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Article

BDNF protects retinal neurons from hyperglycemia through the TrkB/ERK/MAPK pathway

  • Authors:
    • Yu Liu
    • Lijian Tao
    • Xiao Fu
    • Yingchun Zhao
    • Xueliang Xu
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P.R. China, Department of Nephrology, Xiangya Hospital, Changsha, Hunan 410008, P.R. China, Department of Biostatistics and Bioinformatics, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA, Department of Ophthalmology, Xiangya Hospital, Changsha, Hunan 410008, P.R. China
  • Pages: 1773-1778
    |
    Published online on: April 18, 2013
       https://doi.org/10.3892/mmr.2013.1433
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Abstract

Diabetic retinopathy (DR) is one of the most common diabetic eye diseases and a leading cause of blindness. It is characterized by changes in the blood vessels of the retina. The pathogenesis of DR is complex and to date, the precise mechanisms involved remain unclear. Previous studies have reported that DR is associated with neurodegeneration and that apoptosis may occur in diabetic retinas. In the present study, retinal neurons under conditions of hyperglycemia were used as a model to study apoptosis in diabetic retinas. Retinal neurons exposed to hyperglycemia exhibited high levels of apoptosis. Brain‑derived neurotrophic factor (BDNF), a member of the neurotrophin family, was effective in protecting retinal neurons from hyperglycemia in vitro. BDNF promoted neuronal cell survival in a concentration‑dependent manner. In addition, BDNF was demonstrated to promote the expression of tropomyosin‑related kinase B (TrkB) and elevate the phosphorylation levels of TrkB and ERK in retinal neurons exposed to hyperglycemia. The results of the present study demonstrated that BDNF may protect retinal neurons from hyperglycemia via the TrkB/ERK/MAPK pathway and provides novel insights into the pathogenesis of DR.
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Copy and paste a formatted citation
Spandidos Publications style
Liu Y, Tao L, Fu X, Zhao Y and Xu X: BDNF protects retinal neurons from hyperglycemia through the TrkB/ERK/MAPK pathway. Mol Med Rep 7: 1773-1778, 2013.
APA
Liu, Y., Tao, L., Fu, X., Zhao, Y., & Xu, X. (2013). BDNF protects retinal neurons from hyperglycemia through the TrkB/ERK/MAPK pathway. Molecular Medicine Reports, 7, 1773-1778. https://doi.org/10.3892/mmr.2013.1433
MLA
Liu, Y., Tao, L., Fu, X., Zhao, Y., Xu, X."BDNF protects retinal neurons from hyperglycemia through the TrkB/ERK/MAPK pathway". Molecular Medicine Reports 7.6 (2013): 1773-1778.
Chicago
Liu, Y., Tao, L., Fu, X., Zhao, Y., Xu, X."BDNF protects retinal neurons from hyperglycemia through the TrkB/ERK/MAPK pathway". Molecular Medicine Reports 7, no. 6 (2013): 1773-1778. https://doi.org/10.3892/mmr.2013.1433
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Y, Tao L, Fu X, Zhao Y and Xu X: BDNF protects retinal neurons from hyperglycemia through the TrkB/ERK/MAPK pathway. Mol Med Rep 7: 1773-1778, 2013.
APA
Liu, Y., Tao, L., Fu, X., Zhao, Y., & Xu, X. (2013). BDNF protects retinal neurons from hyperglycemia through the TrkB/ERK/MAPK pathway. Molecular Medicine Reports, 7, 1773-1778. https://doi.org/10.3892/mmr.2013.1433
MLA
Liu, Y., Tao, L., Fu, X., Zhao, Y., Xu, X."BDNF protects retinal neurons from hyperglycemia through the TrkB/ERK/MAPK pathway". Molecular Medicine Reports 7.6 (2013): 1773-1778.
Chicago
Liu, Y., Tao, L., Fu, X., Zhao, Y., Xu, X."BDNF protects retinal neurons from hyperglycemia through the TrkB/ERK/MAPK pathway". Molecular Medicine Reports 7, no. 6 (2013): 1773-1778. https://doi.org/10.3892/mmr.2013.1433
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