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Article

Ser 15 of WEE1B is a potential PKA phosphorylation target in G2/M transition in one-cell stage mouse embryos

  • Authors:
    • Chao Liu
    • Yanchun Liu
    • Yang Liu
    • Didi Wu
    • Zhidong Luan
    • Enhua Wang
    • Bingzhi Yu
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry and Molecular Biology, China Medical University, Shenyang, Liaoning, P.R. China, Department of Developmental Biology, Liaoning Medical University, Jinzhou, Liaoning, P.R. China, Institute of Pathology and Pathopysiology, China Medical University, Shenyang, Liaoning, P.R. China
  • Pages: 1929-1937
    |
    Published online on: April 24, 2013
       https://doi.org/10.3892/mmr.2013.1437
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Abstract

The WEE1 kinase family has been shown to be the major kinase family responsible for phosphorylating Tyr 15 on cyclin-dependent kinase 1 (CDK1). WEE1 homolog 2 (WEE2, also known as WEE1B) was first identified in Xenopus laevis and more recently in humans and mice, and is responsible for phosphorylating the CDK1 inhibitory site and maintaining meiotic arrest in oocytes. However, the mechanism by which WEE1B is regulated in one-cell stage mouse embryos remains to be elucidated. In the present study, we examined the role of WEE1B-Ser 15 in G2/M transition of one-cell stage mouse embryos. WEE1B-Ser 15 was phosphorylated during the G1 and S phases, whereas Ser 15 was dephosphorylated during G2 and M phases in vivo. Overexpression of the phosphor-mimic Wee1B-S15D mutant delayed the re-entry of embryos into mitosis more efficiently than Wee1B-wild type (Wee1B-WT) by direct phosphorylation of CDK1-Tyr 15. The results of the present study suggested that WEE1B acts as a direct downstream substrate of protein kinase A (PKA) and that Ser 15 of WEE1B is a potential PKA phosphorylation target in the G2/M transition of mouse embryos. In addition, WEE1B inhibits mitosis by negatively regulating M phase promoting factor activity in one-cell stage mouse embryos.
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1 

Nigg EA: Mitotic kinases as regulators of cell division and its checkpoints. Nat Rev Mol Cell Biol. 2:21–32. 2001. View Article : Google Scholar : PubMed/NCBI

2 

Nurse P: Universal control mechanism regulating onset of M-phase. Nature. 344:503–508. 1990. View Article : Google Scholar : PubMed/NCBI

3 

Coleman TR and Dunphy WG: Cdc2 regulatory factors. Curr Opin Cell Biol. 6:877–882. 1994. View Article : Google Scholar : PubMed/NCBI

4 

Lew DJ and Kornbluth S: Regulatory roles of cyclin dependent kinase phosphorylation in cell cycle control. Curr Opin Cell Biol. 8:795–804. 1996. View Article : Google Scholar : PubMed/NCBI

5 

Nakajima H, Yonemura S, Murata M, Nakamura N, Piwnica-Worms H and Nishida E: Myt1 protein kinase is essential for Golgi and ER assembly during mitotic exit. J Cell Biol. 181:89–103. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Mueller PR, Coleman TR, Kumagai A and Dunphy WG: Myt1: a membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15. Science. 270:86–90. 1995. View Article : Google Scholar : PubMed/NCBI

7 

Booher RN, Deshaies RJ and Kirschner MW: Properties of Saccharomyces cerevisiae wee1 and its differential regulation of p34CDC28 in response to G1 and G2 cyclins. EMBO J. 12:3417–3426. 1993.

8 

McGowan CH and Russell P: Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15. EMBO J. 12:75–85. 1993.PubMed/NCBI

9 

McGowan CH and Russell P: Cell cycle regulation of human WEE1. EMBO J. 14:2166–2175. 1995.PubMed/NCBI

10 

Mueller PR, Coleman TR and Dunphy WG: Cell cycle regulation of a Xenopus Wee1-like kinase. Mol Biol Cell. 6:119–134. 1995. View Article : Google Scholar

11 

Kornbluth S, Sebastian B, Hunter T and Newport J: Membrane localization of the kinase which phosphorylates p34cdc2 on threonine 14. Mol Biol Cell. 5:273–282. 1994. View Article : Google Scholar : PubMed/NCBI

12 

Booher RN, Holman PS and Fattaey A: Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity. J Biol Chem. 272:22300–22306. 1997. View Article : Google Scholar : PubMed/NCBI

13 

Liu F, Stanton JJ, Wu Z and Piwnica-Worms H: The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex. Mol Cell Biol. 17:571–583. 1997.PubMed/NCBI

14 

Liu F, Rothblum-Oviatt C, Ryan CE and Piwnica-Worms H: Overproduction of human Myt1 kinase induces a G2 cell cycle delay by interfering with the intracellular trafficking of Cdc2-cyclin B1 complexes. Mol Cell Biol. 19:5113–5123. 1999.PubMed/NCBI

15 

Wells NJ, Watanabe N, Tokusumi T, Jiang W, Verdecia MA and Hunter T: The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M progression. J Cell Sci. 112(Pt 19): 3361–3371. 1999.PubMed/NCBI

16 

Hanna CB, Yao S, Patta MC, Jensen JT and Wu X: WEE2 is an oocyte-specific meiosis inhibitor in rhesus macaque monkeys. Biol Reprod. 82:1190–1197. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Shimaoka T, Nishimura T, Kano K and Naito K: Critical effect of pigWee1B on the regulation of meiotic resumption in porcine immature oocytes. Cell Cycle. 8:2375–2384. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Nakanishi M, Ando H, Watanabe N, et al: Identification and characterization of human Wee1B, a new member of the Wee1 family of Cdk-inhibitory kinases. Genes Cells. 5:839–847. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Nishimura T, Shimaoka T, Kano K and Naito K: Insufficient amount of Cdc2 and continuous activation of Wee1 B are the cause of meiotic failure in porcine growing oocytes. J Reprod Dev. 55:553–557. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Han SJ and Conti M: New pathways from PKA to the Cdc2/cyclin B complex in oocytes: Wee1B as a potential PKA substrate. Cell Cycle. 5:227–231. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Han SJ, Chen R, Paronetto MP and Conti M: Wee1B is an oocyte-specific kinase involved in the control of meiotic arrest in the mouse. Curr Biol. 15:1670–1676. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Mueller PR and Leise WF 3rd: Measurement of Wee kinase activity. Methods Mol Biol. 296:299–328. 2005.PubMed/NCBI

23 

Islam MS, Kawase O, Hase S, Hoshi M and Matsumoto M: PKA activation in concert with ARIS and asterosap induces the acrosome reaction in starfish. Zygote. 14:329–340. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Wang J and Liu XJ: Progesterone inhibits protein kinase A (PKA) in Xenopus oocytes: demonstration of endogenous PKA activities using an expressed substrate. J Cell Sci. 117:5107–5116. 2004.PubMed/NCBI

25 

Pirino G, Wescott MP and Donovan PJ: Protein kinase A regulates resumption of meiosis by phosphorylation of Cdc25B in mammalian oocytes. Cell Cycle. 8:665–670. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Kovo M, Kandli-Cohen M, Ben-Haim M, Galiani D, Carr DW and Dekel N: An active protein kinase A (PKA) is involved in meiotic arrest of rat growing oocytes. Reproduction. 132:33–43. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Xiao J, Liu C, Hou J, et al: Ser149 is another potential PKA phosphorylation target of Cdc25B in G2/M transition of fertilized mouse eggs. J Biol Chem. 286:10356–10366. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Schultz R: PKA and CDC25B: at last connected. Cell Cycle. 8:516–517. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Zhang Y, Zhang Z, Xu XY, et al: Protein kinase A modulates Cdc25B activity during meiotic resumption of mouse oocytes. Dev Dyn. 237:3777–3786. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Okamoto K and Sagata N: Mechanism for inactivation of the mitotic inhibitory kinase Wee1 at M phase. Proc Natl Acad Sci USA. 104:3753–3758. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Burrows AE, Sceurman BK, Kosinski ME, et al: The C. elegans Myt1 ortholog is required for the proper timing of oocyte maturation. Development. 133:697–709. 2006.

32 

Maller JL, Butcher FR and Krebs EG: Early effect of progesterone on levels of cyclic adenosine 3′:5′-monophosphate in Xenopus oocytes. J Biol Chem. 254:579–582. 1979.

33 

Conti M, Andersen CB, Richard FJ, Shitsukawa K and Tsafriri A: Role of cyclic nucleotide phosphodiesterases in resumption of meiosis. Mol Cell Endocrinol. 145:9–14. 1998.PubMed/NCBI

34 

Conti M, Andersen CB, Richard F, et al: Role of cyclic nucleotide signaling in oocyte maturation. Mol Cell Endocrinol. 187:153–159. 2002. View Article : Google Scholar : PubMed/NCBI

35 

Dekel N: Protein phosphorylation/dephosphorylation in the meiotic cell cycle of mammalian oocytes. Rev Reprod. 1:82–88. 1996. View Article : Google Scholar : PubMed/NCBI

36 

Okamoto K, Nakajo N and Sagata N: The existence of two distinct Wee1 isoforms in Xenopus: implications for the developmental regulation of the cell cycle. EMBO J. 21:2472–2484. 2002. View Article : Google Scholar : PubMed/NCBI

37 

Parker LL and Piwnica-Worms H: Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase. Science. 257:1955–1957. 1992. View Article : Google Scholar : PubMed/NCBI

38 

Hogan B, Beddington R, Constantini F and Lacy E: Manipulating the mouse embryo: a laboratory manual. Cold Harbor Laboratory Press; New York: 1986

39 

Zhang Z, Su WH, Feng C, et al: Polo-like kinase 1 may regulate G2/M transition of mouse fertilized eggs by means of inhibiting the phosphorylation of Tyr 15 of Cdc2. Mol Reprod Dev. 74:1247–1254. 2007. View Article : Google Scholar : PubMed/NCBI

40 

Cui C, Zhao H, Zhang Z, et al: CDC25B acts as a potential target of PRKACA in fertilized mouse eggs. Biol Reprod. 79:991–998. 2008. View Article : Google Scholar : PubMed/NCBI

41 

Gallicano GI, McGaughey RW and Capco DG: Activation of protein kinase C after fertilization is required for remodeling the mouse egg into the zygote. Mol Reprod Dev. 46:587–601. 1997. View Article : Google Scholar : PubMed/NCBI

42 

Xu XY, Zhang Z, Su WH, et al: Involvement of the p110 alpha isoform of PI3K in early development of mouse embryos. Mol Reprod Dev. 76:389–398. 2009. View Article : Google Scholar : PubMed/NCBI

43 

Vitolo OV, Sant'Angelo A, Costanzo V, Battaglia F, Arancio O and Shelanski M: Amyloid β-peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling. Proc Natl Acad Sci USA. 99:13217–13221. 2002.

44 

Yamada T, Matsuda K and Uchiyama M: Atrial natriuretic peptide and cGMP activate sodium transport through PKA-dependent pathway in the urinary bladder of the Japanese tree frog. J Comp Physiol B. 176:203–212. 2006. View Article : Google Scholar : PubMed/NCBI

45 

Shimaoka T, Nishimura T, Kano K and Naito K: Analyses of the regulatory mechanism of porcine WEE1B: the phosphorylation sites of porcine WEE1B and mouse WEE1B are different. J Reprod Dev. 57:223–228. 2010. View Article : Google Scholar : PubMed/NCBI

46 

Yu B, Wang Y, Liu Y, et al: Protein kinase A regulates cell cycle progression of mouse fertilized eggs by means of MPF. Dev Dyn. 232:98–105. 2005. View Article : Google Scholar : PubMed/NCBI

47 

Oh JS, Han SJ and Conti M: Wee1B, Myt1, and Cdc25 function in distinct compartments of the mouse oocyte to control meiotic resumption. J Cell Biol. 188:199–207. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu C, Liu Y, Liu Y, Wu D, Luan Z, Wang E and Yu B: Ser 15 of WEE1B is a potential PKA phosphorylation target in G2/M transition in one-cell stage mouse embryos. Mol Med Rep 7: 1929-1937, 2013.
APA
Liu, C., Liu, Y., Liu, Y., Wu, D., Luan, Z., Wang, E., & Yu, B. (2013). Ser 15 of WEE1B is a potential PKA phosphorylation target in G2/M transition in one-cell stage mouse embryos. Molecular Medicine Reports, 7, 1929-1937. https://doi.org/10.3892/mmr.2013.1437
MLA
Liu, C., Liu, Y., Liu, Y., Wu, D., Luan, Z., Wang, E., Yu, B."Ser 15 of WEE1B is a potential PKA phosphorylation target in G2/M transition in one-cell stage mouse embryos". Molecular Medicine Reports 7.6 (2013): 1929-1937.
Chicago
Liu, C., Liu, Y., Liu, Y., Wu, D., Luan, Z., Wang, E., Yu, B."Ser 15 of WEE1B is a potential PKA phosphorylation target in G2/M transition in one-cell stage mouse embryos". Molecular Medicine Reports 7, no. 6 (2013): 1929-1937. https://doi.org/10.3892/mmr.2013.1437
Copy and paste a formatted citation
x
Spandidos Publications style
Liu C, Liu Y, Liu Y, Wu D, Luan Z, Wang E and Yu B: Ser 15 of WEE1B is a potential PKA phosphorylation target in G2/M transition in one-cell stage mouse embryos. Mol Med Rep 7: 1929-1937, 2013.
APA
Liu, C., Liu, Y., Liu, Y., Wu, D., Luan, Z., Wang, E., & Yu, B. (2013). Ser 15 of WEE1B is a potential PKA phosphorylation target in G2/M transition in one-cell stage mouse embryos. Molecular Medicine Reports, 7, 1929-1937. https://doi.org/10.3892/mmr.2013.1437
MLA
Liu, C., Liu, Y., Liu, Y., Wu, D., Luan, Z., Wang, E., Yu, B."Ser 15 of WEE1B is a potential PKA phosphorylation target in G2/M transition in one-cell stage mouse embryos". Molecular Medicine Reports 7.6 (2013): 1929-1937.
Chicago
Liu, C., Liu, Y., Liu, Y., Wu, D., Luan, Z., Wang, E., Yu, B."Ser 15 of WEE1B is a potential PKA phosphorylation target in G2/M transition in one-cell stage mouse embryos". Molecular Medicine Reports 7, no. 6 (2013): 1929-1937. https://doi.org/10.3892/mmr.2013.1437
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