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Article

Sequence‑dependent effect of gemcitabine and cisplatin on A549 non‑small‑cell lung cancer cells

  • Authors:
    • Yu Tang
    • Yan Wang
    • Xiuzhi Teng
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, Liaoning Tumor Hospital, Shenyang, Liaoning 110042, P.R. China, Department of Surgery, Center Hospital of Liaoning Electric Power, Shenyang, Liaoning 110015, P.R. China
  • Pages: 221-226
    |
    Published online on: May 28, 2013
       https://doi.org/10.3892/mmr.2013.1495
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Abstract

Cis‑diamminedichloroplatinum (cisplatin, CDDP)‑containing combination chemotherapy is commonly used for the treatment of non‑small‑cell lung cancer (NSCLC). 2',2'‑Difluorodeoxycytidine (gemcitabine, GEM), an active antineoplastic agent for NSCLC, has been previously reported to be suitable for use in combination with cisplatin in chemotherapy, since their mechanisms may be complementary. In the present study, the sequence‑dependent effects of GEM and CDDP were investigated in the NSCLC cell line, A549. Significantly increased rates of inhibition and cell cycle arrest were observed in the group treated with GEM followed by CDDP, and this treatment plan was demonstrated to represent the most efficient treatment protocol for the A549 NSCLC cell line. Results of the present study are consistent with previous studies in other cell lines and are likely to provide important insight for subsequent studies.
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Copy and paste a formatted citation
Spandidos Publications style
Tang Y, Wang Y and Teng X: Sequence‑dependent effect of gemcitabine and cisplatin on A549 non‑small‑cell lung cancer cells. Mol Med Rep 8: 221-226, 2013.
APA
Tang, Y., Wang, Y., & Teng, X. (2013). Sequence‑dependent effect of gemcitabine and cisplatin on A549 non‑small‑cell lung cancer cells. Molecular Medicine Reports, 8, 221-226. https://doi.org/10.3892/mmr.2013.1495
MLA
Tang, Y., Wang, Y., Teng, X."Sequence‑dependent effect of gemcitabine and cisplatin on A549 non‑small‑cell lung cancer cells". Molecular Medicine Reports 8.1 (2013): 221-226.
Chicago
Tang, Y., Wang, Y., Teng, X."Sequence‑dependent effect of gemcitabine and cisplatin on A549 non‑small‑cell lung cancer cells". Molecular Medicine Reports 8, no. 1 (2013): 221-226. https://doi.org/10.3892/mmr.2013.1495
Copy and paste a formatted citation
x
Spandidos Publications style
Tang Y, Wang Y and Teng X: Sequence‑dependent effect of gemcitabine and cisplatin on A549 non‑small‑cell lung cancer cells. Mol Med Rep 8: 221-226, 2013.
APA
Tang, Y., Wang, Y., & Teng, X. (2013). Sequence‑dependent effect of gemcitabine and cisplatin on A549 non‑small‑cell lung cancer cells. Molecular Medicine Reports, 8, 221-226. https://doi.org/10.3892/mmr.2013.1495
MLA
Tang, Y., Wang, Y., Teng, X."Sequence‑dependent effect of gemcitabine and cisplatin on A549 non‑small‑cell lung cancer cells". Molecular Medicine Reports 8.1 (2013): 221-226.
Chicago
Tang, Y., Wang, Y., Teng, X."Sequence‑dependent effect of gemcitabine and cisplatin on A549 non‑small‑cell lung cancer cells". Molecular Medicine Reports 8, no. 1 (2013): 221-226. https://doi.org/10.3892/mmr.2013.1495
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