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Article

Oxysophocarpine induces anti-nociception and increases the expression of GABAAα1 receptors in mice

  • Authors:
    • Tingting Xu
    • Yuxiang Li
    • Haiyan Wang
    • Yaqiong Xu
    • Lin Ma
    • Tao Sun
    • Hanxiang Ma
    • Jianqiang Yu
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China, Department of Nursing, Changhai Hospital, Second Military Medical University, Shanghai 200433, P.R. China, Department of Pharmacology, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China, Ningxia Key Laboratory of Craniocerebral Diseases, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China, Department of Anesthesiology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China
  • Pages: 1819-1825
    |
    Published online on: April 4, 2013
       https://doi.org/10.3892/mmr.2013.1414
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Abstract

Oxysophocarpine (OSC) is an alkaloid extracted from Siphocampylus verticillatus. The aim of this study was to investigate the anti-nociceptive effects of OSC through systemic and intracerebroventricular administration in mice. Moreover, to evaluate its effectiveness and mechanism of action, this study investigated whether OSC altered the expression of γ-aminobutyric acid type A α1 (GABAAα1) receptors in the central nervous system. Thermal and chemical behavioral models of nociception were used to assess the anti‑nociceptive action of OSC. The warm water tail-flick test, the hot‑plate test, acetic acid-induced abdominal constriction and formalin‑induced pain were used in mice. OSC was administered intraperitoneally (i.p.) or intracerebroventricularly (i.c.v.). Results showed that OSC (80 mg/kg, i.p.) significantly increased the tail withdrawal threshold with a peak effect of 25.46% maximal possible effect (MPE) at 60 min (P﹤0.01). Additionally, OSC (80 mg/kg) increased the positive staining of GABAAα1 receptors in cells. In conclusion, OSC administration is suggested to have anti-nociceptive effects on the central and peripheral nervous systems. The involvement of GABAA receptors in the anti-nociceptive activity of OSC is currently being investigated.
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Copy and paste a formatted citation
Spandidos Publications style
Xu T, Li Y, Wang H, Xu Y, Ma L, Sun T, Ma H and Yu J: Oxysophocarpine induces anti-nociception and increases the expression of GABAAα1 receptors in mice. Mol Med Rep 7: 1819-1825, 2013.
APA
Xu, T., Li, Y., Wang, H., Xu, Y., Ma, L., Sun, T. ... Yu, J. (2013). Oxysophocarpine induces anti-nociception and increases the expression of GABAAα1 receptors in mice. Molecular Medicine Reports, 7, 1819-1825. https://doi.org/10.3892/mmr.2013.1414
MLA
Xu, T., Li, Y., Wang, H., Xu, Y., Ma, L., Sun, T., Ma, H., Yu, J."Oxysophocarpine induces anti-nociception and increases the expression of GABAAα1 receptors in mice". Molecular Medicine Reports 7.6 (2013): 1819-1825.
Chicago
Xu, T., Li, Y., Wang, H., Xu, Y., Ma, L., Sun, T., Ma, H., Yu, J."Oxysophocarpine induces anti-nociception and increases the expression of GABAAα1 receptors in mice". Molecular Medicine Reports 7, no. 6 (2013): 1819-1825. https://doi.org/10.3892/mmr.2013.1414
Copy and paste a formatted citation
x
Spandidos Publications style
Xu T, Li Y, Wang H, Xu Y, Ma L, Sun T, Ma H and Yu J: Oxysophocarpine induces anti-nociception and increases the expression of GABAAα1 receptors in mice. Mol Med Rep 7: 1819-1825, 2013.
APA
Xu, T., Li, Y., Wang, H., Xu, Y., Ma, L., Sun, T. ... Yu, J. (2013). Oxysophocarpine induces anti-nociception and increases the expression of GABAAα1 receptors in mice. Molecular Medicine Reports, 7, 1819-1825. https://doi.org/10.3892/mmr.2013.1414
MLA
Xu, T., Li, Y., Wang, H., Xu, Y., Ma, L., Sun, T., Ma, H., Yu, J."Oxysophocarpine induces anti-nociception and increases the expression of GABAAα1 receptors in mice". Molecular Medicine Reports 7.6 (2013): 1819-1825.
Chicago
Xu, T., Li, Y., Wang, H., Xu, Y., Ma, L., Sun, T., Ma, H., Yu, J."Oxysophocarpine induces anti-nociception and increases the expression of GABAAα1 receptors in mice". Molecular Medicine Reports 7, no. 6 (2013): 1819-1825. https://doi.org/10.3892/mmr.2013.1414
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