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Article

Activation of Wnt signaling inhibits the pro-apoptotic role of Notch in gastric cancer cells

  • Authors:
    • Hong Li
    • Juan Mo
    • Guizhi Jia
    • Chao Liu
    • Zhidong Luan
    • Yifu Guan
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry and Molecular Biology, China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of Biochemistry and Molecular Biology, Liaoning Medical University, Jinzhou, Liaoning 121000, P.R. China
  • Pages: 1751-1756
    |
    Published online on: April 3, 2013
       https://doi.org/10.3892/mmr.2013.1412
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Abstract

Notch and Wnt signaling play critical roles in the regulation of development and diseases. Several studies have previously reported that Notch may be a therapeutic target in the treatment of various types of human cancer. In this study, we report that activation of Notch1 inhibits the proliferation of BGC-823 gastric cancer cells. However, the activation of the Wnt/β‑catenin signaling pathway promotes the growth of BGC-823 cells. Furthermore, the combinational activation of the two signaling pathways promotes the proliferation of BGC-823 cells. These data suggest that the activation of Wnt signaling overcomes the pro-apoptotic role of Notch in BGC-823 gastric cancer cells.
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1 

Ushijima T and Sasako M: Focus on gastric cancer. Cancer Cell. 5:121–125. 2004. View Article : Google Scholar

2 

Gonzalez CA, Sala N and Capella G: Genetic susceptibility and gastric cancer risk. Int J Cancer. 100:249–260. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Guo JL, Zheng SJ, Li YN, et al: Toxicarioside A inhibits SGC-7901 proliferation, migration and invasion via NF-kappaB/bFGF signaling. World J Gastroenterol. 18:1602–1609. 2012. View Article : Google Scholar : PubMed/NCBI

4 

El-Rifai W and Powell SM: Molecular biology of gastric cancer. Semin Radiat Oncol. 12:128–140. 2002. View Article : Google Scholar

5 

Smith MG, Hold GL, Tahara E and El-Omar EM: Cellular and molecular aspects of gastric cancer. World J Gastroenterol. 12:2979–2990. 2006.

6 

Kang MH, Oh SC, Lee HJ, Kang HN, Kim JL, Kim JS and Yoo YA: Metastatic function of BMP-2 in gastric cancer cells: the role of PI3K/AKT, MAPK, the NF-kappaB pathway, and MMP-9 expression. Exp Cell Res. 317:1746–1762. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Maloum F, Allaire JM, Gagne-Sansfacon J, et al: Epithelial BMP signaling is required for proper specification of epithelial cell lineages and gastric endocrine cells. Am J Physiol Gastrointest Liver Physiol. 300:G1065–G1079. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Martin J, Donnelly JM, Houghton J and Zavros Y: The role of sonic hedgehog reemergence during gastric cancer. Dig Dis Sci. 55:1516–1524. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Hsu KW, Hsieh RH, Huang KH, et al: Activation of the Notch1/STAT3/Twist signaling axis promotes gastric cancer progression. Carcinogenesis. 33:1459–1467. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Radulescu S, Ridgway RA, Cordero J, et al: Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation. Oncogene. Jun 4–2012.(Epub ahead of print). View Article : Google Scholar

11 

Kim TH and Shivdasani RA: Notch signaling in stomach epithelial stem cell homeostasis. J Exp Med. 208:677–688. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Sun Y, Gao X, Liu J, et al: Differential Notch1 and Notch2 expression and frequent activation of Notch signaling in gastric cancers. Arch Pathol Lab Med. 135:451–458. 2011.PubMed/NCBI

13 

Yeh TS, Wu CW, Hsu KW, et al: The activated Notch1 signal pathway is associated with gastric cancer progression through cyclooxygenase-2. Cancer Res. 69:5039–5048. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Katoh M: Notch ligand, JAG1, is evolutionarily conserved target of canonical WNT signaling pathway in progenitor cells. Int J Mol Med. 17:681–685. 2006.PubMed/NCBI

15 

Piazzi G, Fini L, Selgrad M, et al: Epigenetic regulation of Delta-Like1 controls Notch1 activation in gastric cancer. Oncotarget. 2:1291–1301. 2011.PubMed/NCBI

16 

Artavanis-Tsakonas S, Rand MD and Lake RJ: Notch signaling: cell fate control and signal integration in development. Science. 284:770–776. 1999. View Article : Google Scholar : PubMed/NCBI

17 

Roy M, Pear WS and Aster JC: The multifaceted role of Notch in cancer. Curr Opin Genet Dev. 17:52–59. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Kadesch T: Notch signaling: the demise of elegant simplicity. Curr Opin Genet Dev. 14:506–512. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Barth AI, Nathke IS and Nelson WJ: Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways. Curr Opin Cell Biol. 9:683–690. 1997. View Article : Google Scholar : PubMed/NCBI

20 

Kikuchi A, Yamamoto H and Kishida S: Multiplicity of the interactions of Wnt proteins and their receptors. Cell Signal. 19:659–671. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Cajanek L, Ribeiro D, Liste I, Parish CL, Bryja V and Arenas E: Wnt/beta-catenin signaling blockade promotes neuronal induction and dopaminergic differentiation in embryonic stem cells. Stem Cells. 27:2917–2927. 2009.PubMed/NCBI

22 

Wang QM, Zhang Y, Yang KM, Zhou HY and Yang HJ: Wnt/beta-catenin signaling pathway is active in pancreatic development of rat embryo. World J Gastroenterol. 12:2615–2619. 2006.PubMed/NCBI

23 

Zhang Y, Li XM, Zhang FK and Wang BE: Activation of canonical Wnt signaling pathway promotes proliferation and self-renewal of rat hepatic oval cell line WB-F344 in vitro. World J Gastroenterol. 14:6673–6680. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Prasad CP, Rath G, Mathur S, Bhatnagar D and Ralhan R: Potent growth suppressive activity of curcumin in human breast cancer cells: Modulation of Wnt/beta-catenin signaling. Chem Biol Interact. 181:263–271. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Larue L and Delmas V: The WNT/Beta-catenin pathway in melanoma. Front Biosci. 11:733–742. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Park JK, Song JH, He TC, Nam SW, Lee JY and Park WS: Overexpression of Wnt-2 in colorectal cancers. Neoplasma. 56:119–123. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Sergio LE and Kalaska JF: Systematic changes in motor cortex cell activity with arm posture during directional isometric force generation. J Neurophysiol. 89:212–228. 2003. View Article : Google Scholar : PubMed/NCBI

28 

Hansson EM, Lendahl U and Chapman G: Notch signaling in development and disease. Semin Cancer Biol. 14:320–328. 2004. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li H, Mo J, Jia G, Liu C, Luan Z and Guan Y: Activation of Wnt signaling inhibits the pro-apoptotic role of Notch in gastric cancer cells. Mol Med Rep 7: 1751-1756, 2013.
APA
Li, H., Mo, J., Jia, G., Liu, C., Luan, Z., & Guan, Y. (2013). Activation of Wnt signaling inhibits the pro-apoptotic role of Notch in gastric cancer cells. Molecular Medicine Reports, 7, 1751-1756. https://doi.org/10.3892/mmr.2013.1412
MLA
Li, H., Mo, J., Jia, G., Liu, C., Luan, Z., Guan, Y."Activation of Wnt signaling inhibits the pro-apoptotic role of Notch in gastric cancer cells". Molecular Medicine Reports 7.6 (2013): 1751-1756.
Chicago
Li, H., Mo, J., Jia, G., Liu, C., Luan, Z., Guan, Y."Activation of Wnt signaling inhibits the pro-apoptotic role of Notch in gastric cancer cells". Molecular Medicine Reports 7, no. 6 (2013): 1751-1756. https://doi.org/10.3892/mmr.2013.1412
Copy and paste a formatted citation
x
Spandidos Publications style
Li H, Mo J, Jia G, Liu C, Luan Z and Guan Y: Activation of Wnt signaling inhibits the pro-apoptotic role of Notch in gastric cancer cells. Mol Med Rep 7: 1751-1756, 2013.
APA
Li, H., Mo, J., Jia, G., Liu, C., Luan, Z., & Guan, Y. (2013). Activation of Wnt signaling inhibits the pro-apoptotic role of Notch in gastric cancer cells. Molecular Medicine Reports, 7, 1751-1756. https://doi.org/10.3892/mmr.2013.1412
MLA
Li, H., Mo, J., Jia, G., Liu, C., Luan, Z., Guan, Y."Activation of Wnt signaling inhibits the pro-apoptotic role of Notch in gastric cancer cells". Molecular Medicine Reports 7.6 (2013): 1751-1756.
Chicago
Li, H., Mo, J., Jia, G., Liu, C., Luan, Z., Guan, Y."Activation of Wnt signaling inhibits the pro-apoptotic role of Notch in gastric cancer cells". Molecular Medicine Reports 7, no. 6 (2013): 1751-1756. https://doi.org/10.3892/mmr.2013.1412
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