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2014-January Volume 9 Issue 1

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Article

Basic fibroblast growth factor increases the transplantation‑mediated therapeutic effect of bone mesenchymal stem cells following traumatic brain injury

  • Authors:
    • Yang Liu
    • Xi‑Cai Yi
    • Geng Guo
    • Qian‑Fa Long
    • Xiao‑An Wang
    • Jun  Zhong
    • Wei‑Ping Liu
    • Zhou Fei
    • Dong‑Mei Wang
    • Jun Liu
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, The Third Hospital of Mianyang, Mianyang, Sichuan 621000, P.R. China, Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China, Department of Neurosurgery, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China, Department of Neurosurgery, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, P.R. China
  • Pages: 333-339
    |
    Published online on: November 15, 2013
       https://doi.org/10.3892/mmr.2013.1803
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Abstract

Basic fibroblast growth factor (bFGF) has proven useful for neural stem and progenitor cells during the transplantation‑mediated therapeutic effect of bone mesenchymal stem cells (BMSCs). Endogenous bFGF expression levels increase during brain development and gradually diminish with aging. To date, few studies have been conducted on exogenous bFGF promoting BMSC transplantation‑mediated functional recovery in adult rats following traumatic brain injury (TBI). The results of the present study showed that BMSCs in the TBI cortex and dentate gyrus showed differentiation along the glial and neuronal lines, which are possibly enhanced by bFGF. The neuronal differentiation rate was not consistent with neurological functional recovery rate over time. bFGF may promote the transplantation‑mediated therapeutic effect of BMSCs more significantly and rapidly in rats following TBI, with a small proportion of differentiated neurons. In conclusion, exogenous bFGF functions as a booster of the transplantation‑mediated therapeutic effect of BMSCs following TBI.
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1 

Li Y, Chen J, Chen XG, et al: Human marrow stromal cell therapy for stroke in rat: neurotrophins and functional recovery. Neurology. 59:514–523. 2002. View Article : Google Scholar : PubMed/NCBI

2 

Lu D, Li Y, Mahmood A, Wang L, Rafiq T and Chopp M: Neural and marrow derived stromal cell sphere transplantation in a rat model of traumatic brain injury. J Neurosurg. 97:935–940. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Lu D, Li Y, Wang L, Chen J, Mahmood A and Chopp M: Intraarterial administration of marrow stromal cells in a rat model of traumatic brain injury. J Neurotrauma. 18:813–819. 2001. View Article : Google Scholar : PubMed/NCBI

4 

Sanchez-Ramos J, Song S, Cardozo-Pelaez F, et al: Adult bone marrow stromal cells differentiate into neural cells in vitro. Exp Neurol. 164:247–256. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Brundin P, Karlsson J, Emgård M, et al: Improving the survival of grafted dopaminergic neurons: a review over current approaches. Cell Transplant. 9:179–195. 2000.PubMed/NCBI

6 

Wagner JP, Black IB and DiCicco-Bloom E: Stimulation of neonatal and adult brain neurogenesis by subcutaneous injection of basic fibroblast growth factor. J Neurosci. 19:6006–6016. 1999.PubMed/NCBI

7 

Ramirez JJ, Finklestein SP, Keller J, Abrams W, George MN and Parakh T: Basic fibroblast growth factor enhances axonal sprouting after cortical injury in rats. Neuroreport. 10:1201–1204. 1999. View Article : Google Scholar : PubMed/NCBI

8 

Yang H, Xia Y, Lu SQ, Soonq TW and Feng ZW: Basic fibroblast growth factor-induced neuronal differentiation of mouse bone marrow stromal cells requires FGFR-1, MAPK/ERK, and transcription factor AP-1. J Biol Chem. 283:5287–5295. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Caday CG, Klagsbrun M, Fanning PJ, Mirzabegian A and Finklestein SP: Fibroblast growth factor (FGF) levels in the developing rat brain. Brain Res Dev Brain Res. 52:241–246. 1990. View Article : Google Scholar : PubMed/NCBI

10 

Shetty AK, Hattiangady B and Shetty GA: Stem/progenitor cell proliferation factors FGF-2, IGF-1, and VEGF exhibit early decline during the course of aging in the hippocampus: role of astrocytes. Glia. 51:173–186. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Jiang Y, Jahagirdar BN, Reinhardt RL, et al: Pluripotency of mesenchymal stem cells derived from adult marrow. Nature. 418:41–49. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Feeney DM, Boyeson MG, Linn RT, Murray HM and Dail WG: Responses to cortical injury: I. Methodology and local effects of contusions in the rat. Brain Res. 211:67–77. 1981. View Article : Google Scholar : PubMed/NCBI

13 

Kawamata T, Dietrich WD, Schallert T, et al: Intracisternal basic fibroblast growth factor enhances functional recovery and up-regulates the expression of a molecular marker of neuronal sprouting following focal cerebral infarction. Proc Natl Acad Sci USA. 94:8179–8184. 1997. View Article : Google Scholar

14 

Jin K, Sun Y, Xie L, et al: Neurogenesis and aging: FGF-2 and HB-EGF restore neurogenesis in hippocampus and subventricular zone of aged mice. Aging Cell. 2:175–183. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Raballo R, Rhee J, Lyn-Cook R, Leckman JF, Schwartz ML and Vaccarino FM: Basic fibroblast growth factor (Fgf2) is necessary for cell proliferation and neurogenesis in the developing cerebral cortex. J Neurosci. 20:5012–5023. 2000.PubMed/NCBI

16 

Monfils MH, Driscoll I, Vavrek R, Kolb B and Fouad K: FGF-2-induced functional improvement from neonatal motor cortex injury via corticospinal projections. Exp Brain Res. 185:453–460. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Lu D, Mahmood A, Wang L, Li Y, Lu M and Chopp M: Adult bone marrow stromal cells administered intravenously to rats after traumatic brain injury migrate into brain and improve neurological outcome. Neuroreport. 12:559–563. 2001. View Article : Google Scholar

18 

Mahmood A, Lu D, Lu M and Chopp M: Treatment of traumatic brain injury in adult rats with intravenous administration of human bone marrow stromal cells. Neurosurgery. 53:697–703. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Mahmood A, Lu D, Wang L, Li Y, Lu M and Chopp M: Treatment of traumatic brain injury in female rats with intravenous administration of bone marrow stromal cells. Neurosurgery. 49:1196–1204. 2001.PubMed/NCBI

20 

Bondanelli M, Ambrosio MR, Margutti A, et al: Evidence for integrity of the growth hormone/insulin-like growth factor-1 axis in patients with severe head trauma during rehabilitation. Metabolism. 51:1363–1369. 2002. View Article : Google Scholar : PubMed/NCBI

21 

Winter CD, Pringle AK, Clough GF and Church MK: Raised parenchymal interleukin-6 levels correlate with improved outcome after traumatic brain injury. Brain. 127:315–320. 2004. View Article : Google Scholar : PubMed/NCBI

22 

McIntosh TK, Saatman KE, Raghupathi R, et al: The Dorothy Russel Memorial Lecture. The molecular and cellular sequelae of experimental traumatic brain injury: pathogenetic mechanisms. Neuropathol Appl Neurobiol. 24:251–267. 1998. View Article : Google Scholar

23 

McKay R: Stem cells in the central nervous system. Science. 276:66–71. 1997. View Article : Google Scholar : PubMed/NCBI

24 

Ourednik J and Ourednik V: Graft-induced plasticity in the mammalian host CNS. Cell Transplant. 13:307–318. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Bracken MB, Shepard MJ, Holford TR, et al: Administration of methylprednisolone for 24 to 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. Results of the third national acute spinal cord injury randomized controlled trial. National Acute Spinal Cord Injury Study. JAMA. 277:1597–1604. 1997.

26 

Bracken MB, Shepard MJ, Holford TR, et al: Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow-up. Results of the third National Acute Spinal Cord Injury randomized controlled trial. J Neurosurg. 89:699–706. 1998.

27 

Liau LM, Bergsherder M and Becker DP: Pathology and pathophysiology of head injury. Neurological Surgery. Youmans JR: 4th edition. WB Saunders; Philadelphia: pp. 1549–1594. 1996

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Copy and paste a formatted citation
Spandidos Publications style
Liu Y, Yi XC, Guo G, Long QF, Wang XA, Zhong J, Liu WP, Fei Z, Wang DM, Liu J, Liu J, et al: Basic fibroblast growth factor increases the transplantation‑mediated therapeutic effect of bone mesenchymal stem cells following traumatic brain injury. Mol Med Rep 9: 333-339, 2014.
APA
Liu, Y., Yi, X., Guo, G., Long, Q., Wang, X., Zhong, J. ... Liu, J. (2014). Basic fibroblast growth factor increases the transplantation‑mediated therapeutic effect of bone mesenchymal stem cells following traumatic brain injury. Molecular Medicine Reports, 9, 333-339. https://doi.org/10.3892/mmr.2013.1803
MLA
Liu, Y., Yi, X., Guo, G., Long, Q., Wang, X., Zhong, J., Liu, W., Fei, Z., Wang, D., Liu, J."Basic fibroblast growth factor increases the transplantation‑mediated therapeutic effect of bone mesenchymal stem cells following traumatic brain injury". Molecular Medicine Reports 9.1 (2014): 333-339.
Chicago
Liu, Y., Yi, X., Guo, G., Long, Q., Wang, X., Zhong, J., Liu, W., Fei, Z., Wang, D., Liu, J."Basic fibroblast growth factor increases the transplantation‑mediated therapeutic effect of bone mesenchymal stem cells following traumatic brain injury". Molecular Medicine Reports 9, no. 1 (2014): 333-339. https://doi.org/10.3892/mmr.2013.1803
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Y, Yi XC, Guo G, Long QF, Wang XA, Zhong J, Liu WP, Fei Z, Wang DM, Liu J, Liu J, et al: Basic fibroblast growth factor increases the transplantation‑mediated therapeutic effect of bone mesenchymal stem cells following traumatic brain injury. Mol Med Rep 9: 333-339, 2014.
APA
Liu, Y., Yi, X., Guo, G., Long, Q., Wang, X., Zhong, J. ... Liu, J. (2014). Basic fibroblast growth factor increases the transplantation‑mediated therapeutic effect of bone mesenchymal stem cells following traumatic brain injury. Molecular Medicine Reports, 9, 333-339. https://doi.org/10.3892/mmr.2013.1803
MLA
Liu, Y., Yi, X., Guo, G., Long, Q., Wang, X., Zhong, J., Liu, W., Fei, Z., Wang, D., Liu, J."Basic fibroblast growth factor increases the transplantation‑mediated therapeutic effect of bone mesenchymal stem cells following traumatic brain injury". Molecular Medicine Reports 9.1 (2014): 333-339.
Chicago
Liu, Y., Yi, X., Guo, G., Long, Q., Wang, X., Zhong, J., Liu, W., Fei, Z., Wang, D., Liu, J."Basic fibroblast growth factor increases the transplantation‑mediated therapeutic effect of bone mesenchymal stem cells following traumatic brain injury". Molecular Medicine Reports 9, no. 1 (2014): 333-339. https://doi.org/10.3892/mmr.2013.1803
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