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Article

Protective effect of the herbal medicine Gan‑fu‑kang against carbon tetrachloride‑induced liver fibrosis in rats

  • Authors:
    • Caihua Zhang
    • Yanfu Wang
    • Hong Chen
    • Guang Yang
    • Shaopeng Wang
    • Miaona Jiang
    • Li Cong
    • Lijun Yuan
    • Hanshu Li
    • Yujie Jia
  • View Affiliations / Copyright

    Affiliations: Department of Pathophysiology, Dalian Medical University, Dalian, Liaoning 116044, P.R. China, The First Affiliated Hospital, Dalian Medical University, Dalian, Liaoning 116011, P.R. China
  • Pages: 954-962
    |
    Published online on: July 12, 2013
       https://doi.org/10.3892/mmr.2013.1587
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Abstract

The aim of the present study was to investigate the effect of a herbal medicine formula, Gan‑fu‑kang (GFK), on the treatment of liver fibrosis in rats and the mechanisms via which it exerts its effect. Liver fibrosis was induced in rats by subcutaneous injection of carbon tetrachloride (CCl4) at 0.5 mg/kg body weight, twice a week for 8 weeks. The rats were randomly selected to receive saline or GFK at 31.25, 312.5 or 3,125 mg/kg body weight/day between weeks 9 and 20. An additional group of rats without CCl4 injection was used as the baseline. In the liver fibrosis model rats, an increase in plasma liver enzymes, fibrotic markers in serum and liver fibrosis, production of α‑smooth muscle actin, matrix metalloproteinase‑2 and tissue inhibitor of metalloproteinase‑1, synthesis of collagen and activation of the Wnt/β‑catenin signaling pathway were observed. GFK administration was found to significantly reduce these changes. Results of this study demonstrate that GFK has a protective and therapeutic effect on liver fibrosis induced by CCl4, which may be associated with its inhibitory activity on HSC proliferation and collagen synthesis, effectively downregulating Wnt/β‑catenin signaling.
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View References

1 

Friedman SL: Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem. 275:2247–2250. 2000. View Article : Google Scholar : PubMed/NCBI

2 

Cheng M and Yang C: The Basic Study and Clinical Research on Hepatic Fibrosis. First edition. First Jumbo Publishing Co; California, USA: 2002

3 

Moreira RK: Hepatic stellate cells and liver fibrosis. Arch Pathol Lab Med. 131:1728–1734. 2007.PubMed/NCBI

4 

Wu J and Zern MA: Hepatic stellate cells: a target for the treatment of liver fibrosis. J Gastroenterol. 35:665–672. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Mann J and Mann DA: Transcriptional regulation of hepatic stellate cells. Adv Drug Deliv Rev. 61:497–512. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Gäbele E, Brenner DA and Rippe RA: Liver fibrosis: signals leading to the amplification of the fibrogenic hepatic stellate cell. Front Biosci. 8:d69–d77. 2003.PubMed/NCBI

7 

Zou YH, Yang Y, Li J, et al: Potential therapeutic effects of a traditional Chinese formulation, BJ-JN, on liver fibrosis induced by carbon tetrachloride in rats. J Ethnopharmacol. 120:452–457. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Purps O, Lahme B, Gressner AM, Meindl-Beinker NM and Dooley S: Loss of TGF-beta dependent growth control during HSC transdifferentiation. Biochem Biophys Res Commun. 353:841–847. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Borkham-Kamphorst E, van Roeyen CR, Ostendorf T, Floege J, Gressner AM and Weiskirchen R: Pro-fibrogenic potential of PDGF-D in liver fibrosis. J Hepatol. 46:1064–1074. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Brewster UC, Setaro JF and Perazella MA: The renin-angiotensin-aldosterone system: cardiorenal effects and implications for renal and cardiovascular disease states. Am J Med Sci. 326:15–24. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Cadigan KM and Nusse R: Wnt signaling: a common theme in animal development. Genes Dev. 11:3286–3305. 1997. View Article : Google Scholar : PubMed/NCBI

12 

Lin X, Zhang S, Huang Q, et al: Protective effect of Fufang-Liu-Yue-Qing, a traditional Chinese herbal formula, on CCl4 induced liver fibrosis in rats. J Ethnopharmacol. 142:548–556. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Xu TT, Jiang MN, Li C, Che Y and Jia YJ: Effect of Chinese traditional compound, Gan-fu-kang, on CCl(4)-induced liver fibrosis in rats and its probable molecular mechanisms. Hepatol Res. 37:221–229. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Gao Y, Song LX, Jiang MN, Ge GY and Jia YJ: Effects of traditional chinese medicine on endotoxin and its receptors in rats with non-alcoholic steatohepatitis. Inflammation. 31:121–132. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Lee PN, Pang K, Matus DQ and Martindale MQ: A WNT of things to come: evolution of Wnt signaling and polarity in cnidarians. Semin Cell Dev Biol. 17:157–167. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Zhao J, Kim KA and Abo A: Tipping the balance: modulating the Wnt pathway for tissue repair. Trends Biotechnol. 27:131–136. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Lustig B and Behrens J: The Wnt signaling pathway and its role in tumor development. J Cancer Res Clin Oncol. 129:199–221. 2003.PubMed/NCBI

18 

Kikuchi A and Yamamoto H: Tumor formation due to abnormalities in the β-catenin-independent pathway of Wnt signaling. Cancer Sci. 99:202–208. 2008.

19 

Zhang B, Zhou KK and Ma JX: Inhibition of connective tissue growth factor overexpression in diabetic retinopathy by SERPINA3K via blocking the WNT/beta-catenin pathway. Diabetes. 59:1809–1816. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Morrisey EE: Wnt signaling and pulmonary fibrosis. Am J Pathol. 162:1393–1397. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Habas R and Dawid IB: Dishevelled and Wnt signaling: is the nucleus the final frontier? J Biol. 4:22005. View Article : Google Scholar : PubMed/NCBI

22 

Logan CY and Nusse R: The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol. 20:781–810. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Ross SE, Hemati N, Longo KA, Bennett CN, Lucas PC, Erickson RL and MacDougald OA: Inhibition of adipogenesis by Wnt signaling. Science. 289:950–953. 2000. View Article : Google Scholar : PubMed/NCBI

24 

Cheng JH, She H, Han YP, et al: Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis. Am J Physiol Gastrointest Liver Physiol. 294:G39–G49. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Lou JL, Jiang MN, Li C, et al: Herb medicine Gan-fu-kang attenuates liver injury in a rat fibrotic model. J Ethnopharmacol. 128:131–138. 2010. View Article : Google Scholar : PubMed/NCBI

26 

National Institutes of Health. Guide for the Care and Use of Laboratory Animals. Sixth edition. National Acadamies Press; Washington, D.C: 1985

27 

Nie QH, Cheng YQ, Xie YM, Zhou YX and Cao YZ: Inhibiting effect of antisense oligonucleotides phosphorthioate on gene expression of TIMP-1 in rat liver fibrosis. World J Gastroenterol. 7:363–369. 2001.PubMed/NCBI

28 

Dignani JD, Lebovitz RM and Roeder RG: Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475–1489. 1983. View Article : Google Scholar : PubMed/NCBI

29 

Castera L: Assessing liver fibrosis. Expert Rev Gastroenterol Hepatol. 2:541–552. 2008. View Article : Google Scholar

30 

Faria SC, Ganesan K, Mwangi I, et al: MR imaging of liver fibrosis: current state of the art. Radiographics. 29:1615–1635. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Watson MR, Wallace K, Gieling RG, et al: NF-kappaB is a critical regulator of the survival of rodent and human hepatic myofibroblasts. J Hepatol. 48:589–597. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Tsukada S, Parsons CJ and Rippe RA: Mechanisms of liver fibrosis. Clin Chim Acta. 364:33–60. 2006. View Article : Google Scholar

33 

Friedman SL: Liver fibrosis-from bench to bedside. J Hepatol. 38:S38–S53. 2003. View Article : Google Scholar

34 

Fowell AJ and Iredale JP: Emerging therapies for liver fibrosis. Dig Dis. 24:174–183. 2006. View Article : Google Scholar : PubMed/NCBI

35 

Sturgill MG and Lambert GH: Xenobiotic-induced hepatotoxicity: mechanisms of liver injury and methods of monitoring hepatic function. Clin Chem. 43:1512–1526. 1997.PubMed/NCBI

36 

Achliya GS, Wadodkar SG and Dorle AK: Evaluation of hepatoprotective effect of Amalkadi Ghrita against carbon tetrachloride-induced hepatic damage in rats. J Ethnopharmacol. 90:229–232. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Leroy V: Other non-invasive markers of liver fibrosis. Gastroenterol Clin Biol. 32(6 Suppl 1): 52–57. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Bataller R and Brenner DA: Liver fibrosis. J Clin Invest. 115:209–218. 2005. View Article : Google Scholar

39 

Lotersztajn S, Julien B, Teixeira-Clerc F, Grenard P and Mallat A: Hepatic fibrosis: molecular mechanisms and drug targets. Annu Rev Pharmacol Toxicol. 45:605–628. 2005. View Article : Google Scholar : PubMed/NCBI

40 

Li D and Friedman SL: Liver fibrogenesis and the role of hepatic stellate cells: new insights and prospects for therapy. J Gastroenterol Hepatol. 14:618–633. 1999. View Article : Google Scholar : PubMed/NCBI

41 

Han YP: Matrix metalloproteinases, the pros and cons, in liver fibrosis. J Gastroenterol Hepatol. 21(Suppl 3): S88–S91. 2006. View Article : Google Scholar : PubMed/NCBI

42 

Lichtinghagen R, Michels D, Haberkorn CI, et al: Matrix metalloproteinase (MMP)-2, MMP-7 and tissue inhibitor of metalloproteinase-1 are closely related to the fibroproliferative process in the liver during chronic hepatitis C. J Hepatol. 34:239–247. 2001. View Article : Google Scholar : PubMed/NCBI

43 

Arthur MJ, Mann DA and Iredale JP: Tissue inhibitors of metalloproteinases, hepatic stellate cells and liver fibrosis. J Gastroenterol Hepatol. 13:S33–S38. 1998.PubMed/NCBI

44 

Clevers H: Wnt/beta-catenin signaling in development and disease. Cell. 127:469–480. 2006. View Article : Google Scholar : PubMed/NCBI

45 

Chilosi M, Poletti V, Zamò A, et al: Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis. Am J Pathol. 162:1495–1502. 2003. View Article : Google Scholar : PubMed/NCBI

46 

Königshoff M, Balsara N, Pfaff EM, et al: Functional Wnt signaling is increased in idiopathic pulmonary fibrosis. PLoS One. 3:e21422008.PubMed/NCBI

47 

Luk JM, Wang X, Liu P, et al: Traditional Chinese herbal medicines for treatment of liver fibrosis and cancer: from laboratory discovery to clinical evaluation. Liver Int. 27:879–890. 2007. View Article : Google Scholar : PubMed/NCBI

48 

He W, Dai C, Li Y, Zeng G, Monga SP and Liu Y: Wnt/beta-catenin signaling promotes renal interstitial fibrosis. J Am Soc Nephrol. 20:765–776. 2009. View Article : Google Scholar : PubMed/NCBI

49 

Brack AS, Conboy MJ, Roy S, et al: Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. Science. 317:807–810. 2007. View Article : Google Scholar : PubMed/NCBI

50 

Jiang F, Parsons CJ and Stefanovic B: Gene expression profile of quiescent and activated rat hepatic stellate cells implicates Wnt signaling pathway in activation. J Hepatol. 45:401–409. 2006. View Article : Google Scholar : PubMed/NCBI

51 

Myung SJ, Yoon JH, Gwak GY, et al: Wnt signaling enhances the activation and survival of human hepatic stellate cells. FEBS Lett. 581:2954–2958. 2007. View Article : Google Scholar : PubMed/NCBI

52 

Kordes C, Sawitza I and Häussinger D: Canonical Wnt signaling maintains the quiescent stage of hepatic stellate cells. Biochem Biophys Res Commun. 367:116–123. 2008. View Article : Google Scholar : PubMed/NCBI

53 

MacDonald BT, Tamai K and He X: Wnt/beta-catenin signaling: components, mechanisms and diseases. Dev Cell. 17:9–26. 2009. View Article : Google Scholar : PubMed/NCBI

54 

Ying J, Li H, Yu J, et al: WNT5A exhibits tumor-suppressive activity through antagonizing the Wnt/beta-catenin signaling, and is frequently methylated in colorectal cancer. Clin Cancer Res. 14:55–61. 2008. View Article : Google Scholar : PubMed/NCBI

55 

Albrecht JH and Hansen LK: Cyclin D1 promotes mitogen-independent cell cycle progression in hepatocytes. Cell Growth Differ. 10:397–404. 1999.PubMed/NCBI

56 

Houseknecht KL, Cole BM and Steele PJ: Peroxisome proliferator-activated receptor gamma (PPARgamma) and its ligands: a review. Domest Anim Endocrinol. 22:1–23. 2002. View Article : Google Scholar : PubMed/NCBI

57 

Galli A, Crabb DW, Ceni E, et al: Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro. Gastroenterology. 122:1924–1940. 2002. View Article : Google Scholar : PubMed/NCBI

58 

Liu J and Farmer SR: Regulating the balance between peroxisome proliferator-activated receptor gamma and beta-catenin signaling during adipogenesis. A glycogen synthase kinase 3beta phosphorylation-defective mutant of beta-catenin inhibits expression of a subset of adipogenic genes. J Biol Chem. 279:45020–45027. 2004.

59 

Moldes M, Zuo Y, Morrison RF, et al: Peroxisome-proliferator-activated receptor gamma suppresses Wnt/betacatenin signalling during adipogenesis. Biochem J. 376:607–613. 2003. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang C, Wang Y, Chen H, Yang G, Wang S, Jiang M, Cong L, Yuan L, Li H, Jia Y, Jia Y, et al: Protective effect of the herbal medicine Gan‑fu‑kang against carbon tetrachloride‑induced liver fibrosis in rats. Mol Med Rep 8: 954-962, 2013.
APA
Zhang, C., Wang, Y., Chen, H., Yang, G., Wang, S., Jiang, M. ... Jia, Y. (2013). Protective effect of the herbal medicine Gan‑fu‑kang against carbon tetrachloride‑induced liver fibrosis in rats. Molecular Medicine Reports, 8, 954-962. https://doi.org/10.3892/mmr.2013.1587
MLA
Zhang, C., Wang, Y., Chen, H., Yang, G., Wang, S., Jiang, M., Cong, L., Yuan, L., Li, H., Jia, Y."Protective effect of the herbal medicine Gan‑fu‑kang against carbon tetrachloride‑induced liver fibrosis in rats". Molecular Medicine Reports 8.3 (2013): 954-962.
Chicago
Zhang, C., Wang, Y., Chen, H., Yang, G., Wang, S., Jiang, M., Cong, L., Yuan, L., Li, H., Jia, Y."Protective effect of the herbal medicine Gan‑fu‑kang against carbon tetrachloride‑induced liver fibrosis in rats". Molecular Medicine Reports 8, no. 3 (2013): 954-962. https://doi.org/10.3892/mmr.2013.1587
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang C, Wang Y, Chen H, Yang G, Wang S, Jiang M, Cong L, Yuan L, Li H, Jia Y, Jia Y, et al: Protective effect of the herbal medicine Gan‑fu‑kang against carbon tetrachloride‑induced liver fibrosis in rats. Mol Med Rep 8: 954-962, 2013.
APA
Zhang, C., Wang, Y., Chen, H., Yang, G., Wang, S., Jiang, M. ... Jia, Y. (2013). Protective effect of the herbal medicine Gan‑fu‑kang against carbon tetrachloride‑induced liver fibrosis in rats. Molecular Medicine Reports, 8, 954-962. https://doi.org/10.3892/mmr.2013.1587
MLA
Zhang, C., Wang, Y., Chen, H., Yang, G., Wang, S., Jiang, M., Cong, L., Yuan, L., Li, H., Jia, Y."Protective effect of the herbal medicine Gan‑fu‑kang against carbon tetrachloride‑induced liver fibrosis in rats". Molecular Medicine Reports 8.3 (2013): 954-962.
Chicago
Zhang, C., Wang, Y., Chen, H., Yang, G., Wang, S., Jiang, M., Cong, L., Yuan, L., Li, H., Jia, Y."Protective effect of the herbal medicine Gan‑fu‑kang against carbon tetrachloride‑induced liver fibrosis in rats". Molecular Medicine Reports 8, no. 3 (2013): 954-962. https://doi.org/10.3892/mmr.2013.1587
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