Pain‑relieving effect of a compound isolated from white peony root oral liquid on acute radiation‑induced esophagitis

Wang,Zhiyu; Shen,Li; Li,Xing; Shu,Xin; Shan,Baoen; Zhang,Li; Gong,Yanjun; Dong,Zhiming

doi:10.3892/mmr.2013.1427

June 2013 Volume 7 Issue 6

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June 2013 Volume 7 Issue 6

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Article

Pain‑relieving effect of a compound isolated from white peony root oral liquid on acute radiation‑induced esophagitis

Authors:
- Zhiyu Wang
- Li Shen
- Xing Li
- Xin Shu
- Baoen Shan
- Li Zhang
- Yanjun Gong
- Zhiming Dong
View Affiliations / Copyright

Affiliations: Department of Biotherapy, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China, Department of Traditional Chinese Medicine, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, P.R. China, Department of Medical Oncology, The General Hospital of Chinese Armed Police Force, Haidian, Beijing 100039, P.R. China, Centre of HMO Administrator of Shijiazhuang, Shijiazhuang, Hebei 050031, P.R. China
Pages: 1950-1954
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Published online on: April 11, 2013

https://doi.org/10.3892/mmr.2013.1427
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Abstract

Acute radiation‑induced esophagitis (ARIE) is a common complication of radiotherapy. The aim of this study was to clarify the molecular mechanism of pain relief by the compound of white peony root oral liquid (cWPROL) in ARIE. An animal model of ARIE was established and either cWPROL or a mixture of lidocaine, dexamethasone and gentamycin (mLDG) was administered. We indirectly observed rat symptoms of pain by recording the weight of food and the volume of water consumed by the rats, along with changes in body weight. Additionally, the expression levels of substance P (SP) in the esophageal tissues were detected by immunohistochemistry. It was demonstrated that cWPROL was able to release the pain of ARIE by decreasing the expression of SP; this may be one of the molecular mechanisms via which cWPROL induces pain relief.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Pain‑relieving effect of a compound isolated from white peony root oral liquid on acute radiation‑induced esophagitis

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