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Review

Local gene transfection in the cochlea (Review)

  • Authors:
    • Li Xia
    • Shankai Yin
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology, The Sixth People's Hospital Affiliated to The Shanghai Jiao Tong University, Otolaryngology Institute of The Shanghai Jiao Tong University, Shanghai 200233, P.R. China
  • Pages: 3-10
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    Published online on: May 28, 2013
       https://doi.org/10.3892/mmr.2013.1496
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Abstract

There is much interest in the potential application of vector-induced gene therapeutic approaches to several forms of hearing disorders due to the poor efficacy of existing treatments. The cochlea is an ideal site for local gene transfection due to its anatomical encapsulation and fluid flow within its ducts. However, this requires the development of novel technologies in materials science and microbial supply vectors for target gene delivery. This review focuses on the introduction of various viral and non-viral vectors as well as injection approaches to transfecting cochlear cells in vivo. Finally, the perspective of local gene therapy was discussed. Therapeutic approaches using local gene transfection may provide a means of cochlear cell and tissue protection and treatment in cases of exogenous hearing loss and endogenous disorders.
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1 

Henry KR, Chole RA, McGinn MD and Frush DP: Increased ototoxicity in both young and old mice. Arch Otolaryngol. 107:92–95. 1981. View Article : Google Scholar : PubMed/NCBI

2 

Ishiyama G, Ishiyama A, Kerber K and Baloh RW: Gentamicin ototoxicity: clinical features and the effect on the human vestibulo-ocular reflex. Acta Otolaryngol. 126:1057–1061. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Eshraghi AA, Frachet B, Van De Water TR and Eter E: Hearing loss in adults. Rev Prat. 59:645–652. 2009.(In French).

4 

Fetoni AR, Mancuso C, Eramo SL, et al: In vivo protective effect of ferulic acid against noise-induced hearing loss in the guinea pig. Neuroscience. 169:1575–1588. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Campbell KC, Meech RP, Klemens JJ, et al: Prevention of noise- and drug-induced hearing loss with D-methionine. Hear Res. 226:92–103. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Lee CK, Shin JI and Cho YS: Protective effect of minocycline against cisplatin-induced ototoxicity. Clin Exp Otorhinolaryngol. 4:77–82. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Maniu A, Perde-Schrepler M and Cosgarea M: Protective effect of L-N-acetylcysteine against gentamycin ototoxicity in the organ cultures of the rat cochlea. Rom J Morphol Embryol. 52:159–164. 2011.PubMed/NCBI

8 

Agrup C, Gleeson M and Rudge P: The inner ear and the neurologist. J Neurol Neurosurg Psychiatry. 78:114–122. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Swan EE, Mescher MJ, Sewell WF, Tao SL and Borenstein JT: Inner ear drug delivery for auditory applications. Adv Drug Deliv Rev. 60:1583–1599. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Staecker H, Gabaizadeh R, Federoff H and Van De Water TR: Brain-derived neurotrophic factor gene therapy prevents spiral ganglion degeneration after hair cell loss. Otolaryngol Head Neck Surg. 119:7–13. 1998.PubMed/NCBI

11 

Suzuki M, Yamasoba T, Suzukawa K and Kaga K: Adenoviral vector gene delivery via the round window membrane in guinea pigs. Neuroreport. 14:1951–1955. 2003. View Article : Google Scholar : PubMed/NCBI

12 

Duan M, Venail F, Spencer N and Mezzina M: Treatment of peripheral sensorineural hearing loss: gene therapy. Gene Ther. 11(Suppl 1): S51–S56. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Praetorius M, Pfannenstiel S, Klingmann C, Baumann I, Plinkert PK and Staecker H: Expression patterns of non-viral transfection with GFP in the organ of Corti in vitro and in vivo. Gene therapy of the inner ear with non-viral vectors. HNO. 56:524–529. 2008.(In German).

14 

Cooper LB, Chan DK, Roediger FC, et al: AAV-mediated delivery of the caspase inhibitor XIAP protects against cisplatin ototoxicity. Otol Neurotol. 27:484–490. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Jiang M, Zhang YQ, He GX and Sun H: Protective effect of NT-3 gene mediated by hydroxyapatite nanoparticle on the cochlea of guinea pigs injured by excitotoxicity. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 32:563–567. 2007.(In Chinese).

16 

Kawamoto K, Ishimoto S, Minoda R, Brough DE and Raphael Y: Math1 gene transfer generates new cochlear hair cells in mature guinea pigs in vivo. J Neurosci. 23:4395–4400. 2003.PubMed/NCBI

17 

Ylikoski J, Pirvola U, Virkkala J, et al: Guinea pig auditory neurons are protected by glial cell line-derived growth factor from degeneration after noise trauma. Hear Res. 124:17–26. 1998. View Article : Google Scholar : PubMed/NCBI

18 

Ghilardi JR, Freeman KT, Jimenez-Andrade JM, et al: Sustained blockade of neurotrophin receptors TrkA, TrkB and TrkC reduces non-malignant skeletal pain but not the maintenance of sensory and sympathetic nerve fibers. Bone. 48:389–398. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Michael AE, Collins TD, Norgate DP, Gregory L, Wood PJ and Cooke BA: Relationship between ovarian cortisol:cortisone ratios and the clinical outcome of in vitro fertilization and embryo transfer (IVF-ET). Clin Endocrinol (Oxf). 51:535–540. 1999. View Article : Google Scholar : PubMed/NCBI

20 

Carnicero E, Garrido JJ, Alonso MT and Schimmang T: Roles of fibroblast growth factor 2 during innervation of the avian inner ear. J Neurochem. 77:786–795. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Frolenkov GI, Belyantseva IA, Kurc M, Mastroianni MA and Kachar B: Cochlear outer hair cell electromotility can provide force for both low and high intensity distortion product otoacoustic emissions. Hear Res. 126:67–74. 1998. View Article : Google Scholar : PubMed/NCBI

22 

Liberman MC, Zuo J and Guinan JJ Jr: Otoacoustic emissions without somatic motility: can stereocilia mechanics drive the mammalian cochlea? J Acoust Soc Am. 116:1649–1655. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Ye HB, Shi HB, Wang J, et al: Bilirubin induces auditory neuropathy in neonatal guinea pigs via auditory nerve fiber damage. J Neurosci Res. 90:2201–2213. 2012. View Article : Google Scholar : PubMed/NCBI

24 

El-Badry MM and McFadden SL: Electrophysiological correlates of progressive sensorineural pathology in carboplatin-treated chinchillas. Brain Res. 1134:122–130. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Xia L, Yin S and Wang J: Inner ear gene transfection in neonatal mice using adeno-associated viral vector: a comparison of two approaches. PLoS One. 7:e432182012. View Article : Google Scholar : PubMed/NCBI

26 

Landry TG, Wise AK, Fallon JB and Shepherd RK: Spiral ganglion neuron survival and function in the deafened cochlea following chronic neurotrophic treatment. Hear Res. 282:303–313. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Walton JP, Barsz K and Wilson WW: Sensorineural hearing loss and neural correlates of temporal acuity in the inferior colliculus of the C57BL/6 mouse. J Assoc Res Otolaryngol. 9:90–101. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Wang H, Yin S, Yu Z, Huang Y and Wang J: Dynamic changes in hair cell stereocilia and cochlear transduction after noise exposure. Biochem Biophys Res Commun. 409:616–621. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Yang SM, Doi T, Asako M, Matsumoto A and Yamashita T: Optical recording of membrane potential in dissociated mouse vestibular ganglion cells using a voltage-sensitive dye. Auris Nasus Larynx. 27:15–21. 2000. View Article : Google Scholar : PubMed/NCBI

30 

Poirrier AL, Van den Ackerveken P, Kim TS, et al: Ototoxic drugs: difference in sensitivity between mice and guinea pigs. Toxicol Lett. 193:41–49. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Ishimoto S, Kawamoto K, Stöver T, Kanzaki S, Yamasoba T and Raphael Y: A glucocorticoid reduces adverse effects of adenovirus vectors in the cochlea. Audiol Neurootol. 8:70–79. 2003. View Article : Google Scholar : PubMed/NCBI

32 

Wang H, Murphy R, Taaffe D, et al: Efficient cochlear gene transfection in guinea-pigs with adeno-associated viral vectors by partial digestion of round window membrane. Gene Ther. 19:255–263. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Maeda Y, Fukushima K, Kawasaki A, Nishizaki K and Smith RJ: Cochlear expression of a dominant-negative GJB2R75W construct delivered through the round window membrane in mice. Neurosci Res. 58:250–254. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Sun H, Jiang M and Zhu SH: In vitro and in vivo studies on hydroxyapatite nanoparticles as a novel vector for inner ear gene therapy. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 43:51–57. 2008.(In Chinese).

35 

Lalwani AK and Mhatre AN: Cochlear gene therapy. Ear Hear. 24:342–348. 2003. View Article : Google Scholar : PubMed/NCBI

36 

Thomas CE, Ehrhardt A and Kay MA: Progress and problems with the use of viral vectors for gene therapy. Nat Rev Genet. 4:346–358. 2003. View Article : Google Scholar : PubMed/NCBI

37 

Dimitrov EA and Duckert LG: Morphologic changes in the guinea pig cochlea following cochleostomy - a preliminary scanning electron microscope study. Otolaryngol Head Neck Surg. 93:408–413. 1985.

38 

Iizuka T, Kanzaki S, Mochizuki H, et al: Noninvasive in vivo delivery of transgene via adeno-associated virus into supporting cells of the neonatal mouse cochlea. Hum Gene Ther. 19:384–390. 2008. View Article : Google Scholar : PubMed/NCBI

39 

Kesser BW and Lalwani AK: Gene therapy and stem cell transplantation: strategies for hearing restoration. Adv Otorhinolaryngol. 66:64–86. 2009.PubMed/NCBI

40 

Newton VE: Aetiology of bilateral sensori-neural hearing loss in young children. J Laryngol Otol Suppl. 10:1–57. 1985.PubMed/NCBI

41 

Qu C, Gardner P and Schrijver I: The role of the cytoskeleton in the formation of gap junctions by Connexin 30. Exp Cell Res. 315:1683–1692. 2009. View Article : Google Scholar : PubMed/NCBI

42 

Holt JR: Viral-mediated gene transfer to study the molecular physiology of the Mammalian inner ear. Audiol Neurootol. 7:157–160. 2002. View Article : Google Scholar : PubMed/NCBI

43 

Yagi M, Magal E, Sheng Z, Ang KA and Raphael Y: Hair cell protection from aminoglycoside ototoxicity by adenovirus-mediated overexpression of glial cell line-derived neurotrophic factor. Hum Gene Ther. 10:813–823. 1999. View Article : Google Scholar : PubMed/NCBI

44 

Cheng G, Liu L, Wang P, et al: An in vivo transfection approach elucidates a role for Aedes aegypti thioester-containing proteins in flaviviral infection. PLoS One. 6:e227862011. View Article : Google Scholar : PubMed/NCBI

45 

Pfannenstiel SC, Praetorius M, Plinkert PK, Brough DE and Staecker H: Bcl-2 gene therapy prevents aminoglycoside-induced degeneration of auditory and vestibular hair cells. Audiol Neurootol. 14:254–266. 2009. View Article : Google Scholar : PubMed/NCBI

46 

Shou J, Zheng JL and Gao WQ: Robust generation of new hair cells in the mature mammalian inner ear by adenoviral expression of Hath1. Mol Cell Neurosci. 23:169–179. 2003. View Article : Google Scholar : PubMed/NCBI

47 

Jero J, Mhatre AN, Tseng CJ, et al: Cochlear gene delivery through an intact round window membrane in mouse. Hum Gene Ther. 12:539–548. 2001. View Article : Google Scholar : PubMed/NCBI

48 

Derby ML, Sena-Esteves M, Breakefield XO and Corey DP: Gene transfer into the mammalian inner ear using HSV-1 and vaccinia virus vectors. Hear Res. 134:1–8. 1999. View Article : Google Scholar : PubMed/NCBI

49 

Lei L and Han D: Efficient transduction of spiral ganglion cells using adenovirus type 5 vector in the rat. Acta Otolaryngol. 130:810–814. 2010. View Article : Google Scholar : PubMed/NCBI

50 

Duan ML, Ulfendahl M, Laurell G, et al: Protection and treatment of sensorineural hearing disorders caused by exogenous factors: experimental findings and potential clinical application. Hear Res. 169:169–178. 2002. View Article : Google Scholar

51 

Luebke AE, Foster PK, Muller CD and Peel AL: Cochlear function and transgene expression in the guinea pig cochlea, using adenovirus- and adeno-associated virus-directed gene transfer. Hum Gene Ther. 12:773–781. 2001. View Article : Google Scholar : PubMed/NCBI

52 

Luebke AE, Steiger JD, Hodges BL and Amalfitano A: A modified adenovirus can transfect cochlear hair cells in vivo without compromising cochlear function. Gene Ther. 8:789–794. 2001. View Article : Google Scholar : PubMed/NCBI

53 

Holt JR, Johns DC, Wang S, et al: Functional expression of exogenous proteins in mammalian sensory hair cells infected with adenoviral vectors. J Neurophysiol. 81:1881–1888. 1999.PubMed/NCBI

54 

Ishimoto S, Kawamoto K, Stover T, Kanzaki S, Yamasoba T and Raphael Y: A glucocorticoid reduces adverse effects of adenovirus vectors in the cochlea. Audiol Neurootol. 8:70–79. 2003. View Article : Google Scholar : PubMed/NCBI

55 

Li Duan M, Bordet T, Mezzina M, Kahn A and Ulfendahl M: Adenoviral and adeno-associated viral vector mediated gene transfer in the guinea pig cochlea. Neuroreport. 13:1295–1299. 2002.PubMed/NCBI

56 

Lalwani A, Walsh B, Reilly P, et al: Long-term in vivo cochlear transgene expression mediated by recombinant adeno-associated virus. Gene Ther. 5:277–281. 1998. View Article : Google Scholar : PubMed/NCBI

57 

Stone IM, Lurie DI, Kelley MW and Poulsen DJ: Adeno-associated virus-mediated gene transfer to hair cells and support cells of the murine cochlea. Mol Ther. 11:843–848. 2005. View Article : Google Scholar : PubMed/NCBI

58 

Lalwani AK, Walsh BJ, Reilly PG, Muzyczka N and Mhatre AN: Development of in vivo gene therapy for hearing disorders: introduction of adeno-associated virus into the cochlea of the guinea pig. Gene Ther. 3:588–592. 1996.

59 

Lalwani AK, Walsh BJ, Carvalho GJ, Muzyczka N and Mhatre AN: Expression of adeno-associated virus integrated transgene within the mammalian vestibular organs. Am J Otol. 19:390–395. 1998.PubMed/NCBI

60 

Kilpatrick LA, Li Q, Yang J, Goddard JC, Fekete DM and Lang H: Adeno-associated virus-mediated gene delivery into the scala media of the normal and deafened adult mouse ear. Gene Ther. 18:569–578. 2011. View Article : Google Scholar : PubMed/NCBI

61 

Liu Y, Okada T, Sheykholeslami K, et al: Specific and efficient transduction of Cochlear inner hair cells with recombinant adeno-associated virus type 3 vector. Mol Ther. 12:725–733. 2005. View Article : Google Scholar : PubMed/NCBI

62 

Walters RW, Yi SM, Keshavjee S, et al: Binding of adeno-associated virus type 5 to 2,3-linked sialic acid is required for gene transfer. J Biol Chem. 276:20610–20616. 2001. View Article : Google Scholar : PubMed/NCBI

63 

Xiao W, Chirmule N, Berta SC, McCullough B, Gao G and Wilson JM: Gene therapy vectors based on adeno-associated virus type 1. J Virol. 73:3994–4003. 1999.PubMed/NCBI

64 

Zhong L, Li B, Jayandharan G, et al: Tyrosine-phosphorylation of AAV2 vectors and its consequences on viral intracellular trafficking and transgene expression. Virology. 381:194–202. 2008. View Article : Google Scholar : PubMed/NCBI

65 

Chen X, Frisina RD, Bowers WJ, Frisina DR and Federoff HJ: HSV amplicon-mediated neurotrophin-3 expression protects murine spiral ganglion neurons from cisplatin-induced damage. Mol Ther. 3:958–963. 2001. View Article : Google Scholar : PubMed/NCBI

66 

Keithley EM, Woolf NK and Harris JP: Development of morphological and physiological changes in the cochlea induced by cytomegalovirus. Laryngoscope. 99:409–414. 1989. View Article : Google Scholar : PubMed/NCBI

67 

Stearns GS, Keithley EM and Harris JP: Development of high endothelial venule-like characteristics in the spiral modiolar vein induced by viral labyrinthitis. Laryngoscope. 103:890–898. 1993. View Article : Google Scholar : PubMed/NCBI

68 

Ailles LE and Naldini L: HIV-1-derived lentiviral vectors. Curr Top Microbiol Immunol. 261:31–52. 2002.PubMed/NCBI

69 

Blomer U, Naldini L, Kafri T, Trono D, Verma IM and Gage FH: Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector. J Virol. 71:6641–6649. 1997.PubMed/NCBI

70 

Han JJ, Mhatre AN, Wareing M, et al: Transgene expression in the guinea pig cochlea mediated by a lentivirus-derived gene transfer vector. Hum Gene Ther. 10:1867–1873. 1999. View Article : Google Scholar : PubMed/NCBI

71 

Felgner PL, Gadek TR, Holm M, et al: Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure. Proc Natl Acad Sci USA. 84:7413–7417. 1987. View Article : Google Scholar : PubMed/NCBI

72 

Wareing M, Mhatre AN, Pettis R, et al: Cationic liposome mediated transgene expression in the guinea pig cochlea. Hear Res. 128:61–69. 1999. View Article : Google Scholar : PubMed/NCBI

73 

Jero J, Tseng CJ, Mhatre AN and Lalwani AK: A surgical approach appropriate for targeted cochlear gene therapy in the mouse. Hear Res. 151:106–114. 2001. View Article : Google Scholar : PubMed/NCBI

74 

Beavis AD: On the inhibition of the mitochondrial inner membrane anion uniporter by cationic amphiphiles and other drugs. J Biol Chem. 264:1508–1515. 1989.PubMed/NCBI

75 

Bottega R and Epand RM: Inhibition of protein kinase C by cationic amphiphiles. Biochemistry. 31:9025–9030. 1992. View Article : Google Scholar : PubMed/NCBI

76 

Datiles MJ, Johnson EA and McCarty RE: Inhibition of the ATPase activity of the catalytic portion of ATP synthases by cationic amphiphiles. Biochim Biophys Acta. 1777:362–368. 2008. View Article : Google Scholar : PubMed/NCBI

77 

Tamura T, Kita T, Nakagawa T, et al: Drug delivery to the cochlea using PLGA nanoparticles. Laryngoscope. 115:2000–2005. 2005. View Article : Google Scholar : PubMed/NCBI

78 

Shimamura M, Morishita R, Endoh M, et al: HVJ-envelope vector for gene transfer into central nervous system. Biochem Biophys Res Commun. 300:464–471. 2003. View Article : Google Scholar : PubMed/NCBI

79 

Oshima K, Shimamura M, Mizuno S, et al: Intrathecal injection of HVJ-E containing HGF gene to cerebrospinal fluid can prevent and ameliorate hearing impairment in rats. FASEB J. 18:212–214. 2004.PubMed/NCBI

80 

Ishimoto S, Kawamoto K, Kanzaki S and Raphael Y: Gene transfer into supporting cells of the organ of Corti. Hear Res. 173:187–197. 2002. View Article : Google Scholar : PubMed/NCBI

81 

Yamasoba T, Yagi M, Roessler BJ, Miller JM and Raphael Y: Inner ear transgene expression after adenoviral vector inoculation in the endolymphatic sac. Hum Gene Ther. 10:769–774. 1999. View Article : Google Scholar : PubMed/NCBI

82 

Shibata SB, Di Pasquale G, Cortez SR, Chiorini JA and Raphael Y: Gene transfer using bovine adeno-associated virus in the guinea pig cochlea. Gene Ther. 16:990–997. 2009. View Article : Google Scholar : PubMed/NCBI

83 

Stover T, Yagi M and Raphael Y: Cochlear gene transfer: round window versus cochleostomy inoculation. Hear Res. 136:124–130. 1999. View Article : Google Scholar : PubMed/NCBI

84 

Konishi M, Kawamoto K, Izumikawa M, Kuriyama H and Yamashita T: Gene transfer into guinea pig cochlea using adeno-associated virus vectors. J Gene Med. 10:610–618. 2008. View Article : Google Scholar : PubMed/NCBI

85 

Nomura Y, Hara M and Kurata T: Experimental herpes simplex virus and cytomegalovirus labyrinthitis. Acta Otolaryngol Suppl. 457:57–66. 1989.PubMed/NCBI

86 

Weiss MA, Frisancho JC, Roessler BJ and Raphael Y: Viral-mediated gene transfer in the cochlea. Int J Dev Neurosci. 15:577–583. 1997. View Article : Google Scholar : PubMed/NCBI

87 

Nadol JB Jr: Intercellular junctions in the organ of Corti. Ann Otol Rhinol Laryngol. 87:70–80. 1978. View Article : Google Scholar : PubMed/NCBI

88 

Kimura RS: The ultrastructure of the organ of Corti. Int Rev Cytol. 42:173–222. 1975. View Article : Google Scholar : PubMed/NCBI

89 

Fritzsch B, Farinas I and Reichardt LF: Lack of neurotrophin 3 causes losses of both classes of spiral ganglion neurons in the cochlea in a region-specific fashion. J Neurosci. 17:6213–6225. 1997.PubMed/NCBI

90 

Griffith AJ, Ji W, Prince ME, Altschuler RA and Meisler MH: Optic, olfactory, and vestibular dysmorphogenesis in the homozygous mouse insertional mutant Tg9257. J Craniofac Genet Dev Biol. 19:157–163. 1999.PubMed/NCBI

91 

Kawamoto K, Oh SH, Kanzaki S, Brown N and Raphael Y: The functional and structural outcome of inner ear gene transfer via the vestibular and cochlear fluids in mice. Mol Ther. 4:575–585. 2001. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xia L and Yin S: Local gene transfection in the cochlea (Review). Mol Med Rep 8: 3-10, 2013.
APA
Xia, L., & Yin, S. (2013). Local gene transfection in the cochlea (Review). Molecular Medicine Reports, 8, 3-10. https://doi.org/10.3892/mmr.2013.1496
MLA
Xia, L., Yin, S."Local gene transfection in the cochlea (Review)". Molecular Medicine Reports 8.1 (2013): 3-10.
Chicago
Xia, L., Yin, S."Local gene transfection in the cochlea (Review)". Molecular Medicine Reports 8, no. 1 (2013): 3-10. https://doi.org/10.3892/mmr.2013.1496
Copy and paste a formatted citation
x
Spandidos Publications style
Xia L and Yin S: Local gene transfection in the cochlea (Review). Mol Med Rep 8: 3-10, 2013.
APA
Xia, L., & Yin, S. (2013). Local gene transfection in the cochlea (Review). Molecular Medicine Reports, 8, 3-10. https://doi.org/10.3892/mmr.2013.1496
MLA
Xia, L., Yin, S."Local gene transfection in the cochlea (Review)". Molecular Medicine Reports 8.1 (2013): 3-10.
Chicago
Xia, L., Yin, S."Local gene transfection in the cochlea (Review)". Molecular Medicine Reports 8, no. 1 (2013): 3-10. https://doi.org/10.3892/mmr.2013.1496
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