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Article

Role of microRNAs in chronic lymphocytic leukemia (Review)

  • Authors:
    • Xiang-Xiang Zhou
    • Xin Wang
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China
  • Pages: 719-725
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    Published online on: July 23, 2013
       https://doi.org/10.3892/mmr.2013.1599
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Abstract

Chronic lymphocytic leukemia (CLL) is the most common type of leukemia among adults in the western world. It is characterized by a malignant clone of B cells in the bone marrow, blood and secondary lymphoid tissues. microRNAs (miRNAs) are a family of small, non‑coding RNAs that regulate the expression of target messenger RNAs at the post‑transcriptional level. Previous studies have suggested that miRNAs are extensively involved in the proliferation and differentiation of hematopoietic cells. Aberrant expression of certain miRNAs has been observed in CLL. Associations between miRNAs and chromosomal abnormalities suggest that miRNAs may be involved in the pathogenesis of CLL. Moreover, miRNAs may be used as novel biomarkers for the prognosis of CLL. Expression levels of miRNAs are also involved in resistance to chemotherapy drugs. In this article, we review recent developments of miRNAs in the initiation, prognosis and chemoresistance of CLL.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou X and Wang X: Role of microRNAs in chronic lymphocytic leukemia (Review) . Mol Med Rep 8: 719-725, 2013.
APA
Zhou, X., & Wang, X. (2013). Role of microRNAs in chronic lymphocytic leukemia (Review) . Molecular Medicine Reports, 8, 719-725. https://doi.org/10.3892/mmr.2013.1599
MLA
Zhou, X., Wang, X."Role of microRNAs in chronic lymphocytic leukemia (Review) ". Molecular Medicine Reports 8.3 (2013): 719-725.
Chicago
Zhou, X., Wang, X."Role of microRNAs in chronic lymphocytic leukemia (Review) ". Molecular Medicine Reports 8, no. 3 (2013): 719-725. https://doi.org/10.3892/mmr.2013.1599
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou X and Wang X: Role of microRNAs in chronic lymphocytic leukemia (Review) . Mol Med Rep 8: 719-725, 2013.
APA
Zhou, X., & Wang, X. (2013). Role of microRNAs in chronic lymphocytic leukemia (Review) . Molecular Medicine Reports, 8, 719-725. https://doi.org/10.3892/mmr.2013.1599
MLA
Zhou, X., Wang, X."Role of microRNAs in chronic lymphocytic leukemia (Review) ". Molecular Medicine Reports 8.3 (2013): 719-725.
Chicago
Zhou, X., Wang, X."Role of microRNAs in chronic lymphocytic leukemia (Review) ". Molecular Medicine Reports 8, no. 3 (2013): 719-725. https://doi.org/10.3892/mmr.2013.1599
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