Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
July 2013 Volume 8 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July 2013 Volume 8 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Use of data mining to determine changes in the gene expression profiles of rat embryos following prenatal exposure to inflammatory stimulants

  • Authors:
    • Jianzhi Zhou
    • Xingxing Zhang
    • Haigang Zhang
    • Yi Jia
    • Ya Liu
    • Yuan Tang
    • Xiaohui Li
  • View Affiliations / Copyright

    Affiliations: Institute of Materia Medical, College of Pharmacy, Third Military Medical University, Chongqing 400038, P.R. China
  • Pages: 95-102
    |
    Published online on: May 29, 2013
       https://doi.org/10.3892/mmr.2013.1498
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Numerous clinical epidemiology and laboratory studies have demonstrated a close association between inflammation or immunity and the occurrence of hypertension. Our group has previously shown that upon intraperitoneal injection of lipopolysaccharide (LPS) or zymosan (Zym) into pregnant rats, the offspring of the experimental group exhibited higher blood pressure levels compared with the control group, and these may be associated with the effects of an accumulation of gene expression changes on female rats during pregnancy. The present study used the Affymetrix GeneChip® Rat Genome 230 2.0 Array to examine gene expression profile changes in the embryos of experimental pregnant rats intraperitoneally injected with LPS or Zym vs. the untreated controls. We discovered that genes associated with DNA replication and mRNA processing were significantly upregulated by the stimuli from analysis using GenMAPP. By contrast, genes involved in the calcium regulatory pathway in cardiac myocytes and the signaling pathway in smooth muscle contraction and relaxation were the most downregulated. Results of the microarray analysis showed that immuno-inflammatory stimuli during pregnancy affected the gene expression profiles of the embryos. These changes in gene expression may affect the developmental and metabolic status of the offspring, thereby increasing their susceptibility to hypertension and obesity.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

McMillen IC and Robinson JS: Developmental origins of the metabolic syndrome: prediction, plasticity, and programming. Physiol Rev. 85:571–633. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Barker DJ: The developmental origins of chronic adult disease. Acta Paediatr Suppl. 93:26–33. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Gluckman PD, Lillycrop KA, Vickers MH, Pleasants AB, Phillips ES, et al: Metabolic plasticity during mammalian development is directionally dependent on early nutritional status. Proc Natl Acad Sci USA. 104:12796–12800. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Johnson AD, Newton CC, Chasman DI, Ehret GB, Johnson T, et al; Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium; Global BPgen Consortium; Women’s Genome Health Study. Association of hypertension drug target genes with blood pressure and hypertension in 86,588 individuals. Hypertension. 57:903–910. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Lima SG, Hatagima A and Silva NL: Renin-angiotensin system: is it possible to identify hypertension susceptibility genes? Arq Bras Cardiol. 89:427–433. 2007.PubMed/NCBI

6 

Marcano AC, Onipinla AK, Caulfield MJ and Munroe PB: Recent advances in the identification of genes for human hypertension. Expert Rev Cardiovasc Ther. 3:733–741. 2005. View Article : Google Scholar : PubMed/NCBI

7 

McBride MW, Graham D, Delles C and Dominiczak AF: Functional genomics in hypertension. Curr Opin Nephrol Hypertens. 15:145–151. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Bautista LE, Vera LM, Arenas IA and Gamarra G: Independent association between inflammatory markers (C-reactive protein, interleukin-6, and TNF-α) and essential hypertension. J Hum Hypertens. 19:149–154. 2005.

9 

Sesso HD, Buring JE, Rifai N, Blake GJ, Gaziano JM and Ridker PM: C-reactive protein and the risk of developing hypertension. JAMA. 290:2945–2951. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Parissis JT, Korovesis S, Giazitzoglou E, Kalivas P and Katritsis D: Plasma profiles of peripheral monocyte-related inflammatory markers in patients with arterial hypertension. Correlations with plasma endothelin-1. Int J Cardiol. 83:13–21. 2002. View Article : Google Scholar

11 

Samuelsson AM, Ohrn I, Dahlgren J, Eriksson E, Angelin B, et al: Prenatal exposure to interleukin-6 results in hypertension and increased hypothalamic-pituitary-adrenal axis activity in adult rats. Endocrinology. 145:4897–4911. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Samuelsson AM, Jennische E, Hansson HA and Holmäng A: Prenatal exposure to interleukin-6 results in inflammatory neurodegeneration in hippocampus with NMDA/GABA(A) dysregulation and impaired spatial learning. Am J Physiol Regul Integr Comp Physiol. 290:R1345–R1356. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Pauletto P and Rattazzi M: Inflammation and hypertension: the search for a link. Nephrol Dial Transplant. 21:850–853. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Wei YL, Li XH and Zhou JZ: Prenatal exposure to lipopolysaccharide results in increases in blood pressure and body weight in rats. Acta Pharmacol Sin. 28:651–656. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Liao W, Wei Y, Yu C, Zhou J, Li S, et al: Prenatal exposure to zymosan results in hypertension in adult offspring rats. Clin Exp Pharmacol Physiol. 35:1413–1418. 2008.PubMed/NCBI

16 

Hao XQ, Zhang HG, Yuan ZB, Yang DL, Hao LY, et al: Prenatal exposure to lipopolysaccharide alters the intrarenal renin-angiotensin system and renal damage in offspring rats. Hypertens Res. 33:76–82. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Hao XQ, Zhang HG, Li SH, Jia Y, Liu Y, et al: Prenatal exposure to inflammation induced by zymosan results in activation of intrarenal renin-angiotensin system in adult offspring rats. Inflammation. 33:408–414. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, et al: Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet. 25:25–29. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Zhou X and Su Z: EasyGO: Gene Ontology-based annotation and functional enrichment analysis tool for agronomical species. BMC Genomics. 8:2462007. View Article : Google Scholar : PubMed/NCBI

20 

Alam-Faruque Y, Huntley RP, Khodiyar VK, Camon EB, Dimmer EC, et al: The impact of focused Gene Ontology curation of specific mammalian systems. PLoS One. 6:e275412011. View Article : Google Scholar : PubMed/NCBI

21 

Dahlquist KD, Salomonis N, Vranizan K, Lawlor SC and Conklin BR: GenMAPP, a new tool for viewing and analyzing microarray data on biological pathways. Nat Genet. 31:19–20. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Salomonis N, Hanspers K, Zambon AC, Vranizan K, Lawlor SC, et al: GenMAPP 2: new features and resources for pathway analysis. BMC Bioinformatics. 8:2172007.PubMed/NCBI

23 

Doniger SW, Salomonis N, Dahlquist KD, Vranizan K, Lawlor SC and Conklin BR: MAPPFinder: using Gene Ontology and GenMAPP to create a global gene-expression profile from microarray data. Genome Biol. 4:R72003. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhou J, Zhang X, Zhang H, Jia Y, Liu Y, Tang Y and Li X: Use of data mining to determine changes in the gene expression profiles of rat embryos following prenatal exposure to inflammatory stimulants. Mol Med Rep 8: 95-102, 2013.
APA
Zhou, J., Zhang, X., Zhang, H., Jia, Y., Liu, Y., Tang, Y., & Li, X. (2013). Use of data mining to determine changes in the gene expression profiles of rat embryos following prenatal exposure to inflammatory stimulants. Molecular Medicine Reports, 8, 95-102. https://doi.org/10.3892/mmr.2013.1498
MLA
Zhou, J., Zhang, X., Zhang, H., Jia, Y., Liu, Y., Tang, Y., Li, X."Use of data mining to determine changes in the gene expression profiles of rat embryos following prenatal exposure to inflammatory stimulants". Molecular Medicine Reports 8.1 (2013): 95-102.
Chicago
Zhou, J., Zhang, X., Zhang, H., Jia, Y., Liu, Y., Tang, Y., Li, X."Use of data mining to determine changes in the gene expression profiles of rat embryos following prenatal exposure to inflammatory stimulants". Molecular Medicine Reports 8, no. 1 (2013): 95-102. https://doi.org/10.3892/mmr.2013.1498
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou J, Zhang X, Zhang H, Jia Y, Liu Y, Tang Y and Li X: Use of data mining to determine changes in the gene expression profiles of rat embryos following prenatal exposure to inflammatory stimulants. Mol Med Rep 8: 95-102, 2013.
APA
Zhou, J., Zhang, X., Zhang, H., Jia, Y., Liu, Y., Tang, Y., & Li, X. (2013). Use of data mining to determine changes in the gene expression profiles of rat embryos following prenatal exposure to inflammatory stimulants. Molecular Medicine Reports, 8, 95-102. https://doi.org/10.3892/mmr.2013.1498
MLA
Zhou, J., Zhang, X., Zhang, H., Jia, Y., Liu, Y., Tang, Y., Li, X."Use of data mining to determine changes in the gene expression profiles of rat embryos following prenatal exposure to inflammatory stimulants". Molecular Medicine Reports 8.1 (2013): 95-102.
Chicago
Zhou, J., Zhang, X., Zhang, H., Jia, Y., Liu, Y., Tang, Y., Li, X."Use of data mining to determine changes in the gene expression profiles of rat embryos following prenatal exposure to inflammatory stimulants". Molecular Medicine Reports 8, no. 1 (2013): 95-102. https://doi.org/10.3892/mmr.2013.1498
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team