Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
July 2013 Volume 8 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July 2013 Volume 8 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Positive correlation between variants of lipid metabolism‑related genes and coronary heart disease

  • Authors:
    • Li-Na Zhang
    • Pan-Pan Liu
    • Jianqing Zhou
    • R. Stephanie Huang
    • Fang Yuan
    • Li-Juan Fei
    • Yi Huang
    • Limin Xu
    • Ling-Mei Hao
    • Xu-Jun Qiu
    • Yanping Le
    • Xi Yang
    • Weifeng Xu
    • Xiaoyan Huang
    • Meng Ye
    • Jiangfang Lian
    • Shiwei Duan
  • View Affiliations / Copyright

    Affiliations: School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China, Ningbo Medical Center, Lihuili Hospital, Ningbo University, Ningbo, Zhejiang 315041, P.R. China, Department of Medicine, University of Chicago, Chicago, IL 60637, USA, Clinical Laboratory, The Seventh Hospital of Ningbo, Ningbo, Zhejiang 315202, P.R. China, Department of Cardiology, The Affiliated Hospital, Ningbo University, Ningbo, Zhejiang 315211, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 260-266
    |
    Published online on: May 2, 2013
       https://doi.org/10.3892/mmr.2013.1454
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Four gene variants related to lipid metabolism (including the rs562338 and rs503662 variants of the APOB gene, the rs7767084 variant of the LPA gene and the rs2246942 variant of the LIPA gene) have been shown to be associated with coronary heart disease (CHD). The aim of the present study was to assess their association with CHD in the Han Chinese population and to assess the contribution of these gene variants to CHD. Using the standardized coronary angiography method, we enrolled 290 CHD patients and 193 non-CHD patients as non-CHD controls from Lihuili Hospital (Ningbo, China). In addition, we recruited 330 unrelated healthy volunteers as healthy controls from the Xi Men Community (Ningbo, China). Our results demonstrated that the rs503662 and rs562338 variants of the APOB gene were extremely rare in the Han Chinese population (minor allele frequency <1%). Genotype rs2246942-GG of the LIPA gene was associated with an increased risk of CHD [CHD cases versus healthy controls: P=0.04; odds ratio (OR)=1.63; 95% confidence interval (CI)=1.02-2.60). Genotype rs7767084-CC of the LPA gene was identified as a protective factor against CHD in females (CHD cases versus non-CHD controls: P=0.04, OR=0.21; CHD cases versus healthy controls: P=0.02, OR=0.21). The results of our meta-analysis indicated that rs7767084 was not associated with a high risk of CHD (P=0.83; combined OR=0.93; 95% CI=0.47-1.85). In the present study, two single nucleotide polymorphisms (SNPs) of genes involved in lipid metabolism (rs2246942 and rs7767084) were identified to be significantly associated with CHD in the Han Chinese population. Specifically, rs2246942-GG of the LIPA gene was a risk factor for CHD, while rs7767084-CC of the LPA gene was a protective factor against CHD in females. However, our meta-analysis indicated that rs7767084 is not associated with a higher risk of CHD.
View Figures

Figure 1

Figure 2

View References

1 

Yu J, Huang J, Liang Y, et al: Lack of association between apolipoprotein C3 gene polymorphisms and risk of coronary heart disease in a Han population in East China. Lipids Health Dis. 10:2002011. View Article : Google Scholar : PubMed/NCBI

2 

Sandhu MS, Waterworth DM, Debenham SL, et al: LDL-cholesterol concentrations: a genome-wide association study. Lancet. 371:483–491. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Baigent C, Keech A, Kearney PM, et al: Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins. Lancet. 366:1267–1278. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Willer CJ, Sanna S, Jackson AU, et al: Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet. 40:161–169. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Lettre G, Palmer CD, Young T, et al: Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. PLoS Genet. 7:e10013002011. View Article : Google Scholar : PubMed/NCBI

6 

St-Pierre AC, Cantin B, Dagenais GR, et al: Apolipoprotein-B, low-density lipoprotein cholesterol, and the long-term risk of coronary heart disease in men. Am J Cardiol. 97:997–1001. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Moss AJ, Goldstein RE, Marder VJ, et al: Thrombogenic factors and recurrent coronary events. Circulation. 99:2517–2522. 1999. View Article : Google Scholar : PubMed/NCBI

8 

Talmud PJ, Hawe E, Miller GJ and Humphries SE: Nonfasting apolipoprotein B and triglyceride levels as a useful predictor of coronary heart disease risk in middle-aged UK men. Arterioscler Thromb Vasc Biol. 22:1918–1923. 2002. View Article : Google Scholar : PubMed/NCBI

9 

Walldius G and Jungner I: The apoB/apoA-I ratio: a strong, new risk factor for cardiovascular disease and a target for lipid-lowering therapy - a review of the evidence. J Intern Med. 259:493–519. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Kamstrup PR, Tybjærg-Hansen A and Nordestgaard BG: Genetic evidence that lipoprotein(a) associates with atherosclerotic stenosis rather than venous thrombosis. Arterioscler Thromb Vasc Biol. 32:1732–1741. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Szilágyi S, Péter A, Magyar MT, et al: Recurrent arterial thrombosis associated with the antithrombin basel variant and elevated lipoprotein(a) plasma level in an adolescent patient. J Pediatr Hematol Oncol. 34:276–279. 2012.PubMed/NCBI

12 

Terres W, Tatsis E, Pfalzer B, et al: Rapid angiographic progression of coronary artery disease in patients with elevated lipoprotein(a). Circulation. 91:948–950. 1995. View Article : Google Scholar : PubMed/NCBI

13 

Deshmukh HA, Colhoun HM, Johnson T, et al: Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importance of Lp(a). J Lipid Res. 53:1000–1011. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Teslovich TM, Musunuru K, Smith AV, et al: Biological, clinical and population relevance of 95 loci for blood lipids. Nature. 466:707–713. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Trégouët DA, König IR, Erdmann J, et al: Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease. Nat Genet. 41:283–285. 2009.PubMed/NCBI

16 

Qi L, Ma J, Qi Q, et al: Genetic risk score and risk of myocardial infarction in Hispanics. Circulation. 123:374–380. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Butterworth AS, Braund PS, Farrall M, et al; IBC 50K CAD Consortium. Large-scale gene-centric analysis identifies novel variants for coronary artery disease. PLoS Genet. 7:e10022602011. View Article : Google Scholar : PubMed/NCBI

18 

Peden JF, Hopewell JC, Saleheen D, et al: Coronary Artery Disease (C4D) Genetics Consortium: A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. Nat Genet. 43:339–344. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Higgs ZC, Macafee DA, Braithwaite BD and Maxwell-Armstrong CA: The Seldinger technique: 50 years on. Lancet. 366:1407–1409. 2005.PubMed/NCBI

20 

Reilly MP, Li M, He J, et al: Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies. Lancet. 377:383–392. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Gabriel S, Ziaugra L and Tabbaa D: SNP genotyping using the Sequenom MassARRAY iPLEX platform. Curr Protoc Hum Genet. Chapter 2(Unit 2): 122009.PubMed/NCBI

22 

Higgins JP, Thompson SG, Deeks JJ and Altman DG: Measuring inconsistency in meta-analyses. BMJ. 327:557–560. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Egger M, Davey Smith G, Schneider M and Minder C: Bias in meta-analysis detected by a simple, graphical test. BMJ. 315:629–634. 1997. View Article : Google Scholar : PubMed/NCBI

24 

Excoffier L and Lischer HE: Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows. Mol Ecol Resour. 10:564–567. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Dupont WD and Plummer WD Jr: Power and sample size calculations. A review and computer program. Control Clin Trials. 11:116–128. 1990. View Article : Google Scholar : PubMed/NCBI

26 

Emslie C: Women, men and coronary heart disease: a review of the qualitative literature. J Adv Nurs. 51:382–395. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Robinson JG, Wang S and Jacobson TA: Meta-analysis of comparison of effectiveness of lowering apolipoprotein B versus low-density lipoprotein cholesterol and nonhigh-density lipoprotein cholesterol for cardiovascular risk reduction in randomized trials. Am J Cardiol. 110:1468–1476. 2012. View Article : Google Scholar

28 

Li S, Lei ZW, Chen Z, et al: Relationship between apolipoprotein E and apolipoprotein B polymorphisms in youths with coronary heart disease. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 20:241–243. 2003.(In Chinese).

29 

Huang G, Zhong H, Re HM, et al: Coalition of DNA polymorphisms of ApoB and ApoAI genes is related with coronary artery disease in Kazaks. J Geriatr Cardiol. 9:33–37. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Boffa MB, Marcovina SM and Koschinsky ML: Lipoprotein(a) as a risk factor for atherosclerosis and thrombosis: mechanistic insights from animal models. Clin Biochem. 37:333–343. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Kamstrup PR: Lipoprotein(a) and ischemic heart disease - a causal association? A review. Atherosclerosis. 211:15–23. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Rath M, Niendorf A, Reblin T, et al: Detection and quantification of lipoprotein(a) in the arterial wall of 107 coronary bypass patients. Arteriosclerosis. 9:579–592. 1989.PubMed/NCBI

33 

Kiechl S and Willeit J: The mysteries of lipoprotein(a) and cardiovascular disease revisited. J Am Coll Cardiol. 55:2168–2170. 2010.PubMed/NCBI

34 

Clarke R, Peden JF, Hopewell JC, et al; PROCARDIS Consortium. Genetic variants associated with Lp(a) lipoprotein level and coronary disease. N Engl J Med. 361:2518–2528. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Chasman DI, Shiffman D, Zee RY, et al: Polymorphism in the apolipoprotein(a) gene, plasma lipoprotein(a), cardiovascular disease, and low-dose aspirin therapy. Atherosclerosis. 203:371–376. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Luke MM, Kane JP, Liu DM, et al: A polymorphism in the protease-like domain of apolipoprotein(a) is associated with severe coronary artery disease. Arterioscler Thromb Vasc Biol. 27:2030–2036. 2007. View Article : Google Scholar : PubMed/NCBI

37 

Schunkert H, König IR, Kathiresan S, et al: Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet. 43:333–338. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Anderson RA and Sando GN: Cloning and expression of cDNA encoding human lysosomal acid lipase/cholesteryl ester hydrolase. Similarities to gastric and lingual lipases. J Biol Chem. 266:22479–22484. 1991.PubMed/NCBI

39 

Anderson RA, Rao N, Byrum RS, et al: In situ localization of the genetic locus encoding the lysosomal acid lipase/cholesteryl esterase (LIPA) deficient in Wolman disease to chromosome 10q23.2-q23.3. Genomics. 15:245–247. 1993. View Article : Google Scholar : PubMed/NCBI

40 

Zschenker O, Illies T and Ameis D: Overexpression of lysosomal acid lipase and other proteins in atherosclerosis. J Biochem. 140:23–38. 2006. View Article : Google Scholar : PubMed/NCBI

41 

Klima H, Ullrich K, Aslanidis C, et al: A splice junction mutation causes deletion of a 72-base exon from the mRNA for lysosomal acid lipase in a patient with cholesteryl ester storage disease. J Clin Invest. 92:2713–2718. 1993. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang L, Liu P, Zhou J, Huang RS, Yuan F, Fei L, Huang Y, Xu L, Hao L, Qiu X, Qiu X, et al: Positive correlation between variants of lipid metabolism‑related genes and coronary heart disease. Mol Med Rep 8: 260-266, 2013.
APA
Zhang, L., Liu, P., Zhou, J., Huang, R.S., Yuan, F., Fei, L. ... Duan, S. (2013). Positive correlation between variants of lipid metabolism‑related genes and coronary heart disease. Molecular Medicine Reports, 8, 260-266. https://doi.org/10.3892/mmr.2013.1454
MLA
Zhang, L., Liu, P., Zhou, J., Huang, R. S., Yuan, F., Fei, L., Huang, Y., Xu, L., Hao, L., Qiu, X., Le, Y., Yang, X., Xu, W., Huang, X., Ye, M., Lian, J., Duan, S."Positive correlation between variants of lipid metabolism‑related genes and coronary heart disease". Molecular Medicine Reports 8.1 (2013): 260-266.
Chicago
Zhang, L., Liu, P., Zhou, J., Huang, R. S., Yuan, F., Fei, L., Huang, Y., Xu, L., Hao, L., Qiu, X., Le, Y., Yang, X., Xu, W., Huang, X., Ye, M., Lian, J., Duan, S."Positive correlation between variants of lipid metabolism‑related genes and coronary heart disease". Molecular Medicine Reports 8, no. 1 (2013): 260-266. https://doi.org/10.3892/mmr.2013.1454
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang L, Liu P, Zhou J, Huang RS, Yuan F, Fei L, Huang Y, Xu L, Hao L, Qiu X, Qiu X, et al: Positive correlation between variants of lipid metabolism‑related genes and coronary heart disease. Mol Med Rep 8: 260-266, 2013.
APA
Zhang, L., Liu, P., Zhou, J., Huang, R.S., Yuan, F., Fei, L. ... Duan, S. (2013). Positive correlation between variants of lipid metabolism‑related genes and coronary heart disease. Molecular Medicine Reports, 8, 260-266. https://doi.org/10.3892/mmr.2013.1454
MLA
Zhang, L., Liu, P., Zhou, J., Huang, R. S., Yuan, F., Fei, L., Huang, Y., Xu, L., Hao, L., Qiu, X., Le, Y., Yang, X., Xu, W., Huang, X., Ye, M., Lian, J., Duan, S."Positive correlation between variants of lipid metabolism‑related genes and coronary heart disease". Molecular Medicine Reports 8.1 (2013): 260-266.
Chicago
Zhang, L., Liu, P., Zhou, J., Huang, R. S., Yuan, F., Fei, L., Huang, Y., Xu, L., Hao, L., Qiu, X., Le, Y., Yang, X., Xu, W., Huang, X., Ye, M., Lian, J., Duan, S."Positive correlation between variants of lipid metabolism‑related genes and coronary heart disease". Molecular Medicine Reports 8, no. 1 (2013): 260-266. https://doi.org/10.3892/mmr.2013.1454
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team