Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
September 2013 Volume 8 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September 2013 Volume 8 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Lack of effect of common single nucleotide polymorphisms in leukotriene pathway genes on platelet reactivity in patients with diabetes

  • Authors:
    • Marek Rosiak
    • Marek Postula
    • Agnieszka Kaplon‑Cieslicka
    • Agnieszka Kondracka
    • Ewa Trzepla
    • Malgorzata Zaremba
    • Krzysztof J. Filipiak
    • Dariusz A. Kosior
    • Andrzej Czlonkowski
    • Grzegorz Opolski
    • Piotr K. Janicki
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Medical University of Warsaw, Warsaw 02‑927, Poland, Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw 02‑927, Poland, Department of Internal Medicine and Endocrinology, Medical University of Warsaw, Warsaw 02‑927, Poland, Department of Noninvasive Cardiology and Hypertension, Central Clinical Hospital, The Ministry of the Interior, Warsaw 02‑507, Poland, Perioperative Genomics Laboratory, Department of Anesthesiology, Penn State College of Medicine, Hershey, Pennsylvania 17033‑0850, USA
  • Pages: 853-860
    |
    Published online on: July 3, 2013
       https://doi.org/10.3892/mmr.2013.1567
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to investigate the effect of genetic polymorphisms in candidate genes within the leukotriene (LT) pathway on platelet reactivity and the concentration of selected LTs in diabetic patients treated with acetylsalicylic acid (ASA). The study cohort consisted of 287 Caucasians with type 2 diabetes who had received treatment with ASA tablets (75 mg/day) for at least three months. Platelet reactivity analyses were performed using VerifyNow aspirin and PFA‑100 assays. The measured LTs included leukotriene B4 (LTB4) and leukotriene E4 (LTE4). Genotyping for the selected 25 single nucleotide polymorphisms (SNPs) within six genes of the LT pathway was performed using a Sequenom iPLEX platform. No statistically significant association was observed between the investigated SNP genotypes, platelet reactivity and measured LTs in the patient cohort. The results of our study suggest that certain polymorphisms of the LT pathway are not associated with altered platelet reactivity and the measured LTs in diabetic patients treated with ASA.
View Figures

Figure 1

View References

1 

Mortensen SB, Larsen SB, Grove EL, Kristensen SD and Hvas AM: Reduced platelet response to aspirin in patients with coronary artery disease and type 2 diabetes mellitus. Thromb Res. 126:e318–e322. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Evangelista V, de Berardis G, Totani L, et al: Persistent platelet activation in patients with type 2 diabetes treated with low doses of aspirin. J Thromb Haemost. 5:2197–2203. 2007. View Article : Google Scholar : PubMed/NCBI

3 

DiChiara J, Bliden KP, Tantry US, et al: The effect of aspirin dosing on platelet function in diabetic and nondiabetic patients: an analysis from the aspirin-induced platelet effect (ASPECT) study. Diabetes. 56:3014–3019. 2007. View Article : Google Scholar

4 

Martel-Pelletier J, Lajeunesse D, Reboul P and Pelletier JP: Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs. Ann Rheum Dis. 62:501–509. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Peters-Golden M and Henderson WR Jr: Leukotrienes. N Engl J Med. 357:1841–1854. 2007. View Article : Google Scholar

6 

Johnson AD: The genetics of common variation affecting platelet development, function and pharmaceutical targeting. J Thromb Haemost. 9:246–257. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Postula M, Kaplon-Cieslicka A, Rosiak M, et al: Genetic determinants of platelet reactivity during acetylsalicylic acid therapy in diabetic patients: evaluation of 27 polymorphisms within candidate genes. J Thromb Haemost. 9:2291–2301. 2011. View Article : Google Scholar

8 

Nielsen HL, Kristensen SD, Thygesen SS, et al: Aspirin response evaluated by the VerifyNow Aspirin System and light transmission aggregometry. Thromb Res. 123:267–273. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Postula M, Janicki PK, Rosiak M, et al: New single nucleotide polymorphisms associated with differences in platelets reactivity in patients with type 2 diabetes treated with acetylsalicylic acid: genome-wide association approach and pooled DNA strategy. J Thromb Thrombolysis. 36:65–73. 2013. View Article : Google Scholar

10 

Renda G, Zurro M, Malatesta G, Ruggieri B and De Caterina R: Inconsistency of different methods for assessing ex vivo platelet function: relevance for the detection of aspirin resistance. Haematologica. 95:2095–2101. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Rosiak M, Postula M, Kaplon-Cieslicka A, et al: The effect of doubling the dose of acetylsalicylic acid (ASA) on platelet function parameters in patients with type 2 diabetes and platelet hyperreactivity during treatment with 75 mg of ASA: a subanalysis of the AVOCADO study. Kardiol Pol. 71(6): 552–557. 2013.PubMed/NCBI

12 

Kunicki TJ, Williams SA, Salomon DR, et al: Genetics of platelet reactivity in normal, healthy individuals. J Thromb Haemost. 7:2116–2122. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Chakroun T, Addad F, Abderazek F, et al: Screening for aspirin resistance in stable coronary artery patients by three different tests. Thromb Res. 121:413–418. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Gonzalez-Conejero R, Rivera J, Corral J, Acuña C, Guerrero JA and Vicente V: Biological assessment of aspirin efficacy on healthy individuals: heterogeneous response or aspirin failure? Stroke. 36:276–280. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Zhang K, Wang YY, Liu QJ, et al: Two single nucleotide polymorphisms in ALOX15 are associated with risk of coronary artery disease in a Chinese Han population. Heart Vessels. 25:368–373. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Zhao J, He Z, Ma S and Li L: Association of ALOX15 gene polymorphism with ischemic stroke in Northern Chinese Han population. J Mol Neurosci. 47:458–464. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Helgadottir A, Gretarsdottir S, St Clair D, et al: Association between the gene encoding 5-lipoxygenase-activating protein and stroke replicated in a Scottish population. Am J Hum Genet. 76:505–509. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Helgadottir A, Manolescu A, Helgason A, et al: A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction. Nat Genet. 38:68–74. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Linsel-Nitschke P, Götz A, Medack A, et al: Genetic variation in the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) is associated with myocardial infarction in the German population. Clin Sci (Lond). 115:309–315. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Hartiala J, Li D, Conti DV, et al: Genetic contribution of the leukotriene pathway to coronary artery disease. Hum Genet. 129:617–627. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Werz O and Steinhilber D: Therapeutic options for 5-lipoxygenase inhibitors. Pharmacol Ther. 112:701–718. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Camacho M, Martinez-Perez A, Buil A, et al: Genetic determinants of 5-lipoxygenase pathway in a Spanish population and their relationship with cardiovascular risk. Atherosclerosis. 224:129–135. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Burdon KP, Rudock ME, Lehtinen AB, et al: Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study. Mediators Inflamm. 2010:1701532010. View Article : Google Scholar : PubMed/NCBI

24 

Crosslin DR, Shah SH, Nelson SC, et al: Genetic effects in the leukotriene biosynthesis pathway and association with atherosclerosis. Hum Genet. 125:217–229. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Girelli D, Martinelli N, Trabetti E, et al: ALOX5AP gene variants and risk of coronary artery disease: an angiography-based study. Eur J Hum Genet. 15:959–966. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Michelson AD: Methods for the measurement of platelet function. Am J Cardiol. 103:20A–26A. 2009. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Rosiak M, Postula M, Kaplon‑Cieslicka A, Kondracka A, Trzepla E, Zaremba M, Filipiak KJ, Kosior DA, Czlonkowski A, Opolski G, Opolski G, et al: Lack of effect of common single nucleotide polymorphisms in leukotriene pathway genes on platelet reactivity in patients with diabetes. Mol Med Rep 8: 853-860, 2013.
APA
Rosiak, M., Postula, M., Kaplon‑Cieslicka, A., Kondracka, A., Trzepla, E., Zaremba, M. ... Janicki, P.K. (2013). Lack of effect of common single nucleotide polymorphisms in leukotriene pathway genes on platelet reactivity in patients with diabetes. Molecular Medicine Reports, 8, 853-860. https://doi.org/10.3892/mmr.2013.1567
MLA
Rosiak, M., Postula, M., Kaplon‑Cieslicka, A., Kondracka, A., Trzepla, E., Zaremba, M., Filipiak, K. J., Kosior, D. A., Czlonkowski, A., Opolski, G., Janicki, P. K."Lack of effect of common single nucleotide polymorphisms in leukotriene pathway genes on platelet reactivity in patients with diabetes". Molecular Medicine Reports 8.3 (2013): 853-860.
Chicago
Rosiak, M., Postula, M., Kaplon‑Cieslicka, A., Kondracka, A., Trzepla, E., Zaremba, M., Filipiak, K. J., Kosior, D. A., Czlonkowski, A., Opolski, G., Janicki, P. K."Lack of effect of common single nucleotide polymorphisms in leukotriene pathway genes on platelet reactivity in patients with diabetes". Molecular Medicine Reports 8, no. 3 (2013): 853-860. https://doi.org/10.3892/mmr.2013.1567
Copy and paste a formatted citation
x
Spandidos Publications style
Rosiak M, Postula M, Kaplon‑Cieslicka A, Kondracka A, Trzepla E, Zaremba M, Filipiak KJ, Kosior DA, Czlonkowski A, Opolski G, Opolski G, et al: Lack of effect of common single nucleotide polymorphisms in leukotriene pathway genes on platelet reactivity in patients with diabetes. Mol Med Rep 8: 853-860, 2013.
APA
Rosiak, M., Postula, M., Kaplon‑Cieslicka, A., Kondracka, A., Trzepla, E., Zaremba, M. ... Janicki, P.K. (2013). Lack of effect of common single nucleotide polymorphisms in leukotriene pathway genes on platelet reactivity in patients with diabetes. Molecular Medicine Reports, 8, 853-860. https://doi.org/10.3892/mmr.2013.1567
MLA
Rosiak, M., Postula, M., Kaplon‑Cieslicka, A., Kondracka, A., Trzepla, E., Zaremba, M., Filipiak, K. J., Kosior, D. A., Czlonkowski, A., Opolski, G., Janicki, P. K."Lack of effect of common single nucleotide polymorphisms in leukotriene pathway genes on platelet reactivity in patients with diabetes". Molecular Medicine Reports 8.3 (2013): 853-860.
Chicago
Rosiak, M., Postula, M., Kaplon‑Cieslicka, A., Kondracka, A., Trzepla, E., Zaremba, M., Filipiak, K. J., Kosior, D. A., Czlonkowski, A., Opolski, G., Janicki, P. K."Lack of effect of common single nucleotide polymorphisms in leukotriene pathway genes on platelet reactivity in patients with diabetes". Molecular Medicine Reports 8, no. 3 (2013): 853-860. https://doi.org/10.3892/mmr.2013.1567
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team