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2014-January Volume 9 Issue 1

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Article

Berberine enhances chemosensitivity to irinotecan in colon cancer via inhibition of NF‑κB

  • Authors:
    • Meiling Yu
    • Xuhui Tong
    • Benquan Qi
    • Hongdang Qu
    • Shuying Dong
    • Binbin Yu
    • Naiju Zhang
    • Nan Tang
    • Lingzhi Wang
    • Cuiling Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, The First Affiliated Hospital of Bengbu Medical College, Anhui, Bengbu 233004, P.R. China, Faculty of Pharmacy, Bengbu Medical College, Anhui, Bengbu 233030, P.R. China, Department of Pharmacy, Guangdong Medical College, Dongguan, Guangdong 523808, P.R. China, Department of Anaesthesia, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, P.R. China
  • Pages: 249-254
    |
    Published online on: October 29, 2013
       https://doi.org/10.3892/mmr.2013.1762
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Abstract

Previous studies have shown that irinotecan (CPT‑11) impairs chemotherapy‑induced apoptosis by activating nuclear factor‑κB (NF‑κB) and a number of strategies have been employed to augment chemosensitivity through the suppression of NF‑κB activation. Berberine, a botanical alkaloid, was reported to enhance chemosensitivity to 5‑fluorouracil and doxorubicin by suppressing NF‑κB activation. In the present study, the effect of berberine on CPT‑11‑induced apoptosis was investigated through the inhibition of NF‑κB. Inhibition of NF‑κB activation by p65 small interfering RNA was shown to potentiate apoptosis induced by CPT‑11. Berberine suppressed CPT‑11‑induced NF‑κB activation in a dose‑dependent manner and enhanced chemosensitivity to CPT‑11 by downregulating NF‑κB activation of antiapoptotic genes, c‑IAP1, c‑IAP2, survivin and Bcl‑xL. The current observations indicate that berberine inhibits NF‑κB activation and may be used to enhance CPT‑11‑induced apoptosis in colon cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Yu M, Tong X, Qi B, Qu H, Dong S, Yu B, Zhang N, Tang N, Wang L, Zhang C, Zhang C, et al: Berberine enhances chemosensitivity to irinotecan in colon cancer via inhibition of NF‑κB. Mol Med Rep 9: 249-254, 2014.
APA
Yu, M., Tong, X., Qi, B., Qu, H., Dong, S., Yu, B. ... Zhang, C. (2014). Berberine enhances chemosensitivity to irinotecan in colon cancer via inhibition of NF‑κB. Molecular Medicine Reports, 9, 249-254. https://doi.org/10.3892/mmr.2013.1762
MLA
Yu, M., Tong, X., Qi, B., Qu, H., Dong, S., Yu, B., Zhang, N., Tang, N., Wang, L., Zhang, C."Berberine enhances chemosensitivity to irinotecan in colon cancer via inhibition of NF‑κB". Molecular Medicine Reports 9.1 (2014): 249-254.
Chicago
Yu, M., Tong, X., Qi, B., Qu, H., Dong, S., Yu, B., Zhang, N., Tang, N., Wang, L., Zhang, C."Berberine enhances chemosensitivity to irinotecan in colon cancer via inhibition of NF‑κB". Molecular Medicine Reports 9, no. 1 (2014): 249-254. https://doi.org/10.3892/mmr.2013.1762
Copy and paste a formatted citation
x
Spandidos Publications style
Yu M, Tong X, Qi B, Qu H, Dong S, Yu B, Zhang N, Tang N, Wang L, Zhang C, Zhang C, et al: Berberine enhances chemosensitivity to irinotecan in colon cancer via inhibition of NF‑κB. Mol Med Rep 9: 249-254, 2014.
APA
Yu, M., Tong, X., Qi, B., Qu, H., Dong, S., Yu, B. ... Zhang, C. (2014). Berberine enhances chemosensitivity to irinotecan in colon cancer via inhibition of NF‑κB. Molecular Medicine Reports, 9, 249-254. https://doi.org/10.3892/mmr.2013.1762
MLA
Yu, M., Tong, X., Qi, B., Qu, H., Dong, S., Yu, B., Zhang, N., Tang, N., Wang, L., Zhang, C."Berberine enhances chemosensitivity to irinotecan in colon cancer via inhibition of NF‑κB". Molecular Medicine Reports 9.1 (2014): 249-254.
Chicago
Yu, M., Tong, X., Qi, B., Qu, H., Dong, S., Yu, B., Zhang, N., Tang, N., Wang, L., Zhang, C."Berberine enhances chemosensitivity to irinotecan in colon cancer via inhibition of NF‑κB". Molecular Medicine Reports 9, no. 1 (2014): 249-254. https://doi.org/10.3892/mmr.2013.1762
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