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Article

Prevalence and management of hypertension in patients with acute coronary syndrome vary with gender: Observations from the Chinese registry of acute coronary events (CRACE)

  • Authors:
    • Yun Lin
    • Weiqi Pan
    • Shangqiu Ning
    • Xiantao Song
    • Zening Jin
    • Shuzheng Lv
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing 100029, P.R. China
  • Pages: 173-177
    |
    Published online on: May 8, 2013
       https://doi.org/10.3892/mmr.2013.1461
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Abstract

Hypertension affects one billion people worldwide and is an independent risk factor for death after acute coronary syndrome (ACS). The aim of this study was to examine the prevalence and medical treatment of hypertension among 1,301 ACS patients enrolled into the Chinese registry of acute coronary events (CRACE) trial. Analyses were performed by gender, with both genders combined and according to international practice. Multivariable models identified factors associated with use of different classes of antihypertensive medication, and examined the correlation between hypertension and gender with mortality. The use of angiotensin‑converting enzyme inhibitors (ACEI), β-blockers, calcium channel blockers (CCBs) and diuretics increased in both genders during management of presenting ACS. Hypertensive men were more likely to have been receiving β-blockers when they were discharged (77.2%) than women (69.2%). Hypertensive women were more likely to have received diuretics when they were discharged (28.4%) than men (22%). ACEI use increased by ~60% (absolute increase) in both women and men as a result of ACS treatment, but remained similar between the genders, and the same phenomenon was observed in the use of CCBs. Moreover, hypertensive women were less likely to receive evidence‑based medication to treat their acute coronary event than men (for women and men, respectively: β-blocker, 69.2 vs. 77.2%; ACEI, 85.8 vs. 87.5%). Hypertension is more prevalent in women than in men with ACS, and its medical management varies with gender, but it has a similar association with mortality in both genders. Opportunities exist to improve medical therapy and outcomes for women with hypertension.
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1 

World Health Organization. The world health report 2002: reducing risks, promoting healthy life. http://www.who.int/whr/2002. Accessed January 2005

2 

Yusuf S, Hawken S, Ounpuu S, et al: Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet. 364:937–952. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Lee KL, Woodlief LH, Topol EJ, et al: Predictors of 30-day mortality in the era of reperfusion for acute myocardial infarction. Results from an international trial of 41,021 patients GUSTO-I Investigators. Circulation. 91:1659–1668. 1995. View Article : Google Scholar : PubMed/NCBI

4 

Newby LK, Bhapkar MV, White HD, et al: Predictors of 90-day outcome in patients stabilized after acute coronary syndromes. Eur Heart J. 24:172–181. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Antman EM, Cohen M, Bernink PJ, et al: The TIMI risk score for unstable angina/non-ST elevation MI: a method for prognostication and therapeutic decision making. JAMA. 284:835–842. 2000. View Article : Google Scholar : PubMed/NCBI

6 

Pepine CJ, Handberg EM, Cooper-DeHoff RM, et al: A calcium antagonist vs a non-calcium antagonist hypertension treatment strategy for patients with coronary artery disease. The International Verapamil-Trandolapril Study (INVEST): a randomized controlled trial. JAMA. 290:2805–2816. 2003. View Article : Google Scholar

7 

AHA, heart disease and stroke statistics - 2005 update. American Heart Association; Dallas, TX, USA: 2004

8 

Chobanian AV, Bakris GL, Black HR, et al: Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension. 42:1206–1252. 2003. View Article : Google Scholar

9 

Wolz M, Cutler J, Roccella EJ, et al: Statement from the National High Blood Pressure Education Program: prevalence of hypertension. Am J Hypertens. 13:103–104. 2000. View Article : Google Scholar : PubMed/NCBI

10 

Vasan RS, Beiser A, Seshadri S, et al: Residual lifetime risk for developing hypertension in middle-aged women and men: The Framingham Heart Study. JAMA. 287:1003–1010. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Rosenthal T and Oparil S: Hypertension in women. J Hum Hypertens. 14:691–704. 2000. View Article : Google Scholar

12 

Reis SE, Holubkov R, Conrad Smith AJ, et al: Coronary microvascular dysfunction is highly prevalent in women with chest pain in the absence of coronary artery disease: results from the NHLBI WISE study. Am Heart J. 141:735–741. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Rosengren A, Wallentin L, Gitt AK, et al: Sex, age, and clinical presentation of acute coronary syndromes. Eur Heart J. 25:663–670. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Gulli G, Cemin R, Pancera P, et al: Evidence of parasympathetic impairment in some patients with cardiac syndrome X. Cardiovasc Res. 52:208–216. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Iriarte M, Caso R, Murga N, et al: Microvascular angina pectoris in hypertensive patients with left ventricular hypertrophy and diagnostic value of exercise thallium-201 scintigraphy. Am J Cardiol. 75:335–339. 1995. View Article : Google Scholar : PubMed/NCBI

16 

Schwartzkopff B, Motz W, Frenzel H, et al: Structural and functional alterations of the intramyocardial coronary arterioles in patients with arterial hypertension. Circulation. 88:993–1003. 1993. View Article : Google Scholar : PubMed/NCBI

17 

Jaffe LS and Seely EW: The heterogeneity of the blood pressure response to hormonal contraceptives. Curr Opin Endocrinol Diabetes. 2:257–265. 1995. View Article : Google Scholar

18 

Appel LJ, Champagne CM, Harsha DW, et al: Effects of comprehensive lifestyle modification on blood pressure control: main results of the PREMIER clinical trial. JAMA. 289:2083–2093. 2003.PubMed/NCBI

19 

Staessen J, Bulpitt CJ, Fagard R, et al: The influence of menopause on blood pressure. J Hum Hypertens. 3:427–433. 1989.

20 

McIntyre M, Hamilton CA, Rees DD, et al: Sex differences in the abundance of endothelial nitric oxide in a model of genetic hypertension. Hypertension. 30:1517–1524. 1997. View Article : Google Scholar : PubMed/NCBI

21 

Duvernoy C, Martin J, Briesmiester K, et al: Myocardial blood flow and flow reserve in response to hormone therapy in postmenopausal women with risk factors for coronary disease. J Clin Endocrinol Metab. 89:2783–2788. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Hajjar I and Kotchen TA: Trends in prevalence, awareness, treatment, and control of hypertension in the United States, 1988–2000. JAMA. 290:199–206. 2003.

23 

Cushman WC, Ford CE, Cutler JA, et al: Success and predictors of blood pressure control in diverse North American settings: the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT). J Clin Hypertens (Greenwich). 4:393–404. 2002.

24 

Mosca L, Manson JE, Sutherland SE, et al: Cardiovascular disease in women: a statement for healthcare professionals from the American Heart Association. Writing Group. Circulation. 96:2468–2482. 1997. View Article : Google Scholar : PubMed/NCBI

25 

Mukherjee D, Fang J, Chetcuti S, et al: Impact of combination evidence-based medical therapy on mortality in patients with acute coronary syndromes. Circulation. 109:745–749. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Fox KA, Goodman SG, Anderson FA Jr, et al: From guidelines to clinical practice: the impact of hospital and geographical characteristics on temporal trends in the management of acute coronary syndromes. The Global Registry of Acute Coronary Events (GRACE). Eur Heart J. 24:1414–1424. 2003. View Article : Google Scholar

27 

Hochman JS, McCabe CH, Stone PH, et al: Outcome and profile of women and men presenting with acute coronary syndromes: a report from TIMI IIIB. TIMI Investigators. Thrombolysis in Myocardial Infarction. J Am Coll Cardiol. 30:141–148. 1997. View Article : Google Scholar : PubMed/NCBI

28 

The Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) IIb Investigators. A comparison of recombinant hirudin with heparin for the treatment of acute coronary syndromes. N Engl J Med. 335:775–782. 1996. View Article : Google Scholar : PubMed/NCBI

29 

Becker RC, Terrin M, Ross R, et al: Comparison of clinical outcomes for women and men after acute myocardial infarction. The Thrombolysis in Myocardial Infarction Investigators. Ann Intern Med. 120:638–645. 1994. View Article : Google Scholar : PubMed/NCBI

30 

Tunstall-Pedoe H, Morrison C, Woodward M, et al: Sex differences in myocardial infarction and coronary deaths in the Scottish MONICA population of Glasgow 1985 to 1991. Presentation, diagnosis, treatment, and 28-day case fatality of 3991 events in men and 1551 events in women. Circulation. 93:1981–1992. 1996. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Lin Y, Pan W, Ning S, Song X, Jin Z and Lv S: Prevalence and management of hypertension in patients with acute coronary syndrome vary with gender: Observations from the Chinese registry of acute coronary events (CRACE). Mol Med Rep 8: 173-177, 2013.
APA
Lin, Y., Pan, W., Ning, S., Song, X., Jin, Z., & Lv, S. (2013). Prevalence and management of hypertension in patients with acute coronary syndrome vary with gender: Observations from the Chinese registry of acute coronary events (CRACE). Molecular Medicine Reports, 8, 173-177. https://doi.org/10.3892/mmr.2013.1461
MLA
Lin, Y., Pan, W., Ning, S., Song, X., Jin, Z., Lv, S."Prevalence and management of hypertension in patients with acute coronary syndrome vary with gender: Observations from the Chinese registry of acute coronary events (CRACE)". Molecular Medicine Reports 8.1 (2013): 173-177.
Chicago
Lin, Y., Pan, W., Ning, S., Song, X., Jin, Z., Lv, S."Prevalence and management of hypertension in patients with acute coronary syndrome vary with gender: Observations from the Chinese registry of acute coronary events (CRACE)". Molecular Medicine Reports 8, no. 1 (2013): 173-177. https://doi.org/10.3892/mmr.2013.1461
Copy and paste a formatted citation
x
Spandidos Publications style
Lin Y, Pan W, Ning S, Song X, Jin Z and Lv S: Prevalence and management of hypertension in patients with acute coronary syndrome vary with gender: Observations from the Chinese registry of acute coronary events (CRACE). Mol Med Rep 8: 173-177, 2013.
APA
Lin, Y., Pan, W., Ning, S., Song, X., Jin, Z., & Lv, S. (2013). Prevalence and management of hypertension in patients with acute coronary syndrome vary with gender: Observations from the Chinese registry of acute coronary events (CRACE). Molecular Medicine Reports, 8, 173-177. https://doi.org/10.3892/mmr.2013.1461
MLA
Lin, Y., Pan, W., Ning, S., Song, X., Jin, Z., Lv, S."Prevalence and management of hypertension in patients with acute coronary syndrome vary with gender: Observations from the Chinese registry of acute coronary events (CRACE)". Molecular Medicine Reports 8.1 (2013): 173-177.
Chicago
Lin, Y., Pan, W., Ning, S., Song, X., Jin, Z., Lv, S."Prevalence and management of hypertension in patients with acute coronary syndrome vary with gender: Observations from the Chinese registry of acute coronary events (CRACE)". Molecular Medicine Reports 8, no. 1 (2013): 173-177. https://doi.org/10.3892/mmr.2013.1461
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