M, Wilk JB, Gharib SA, Loehr LR, Marciante KD, Franceschini N, van Durme YM, Chen TH, Barr RG, et al: Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. Nat Genet. 42:45–52. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Cho MH, Boutaoui N, Klanderman BJ, Sylvia JS, Ziniti JP, Hersh CP, DeMeo DL, Hunninghake GM, Litonjua AA, Sparrow D, et al: Variants in FAM13A are associated with chronic obstructive pulmonary disease. Nat Genet. 42:200–202. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Repapi E, Sayers I, Wain LV, Burton PR, Johnson T, Obeidat M, Zhao JH, Ramasamy A, Zhai G, Vitart V, et al: Genome-wide association study identifies five loci associated with lung function. Nat Genet. 42:36–44. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Rabe KF, Hurd S, Anzueto A, Barnes PJ, Buist SA, Calverley P, Fukuchi Y, Jenkins C, Rodriguez-Roisin R, van Weel C and Zielinski J: Global Initiative for Chronic Obstructive Lung Disease: Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med. 176:532–555. 2007. View Article : Google Scholar

18 

Gong Y, Fan L, Wan H, Shi Y, Shi G, Feng Y, Liu J, Ni L, Pan C and Zhang R: Lack of association between the TGF-β(1) gene and development of COPD in Asians: a case-control study and meta-analysis. Lung. 189:213–223. 2011.

19 

Edwards MC and Gibbs RA: Multiplex PCR: advantages, development, and applications. Genome Res. 3:S65–S75. 1994. View Article : Google Scholar : PubMed/NCBI

20 

Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, Higgins J, DeFelice M, Lochner A, Faggart M, et al: The structure of haplotype blocks in the human genome. Science. 296:2225–2229. 2002. View Article : Google Scholar : PubMed/NCBI

21 

Klein RJ, Zeiss C, Chew EY, Tsai JY, Sackler RS, Haynes C, Henning AK, SanGiovanni JP, Mane SM, Mayne ST, et al: Complement factor H polymorphism in age-related macular degeneration. Science. 308:385–389. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Cantor RM, Lange K and Sinsheimer JS: Prioritizing GWAS results: a review of statistical methods and recommendations for their application. Am J Hum Genet. 86:6–22. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Melen E, Himes BE, Brehm JM, Weiss ST and Lasky-Su J: Limited evidence for shared genetic factors between asthma and obesity based on known candidate genes. Am J Respir Crit Care Med. 181:A13052010.

24 

Frayling TM: Genome-wide association studies provide new insights into type 2 diabetes aetiology. Nat Rev Genet. 8:657–662. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Hinney A, Nguyen TT, Scherag A, Friedel S, Brönner G, Müller TD, Grallert H, Illig T, Wichmann HE, Rief W, Schäfer H and Hebebrand J: Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants. PLoS One. 2:e13612007. View Article : Google Scholar : PubMed/NCBI

26 

The Psychiatric GWAS Consortium Steering Committee. A framework for interpreting genome-wide association studies of psychiatric disorders. Mol Psychiatry. 14:10–17. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Vogel T, Dittrich O, Mehraein Y, Dechend F, Schnieders F and Schmidtke J: Murine and human TSPYL genes: novel members of the TSPY-SET-NAP1L1 family. Cytogenet Cell Genet. 81:265–270. 1998. View Article : Google Scholar : PubMed/NCBI

28 

von Lindern M, van Baal V, Wiegant J, Raap A, Hagemeijer A and Grosveld G: Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3′ half to different genes: characterization of the set gene. Mol Cell Biol. 12:3346–3355. 1992.PubMed/NCBI

29 

Puffenberger EG, Hu-Lince D, Parod JM, Craig DW, Dobrin SE, Conway AR, Donarum EA, Strauss KA, Dunckley T, Cardenas JF, et al: Mapping of sudden infant death with dysgenesis of the testes syndrome (SIDDT) by a SNP genome scan and indentification of TSPYL loss of function. Proc Natl Acad Sci USA. 101:11689–11694. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Vinci G, Brauner R, Tar A, et al: Mutations in the TSPYL1 gene associated with 46,XY disorder of sex development and male infertility. Fertil Steril. 92:1347–1350. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Kim TY, Zhong S, Fields CR, Fields RC, Kim JH and Robertson KD: Epigenomic profiling reveals novel and frequent targets of aberrant DNA methylation-mediated silencing in malignant glioma. Cancer Res. 66:7490–7501. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Jung Y, Park J, Bang YJ and Kim TY: Gene silencing of TSPYL5 mediated by aberrant promoter methylation in gastric cancers. Lab Invest. 88:153–160. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Kim EJ, Lee SY, Kim TR, Choi SI, Cho EW, Kim KC and Kim IJ: TSPYL5 is involved in cell growth and the resistance to radiation in A549 cells via the regulation of p21(WAF1/Cip1) and PTEN/AKT pathway. Biochem Biophys Res Commun. 392:448–453. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Bitto E, Bingman CA, Wesenberg GE, McCoy JG and Phillips GN Jr: Structure of pyrimidine 5′-nucleotidase type 1. Insight into mechanism of action and inhibition during lead poisoning. J Biol Chem. 281:20521–20529. 2006.

35 

Kim WJ, Hersh CP, DeMeo DL, Reilly JJ and Silverman EK: Genetic association analysis of COPD candidate genes with bronchodilator responsiveness. Respir Med. 103:552–557. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Zhu G, Warren L, Aponte J, Gulsvik A, Bakke P, Anderson WH, Lomas DA, Silverman EK and Pillai SG; International COPD Genetics Network (ICGN) Investigators. The SERPINE2 gene is associated with chronic obstructive pulmonary disease in two large population. Am J Respir Crit Care Med. 176:167–173. 2007. View Article : Google Scholar : PubMed/NCBI

37 

DeMeo D, Mariani T, Lange C, Lake S, Litonjua A, Celedón J, Reilly J, Chapman HA, Sparrow D, Spira A, et al: The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Proc Am Thorac Soc. 3:5022006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Guo Y, Gong Y, Shi G, Yang K, Pan C, Li M, Li Q, Cheng Q, Dai R, Fan L, Fan L, et al: Single-nucleotide polymorphisms in the TSPYL-4 and NT5DC1 genes are associated with susceptibility to chronic obstructive pulmonary disease. Mol Med Rep 6: 631-638, 2012.
APA
Guo, Y., Gong, Y., Shi, G., Yang, K., Pan, C., Li, M. ... Wan, H. (2012). Single-nucleotide polymorphisms in the TSPYL-4 and NT5DC1 genes are associated with susceptibility to chronic obstructive pulmonary disease. Molecular Medicine Reports, 6, 631-638. https://doi.org/10.3892/mmr.2012.964
MLA
Guo, Y., Gong, Y., Shi, G., Yang, K., Pan, C., Li, M., Li, Q., Cheng, Q., Dai, R., Fan, L., Wan, H."Single-nucleotide polymorphisms in the TSPYL-4 and NT5DC1 genes are associated with susceptibility to chronic obstructive pulmonary disease". Molecular Medicine Reports 6.3 (2012): 631-638.
Chicago
Guo, Y., Gong, Y., Shi, G., Yang, K., Pan, C., Li, M., Li, Q., Cheng, Q., Dai, R., Fan, L., Wan, H."Single-nucleotide polymorphisms in the TSPYL-4 and NT5DC1 genes are associated with susceptibility to chronic obstructive pulmonary disease". Molecular Medicine Reports 6, no. 3 (2012): 631-638. https://doi.org/10.3892/mmr.2012.964
Copy and paste a formatted citation
x
Spandidos Publications style
Guo Y, Gong Y, Shi G, Yang K, Pan C, Li M, Li Q, Cheng Q, Dai R, Fan L, Fan L, et al: Single-nucleotide polymorphisms in the TSPYL-4 and NT5DC1 genes are associated with susceptibility to chronic obstructive pulmonary disease. Mol Med Rep 6: 631-638, 2012.
APA
Guo, Y., Gong, Y., Shi, G., Yang, K., Pan, C., Li, M. ... Wan, H. (2012). Single-nucleotide polymorphisms in the TSPYL-4 and NT5DC1 genes are associated with susceptibility to chronic obstructive pulmonary disease. Molecular Medicine Reports, 6, 631-638. https://doi.org/10.3892/mmr.2012.964
MLA
Guo, Y., Gong, Y., Shi, G., Yang, K., Pan, C., Li, M., Li, Q., Cheng, Q., Dai, R., Fan, L., Wan, H."Single-nucleotide polymorphisms in the TSPYL-4 and NT5DC1 genes are associated with susceptibility to chronic obstructive pulmonary disease". Molecular Medicine Reports 6.3 (2012): 631-638.
Chicago
Guo, Y., Gong, Y., Shi, G., Yang, K., Pan, C., Li, M., Li, Q., Cheng, Q., Dai, R., Fan, L., Wan, H."Single-nucleotide polymorphisms in the TSPYL-4 and NT5DC1 genes are associated with susceptibility to chronic obstructive pulmonary disease". Molecular Medicine Reports 6, no. 3 (2012): 631-638. https://doi.org/10.3892/mmr.2012.964
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