Decreased expression of miR-430 promotes the development of bladder cancer via the upregulation of CXCR7

  • Authors:
    • Lei Liu
    • Xiaokun Zhao
    • Xuan Zhu
    • Zhaohui Zhong
    • Ran Xu
    • Zijian Wang
    • Jian Cao
    • Yi Hou
  • View Affiliations

  • Published online on: May 16, 2013     https://doi.org/10.3892/mmr.2013.1477
  • Pages: 140-146
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Abstract

MicroRNAs (miRNAs) have been demonstrated to be involved in the development of numerous types of malignant tumor. However, the role of miRNA-430 (miR-430) in bladder cancer remains unclear. In the present study, we observed that the expression of miR-430 was significantly downregulated in bladder cancer. Furthermore, the overexpression of miR-430 in human bladder cancer 5637 cells significantly inhibited cell proliferation, migration and colony formation efficiency. These findings were contrary to those obtained following the overexpression of CXCR7, which was found to be a direct target of miR-430 in this study. Further analysis showed that cell proliferation- and migration-related genes, including ERK, matrix metalloproteinase-2 (MMP-2) and MMP-9, were significantly downregulated in miR-430 overexpressed 5637 cells, while they were markedly upregulated in CXCR7 overexpressed 5637 cells. In conclusion, our study reveals important roles of miR-430 and CXCR7 in bladder cancer, and suggests that the downregulation of miR-430 enhances the development of bladder cancer, partly via the upregulation of CXCR7.
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July 2013
Volume 8 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Liu L, Zhao X, Zhu X, Zhong Z, Xu R, Wang Z, Cao J and Hou Y: Decreased expression of miR-430 promotes the development of bladder cancer via the upregulation of CXCR7. Mol Med Rep 8: 140-146, 2013
APA
Liu, L., Zhao, X., Zhu, X., Zhong, Z., Xu, R., Wang, Z. ... Hou, Y. (2013). Decreased expression of miR-430 promotes the development of bladder cancer via the upregulation of CXCR7. Molecular Medicine Reports, 8, 140-146. https://doi.org/10.3892/mmr.2013.1477
MLA
Liu, L., Zhao, X., Zhu, X., Zhong, Z., Xu, R., Wang, Z., Cao, J., Hou, Y."Decreased expression of miR-430 promotes the development of bladder cancer via the upregulation of CXCR7". Molecular Medicine Reports 8.1 (2013): 140-146.
Chicago
Liu, L., Zhao, X., Zhu, X., Zhong, Z., Xu, R., Wang, Z., Cao, J., Hou, Y."Decreased expression of miR-430 promotes the development of bladder cancer via the upregulation of CXCR7". Molecular Medicine Reports 8, no. 1 (2013): 140-146. https://doi.org/10.3892/mmr.2013.1477