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Article Open Access

Inhibition of AGS human gastric cancer cell invasion and proliferation by Capsosiphon fulvescens glycoprotein

  • Authors:
    • Young‑Min Kim
    • In‑Hye Kim
    • Taek‑Jeong Nam
  • View Affiliations / Copyright

    Affiliations: Institute of Fisheries Sciences, Pukyong National University, Ilgwang-ro, Ilgwang‑myeon, Gijang-gun, Busan 619-911, Republic of Korea
    Copyright: © Kim et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 11-16
    |
    Published online on: May 27, 2013
       https://doi.org/10.3892/mmr.2013.1492
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Abstract

Seaweeds are increasingly being used as foodstuffs and therapeutics. Capsosiphon fulvescens (C. fulvescens) is a green sea alga which has demonstrated anti‑tumor activity in various cancer cell lines. In cancer cells, homeostasis is not maintained, enabling mutations to develop and growth to continue unchecked. Overexpression of matrix metalloproteinase (MMP) and tight junction (TJ) proteins is important for cancer cell proliferation, invasion and metastasis. In addition, these proteins are closely associated with cell membrane permeability. In the current study, C. fulvescens glycoprotein (Cf‑GP) was found to inhibit TJ proteins and invasion of AGS human gastric cancer cells. Cf‑GP‑mediated inhibition of cell proliferation and invasion was confirmed, as well as changes in TJ protein levels. In addition, MMP‑2 and ‑9 activities were inhibited, as indicated by increased transepithelial electrical resistance. Inhibition of MMP protein expression was also found to correlate with tissue inhibitor of metalloproteinase 1 and Cf‑GP treatment, as revealed by western blot analysis and RT‑PCR. In conclusion, these results indicate that Cf‑GP inhibits cancer cell invasion and therefore demonstrates a potential therapeutic strategy to decrease cancer metastasis.
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1 

Bishop JM: The molecular genetics of cancer. Science. 235:305–311. 1987. View Article : Google Scholar : PubMed/NCBI

2 

Kim SO, Choi YH and Choe WK: Indol-3-carbinol regulated tight junction permeability and associated-protein level and suppressed cell invasion in human colon cancer cell line, HT-29. Korean J Nutr. 41:13–21. 2008.

3 

Higashi-Okaj K, Otani S and Okai Y: Potent suppressive effect of a Japanese edible seaweed, Enteromorpha prolifera (Sujiao-nori) on initiation and promotion phases of chemically induced mouse skin tumorigenesis. Cancer Lett. 140:21–25. 1999.PubMed/NCBI

4 

Okai Y, Higashi-Okai K, Nakamura S, Yano Y and Otani S: Suppressive effects of the extracts of Japanese edible seaweeds on mutagen-induced umu C gene expression in Salmonella typhimurium (TA 1535/pSK 1002) and tumor promoter-dependent ornithine decarboxylase induction in BALB/c 3T3 fibroblast cells. Cancer Lett. 87:25–32. 1994. View Article : Google Scholar : PubMed/NCBI

5 

Yamamoto I, Maruyama H and Moriguchi M: The effect of dietary seaweeds on 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis in rats. Cancer Lett. 35:109–118. 1987.

6 

Noda H, Amano H, Arashima K and Nisizawa K: Antitumor activity of marine algae. Hydrobiologia. 204–205. 577–584. 1990.

7 

Kwon MJ and Nam TJ: Porphyran induces apoptosis related signal pathway in AGS gastric cancer cell lines. Life Sci. 79:1956–1962. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Go H, Hwang HJ and Nam TJ: A glycoprotein from Laminaria japonica induces apoptosis in HT-29 colon cancer cells. Toxicol in Vitro. 24:1546–1553. 2010.

9 

Hwang HJ, Kim IH and Nam TJ: Effect of a glycoprotein from Hizikia fusiformis on acetaminophen-induced liver injury. Food Chem Toxicol. 46:3475–3481. 2008.PubMed/NCBI

10 

Choi YH: Inhibition of cell invasion by ethyl alcohol extracts of Hizikia fusiforme in AGS human gastric adenocarcinoma cells. Korea J Life Sci. 20:1784–1791. 2010. View Article : Google Scholar

11 

Cho EK, Yoo SK and Choi YJ: Inhibitory effects of maesaengi (Capsosiphon fulvescens) extracts on angiotensin converting enzyme and α-glucosidase. Korea J Life Sci. 21:811–818. 2011.

12 

Park HY, Lim CW, Kim YK, Yoon HD and Lee KJ: Immunostimulating and anti-cancer activities of hot water extract from Capsosiphon fulvescens. J Korean Soc Appl Biol Chem. 49:343–348. 2006.

13 

Kim YM, Kim IH and Nam TJ: Induction of apoptosis signaling by a glycoprotein of Capsosiphon fulvescens in AGS cell. Kor J Fish Aquat Sci. 44:216–224. 2011.

14 

Peralta SA, Mullin JM, Knudsen KA and Marano CW: Tissue remodeling during tumor necrosis factor-induced apoptosis in LLC-PK1 renal epithelial cells. Am J Physiol. 270:F869–F879. 1996.PubMed/NCBI

15 

Swift JG, Mukherjee TM and Rowland R: Intercellular junctions in hepatocellular carcinoma. J Submicrosc Cytol. 15:799–810. 1983.PubMed/NCBI

16 

Van Itallie CM and Anderson JM: The molecular physiology of tight junction pores. Physiology (Bethesda). 19:331–338. 2004.PubMed/NCBI

17 

Kim YM, Kim IH and Nam TJ: Induction of apoptosis signaling by glycoprotein of Capsosiphon fulvescens in human gastric cancer (AGS) cells. Nutr cancer. 64:761–769. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Lamszus K, Kunkel P and Westphal M: Invasion as limitation to anti-angiogenic glioma therapy. Acta Neurochir Suppl. 88:169–177. 2003.PubMed/NCBI

19 

Duffy MJ, Maguire TM, Hill A, McDermott E and O'Higgins N: Metalloproteinases: role in breast carcinogenesis, invasion and metastasis. Breast Cancer Res. 2:252–257. 2000. View Article : Google Scholar : PubMed/NCBI

20 

Curry JD, Glaser MC and Smith MT: Real-time reverse transcription polymerase chain reaction detection and quantification of t(1;19)(E2A-PBX1) fusion genes associated with leukemia. Br J Haematol. 115:826–830. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Park HS, Kim GY, Choi IW, Kim ND, Hwang HJ, Choi YW and Choi YH: Inhibition of matrix metalloproteinase activities and tightening of tight junctions by diallyl disulfide in AGS human gastric carcinoma cells. J Food Sci. 76:T105–T111. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Coussens LM and Werb Z: Matrix metalloproteinases and the development of cancer. Chem Biol. 3:895–904. 1996. View Article : Google Scholar : PubMed/NCBI

23 

Bennett JH, Morgan MJ, Whawell SA, Atkin P, Roblin P, Furness J and Speight PM: Metalloproteinase expression in normal and malignant oral keratinocytes: stimulation of MMP-2 and MMP-9 by scatter factor. Eur J Oral Sci. 108:281–291. 2000. View Article : Google Scholar : PubMed/NCBI

24 

Ylisirniö S, Höyhtyä M and Turpeenniemi-Hujanen T: Serum matrix metalloproteinases −2, −9 and tissue inhibitors of metalloproteinases −1, −2 in lung cancer-TIMP-1 as a prognostic marker. Anticancer Res. 20:1311–1316. 2000.

25 

Song ES, Lee BI, Kim JM, Lee KY, An KS, Sung SM, Kwon HJ, Park JH, Han JY and Choi SJ: Increase expressions of claudin-1 and claudin-7 in cervical squamous intraepithelial neoplasias and invasive squamous cell carcinomas. Korean J Obstet Gynecol. 49:1065–1072. 2006.

26 

Langbein L, Grund C, Kuhn C, Praetzel S, Kartenbeck J, Brandner JM, Moll I and Franke WW: Tight junctions and compositionally related junctional structures in mammalian stratified epithelia and cell cultures derived therefrom. Eur J Cell Biol. 81:419–435. 2002. View Article : Google Scholar

27 

Tsukita S and Furuse M: Pores in the wall: claudins constitute tight junction strands containing aqueous pores. J Cell Biol. 149:13–16. 2000. View Article : Google Scholar : PubMed/NCBI

28 

Agarwal R, D'Souza T and Morin PJ: Claudin-3 and claudin-4 expression in ovarian epithelial cells enhances invasion and is associated with increased matrix metalloproteinase-2 activity. Cancer Res. 65:7378–7385. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Balda MS, Garrett MD and Matter K: The ZO-1-associated Y-box factor ZONAB regulates epithelial cell proliferation and cell density. J Cell Biol. 160:423–432. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Lee H, Kim D, Sohn D, Jeong B, Choi H, Sim K, Lee K, Cho H, Kim S, Lee J, Jeong Y, Kim S, Lee W and Kim K: The changes of occludin in tight junction of blood-brain barrier by ROS. Korean J Electron Microscopy. 34:231–239. 2004.

31 

Tunggal JA, Helfrich I, Schmitz A, Schwarz H, Günzel D, Fromm M, Kemler R, Krieg T and Niessen CM: E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J. 24:1146–1156. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Mess ST, Mennigen R, Spieker T, Rijcken E, Senninger N, Haier J and Bruewer M: Expression of tight and adherens junction proteins in ulcerative colitis associated colorectal carcinoma: upregulation of claudin-1, claudin-3, claudin-4 and β-catenin. Int J Colorectal Dis. 24:361–368. 2009.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Kim YM, Kim IH and Nam TJ: Inhibition of AGS human gastric cancer cell invasion and proliferation by Capsosiphon fulvescens glycoprotein. Mol Med Rep 8: 11-16, 2013.
APA
Kim, Y., Kim, I., & Nam, T. (2013). Inhibition of AGS human gastric cancer cell invasion and proliferation by Capsosiphon fulvescens glycoprotein. Molecular Medicine Reports, 8, 11-16. https://doi.org/10.3892/mmr.2013.1492
MLA
Kim, Y., Kim, I., Nam, T."Inhibition of AGS human gastric cancer cell invasion and proliferation by Capsosiphon fulvescens glycoprotein". Molecular Medicine Reports 8.1 (2013): 11-16.
Chicago
Kim, Y., Kim, I., Nam, T."Inhibition of AGS human gastric cancer cell invasion and proliferation by Capsosiphon fulvescens glycoprotein". Molecular Medicine Reports 8, no. 1 (2013): 11-16. https://doi.org/10.3892/mmr.2013.1492
Copy and paste a formatted citation
x
Spandidos Publications style
Kim YM, Kim IH and Nam TJ: Inhibition of AGS human gastric cancer cell invasion and proliferation by Capsosiphon fulvescens glycoprotein. Mol Med Rep 8: 11-16, 2013.
APA
Kim, Y., Kim, I., & Nam, T. (2013). Inhibition of AGS human gastric cancer cell invasion and proliferation by Capsosiphon fulvescens glycoprotein. Molecular Medicine Reports, 8, 11-16. https://doi.org/10.3892/mmr.2013.1492
MLA
Kim, Y., Kim, I., Nam, T."Inhibition of AGS human gastric cancer cell invasion and proliferation by Capsosiphon fulvescens glycoprotein". Molecular Medicine Reports 8.1 (2013): 11-16.
Chicago
Kim, Y., Kim, I., Nam, T."Inhibition of AGS human gastric cancer cell invasion and proliferation by Capsosiphon fulvescens glycoprotein". Molecular Medicine Reports 8, no. 1 (2013): 11-16. https://doi.org/10.3892/mmr.2013.1492
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