Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies

  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
September 2013 Volume 8 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September 2013 Volume 8 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

No association between IRS‑1 promoter methylation and type 2 diabetes

  • Authors:
    • Jiangbo Ma
    • Jia Cheng
    • Lingyan Wang
    • Hongwei Wang
    • Leiting Xu
    • Panpan Liu
    • Shizhong Bu
    • Lina Zhang
    • Yanping Le
    • Meng Ye
    • Qinwen Wang
    • Yuping Shi
    • Shiwei Duan

  • View Affiliations / Copyright

    Affiliations: Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, P.R. China, The Affiliated Hospital, School of Medicine, Ningbo University, Ningbo, Zhejiang 315000, P.R. China, Bank of Blood Products, Ningbo No. 2 Hospital, Ningbo, Zhejiang 315010, P.R. China, Section of Endocrinology, The University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University, Ningbo, Zhejiang 315211, P.R. China, Second Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou, Zhejiang 310009, P.R. China
  • Pages: 949-953
    |
    Published online on: July 3, 2013
       https://doi.org/10.3892/mmr.2013.1569
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

As a candidate gene for type 2 diabetes (T2D), insulin receptor substrate-1 (IRS‑1) gene variations were found to be associated with the risk of T2D. The aim of our study was to investigate the contribution of promoter DNA methylation of the IRS‑1 gene to the risk of T2D. Using bisulphite pyrosequencing technology, the DNA methylation levels of 3 CpG dinucleotides within the IRS‑1 gene promoter were measured in 48 T2D patients and 48 age‑ and gender‑matched healthy controls. Our results indicated that there was no significant association between the methylation of the IRS‑1 gene promoter and the risk of T2D (P>0.1). A breakdown analysis by gender revealed that IRS‑1 promoter methylation was not associated with an increased risk of T2D for either gender (P>0.1), although there were significantly lower methy­lation levels of CpG1 (P=0.002) and CpG2 (P=0.043) within the IRS‑1 gene promoter in males than in females.
View Figures

Figure 1

View References

1 

Shaw JE, Sicree RA and Zimmet PZ: Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract. 87:4–14. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Travers ME and McCarthy MI: Type 2 diabetes and obesity: genomics and the clinic. Hum Genet. 130:41–58. 2011. View Article : Google Scholar : PubMed/NCBI

3 

McCarthy MI: Genomics, type 2 diabetes, and obesity. N Engl J Med. 363:2339–2350. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Stolar M: Glycemic control and complications in type 2 diabetes mellitus. Am J Med. 123:S3–S11. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Volkmar M, Dedeurwaerder S, Cunha DA, et al: DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients. EMBO J. 31:1405–1426. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Barres R and Zierath JR: DNA methylation in metabolic disorders. Am J Clin Nutr. 93:S897–S900. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Bird A: Perceptions of epigenetics. Nature. 447:396–398. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Villeneuve LM and Natarajan R: The role of epigenetics in the pathology of diabetic complications. Am J Physiol Renal Physiol. 299:F14–F25. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Toperoff G, Aran D, Kark JD, et al: Genome-wide survey reveals predisposing diabetes type 2-related DNA methylation variations in human peripheral blood. Hum Mol Genet. 21:371–383. 2012. View Article : Google Scholar : PubMed/NCBI

10 

White MF: IRS proteins and the common path to diabetes. Am J Physiol Endocrinol Metab. 283:E413–E422. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Angiolillo DJ, Bernardo E, Zanoni M, et al: Impact of insulin receptor substrate-1 genotypes on platelet reactivity and cardiovascular outcomes in patients with type 2 diabetes mellitus and coronary artery disease. J Am Coll Cardiol. 58:30–39. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Sesti G, Federici M, Hribal ML, et al: Defects of the insulin receptor substrate (IRS) system in human metabolic disorders. FASEB J. 15:2099–2111. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Fernandez-Valverde SL, Taft RJ and Mattick JS: MicroRNAs in β-cell biology, insulin resistance, diabetes and its complications. Diabetes. 60:1825–1831. 2011.

14 

Araki E, Lipes MA, Patti ME, et al: Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature. 372:186–190. 1994. View Article : Google Scholar : PubMed/NCBI

15 

Rondinone CM, Wang LM, Lonnroth P, et al: Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus. Proc Natl Acad Sci USA. 94:4171–4175. 1997. View Article : Google Scholar

16 

Bredfeldt TG, Greathouse KL, Safe SH, et al: Xenoestrogen- induced regulation of EZH2 and histone methylation via estrogen receptor signaling to PI3K/AKT. Mol Endocrinol. 24:993–1006. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Christensen BC, Kelsey KT, Zheng S, et al: Breast cancer DNA methylation profiles are associated with tumor size and alcohol and folate intake. PLoS Genet. 6:e10010432010. View Article : Google Scholar : PubMed/NCBI

18 

Li L, Lee KM, Han W, et al: Estrogen and progesterone receptor status affect genome-wide DNA methylation profile in breast cancer. Hum Mol Genet. 19:4273–4277. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Starlard-Davenport A, Tryndyak VP, James SR, et al: Mechanisms of epigenetic silencing of the Rassf1a gene during estrogen-induced breast carcinogenesis in ACI rats. Carcinogenesis. 31:376–381. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Ng SF, Lin RC, Laybutt DR, et al: Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring. Nature. 467:963–966. 2010.

21 

Martinez-Gomez LE, Cruz M, Martinez-Nava GA, et al: A replication study of the IRS1, CAPN10, TCF7L2, and PPARG gene polymorphisms associated with type 2 diabetes in two different populations of Mexico. Ann Hum Genet. 75:612–620. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Zhang J, Du YY, Lin YF, et al: The cell growth suppressor, mir-126, targets IRS-1. Biochem Biophys Res Commun. 377:136–140. 2008. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ma J, Cheng J, Wang L, Wang H, Xu L, Liu P, Bu S, Zhang L, Le Y, Ye M, Ye M, et al: No association between IRS‑1 promoter methylation and type 2 diabetes. Mol Med Rep 8: 949-953, 2013.
APA
Ma, J., Cheng, J., Wang, L., Wang, H., Xu, L., Liu, P. ... Duan, S. (2013). No association between IRS‑1 promoter methylation and type 2 diabetes. Molecular Medicine Reports, 8, 949-953. https://doi.org/10.3892/mmr.2013.1569
MLA
Ma, J., Cheng, J., Wang, L., Wang, H., Xu, L., Liu, P., Bu, S., Zhang, L., Le, Y., Ye, M., Wang, Q., Shi, Y., Duan, S."No association between IRS‑1 promoter methylation and type 2 diabetes". Molecular Medicine Reports 8.3 (2013): 949-953.
Chicago
Ma, J., Cheng, J., Wang, L., Wang, H., Xu, L., Liu, P., Bu, S., Zhang, L., Le, Y., Ye, M., Wang, Q., Shi, Y., Duan, S."No association between IRS‑1 promoter methylation and type 2 diabetes". Molecular Medicine Reports 8, no. 3 (2013): 949-953. https://doi.org/10.3892/mmr.2013.1569
Copy and paste a formatted citation
x
Spandidos Publications style
Ma J, Cheng J, Wang L, Wang H, Xu L, Liu P, Bu S, Zhang L, Le Y, Ye M, Ye M, et al: No association between IRS‑1 promoter methylation and type 2 diabetes. Mol Med Rep 8: 949-953, 2013.
APA
Ma, J., Cheng, J., Wang, L., Wang, H., Xu, L., Liu, P. ... Duan, S. (2013). No association between IRS‑1 promoter methylation and type 2 diabetes. Molecular Medicine Reports, 8, 949-953. https://doi.org/10.3892/mmr.2013.1569
MLA
Ma, J., Cheng, J., Wang, L., Wang, H., Xu, L., Liu, P., Bu, S., Zhang, L., Le, Y., Ye, M., Wang, Q., Shi, Y., Duan, S."No association between IRS‑1 promoter methylation and type 2 diabetes". Molecular Medicine Reports 8.3 (2013): 949-953.
Chicago
Ma, J., Cheng, J., Wang, L., Wang, H., Xu, L., Liu, P., Bu, S., Zhang, L., Le, Y., Ye, M., Wang, Q., Shi, Y., Duan, S."No association between IRS‑1 promoter methylation and type 2 diabetes". Molecular Medicine Reports 8, no. 3 (2013): 949-953. https://doi.org/10.3892/mmr.2013.1569
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team