Interleukin-11 induces the expression of matrix metalloproteinase 13 in gastric cancer SCH cells partly via the PI3K-AKT and JAK-STAT3 pathways

Retraction in: /10.3892/mmr.2015.4107

  • Authors:
    • Gongli Yang
    • Feng Ma
    • Muxiao Zhong
    • Lin Fang
    • Yao Peng
    • Xiaoming Xin
    • Jietao Zhong
    • Wei Zhu
    • Yali Zhang
  • View Affiliations

  • Published online on: February 6, 2014     https://doi.org/10.3892/mmr.2014.1932
  • Pages: 1371-1375
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Abstract

Interleukin (IL)-11 is expressed in the majority of gastric carcinomas and has been associated with an aggressive phenotype and poor prognosis of gastric adenocarcinoma. Matrix metalloproteinase (MMP)-13 has been detected in numerous invasive malignant tumor types and exhibits a broad spectrum of activities on connective tissue components. In this study, we investigated whether IL-11 affects the expression of MMP-13 in human gastric cancer cells, as well as the underlying mechanism. Using western blot assays, we investigated the effect of recombinant human (rh) IL-11 on the expression of MMP-13 in gastric carcinoma cell lines. Using the PI3K inhibitor wortmannin and RNA interference to target the STAT3 gene, we investigated the effects of PI3K inhibition and/or STAT3 depletion on the expression of the MMP-13 protein. Results showed that IL-11 induced MMP-13 expression in a time- and concentration-dependent manner in SCH cells. IL-11 activated PI3K-AKT and JAK-STAT3 signal transduction. Wortmannin and depletion of STAT3 by means of small interfering RNA (siRNA) synergistically reduced the expression of MMP-13. These findings suggested that IL-11 induces the expression of MMP-13 in gastric cancer SCH cells partly via the PI3K-AKT and JAK-STAT3 pathways.

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2014-April
Volume 9 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Yang G, Ma F, Zhong M, Fang L, Peng Y, Xin X, Zhong J, Zhu W and Zhang Y: Interleukin-11 induces the expression of matrix metalloproteinase 13 in gastric cancer SCH cells partly via the PI3K-AKT and JAK-STAT3 pathways Retraction in /10.3892/mmr.2015.4107. Mol Med Rep 9: 1371-1375, 2014.
APA
Yang, G., Ma, F., Zhong, M., Fang, L., Peng, Y., Xin, X. ... Zhang, Y. (2014). Interleukin-11 induces the expression of matrix metalloproteinase 13 in gastric cancer SCH cells partly via the PI3K-AKT and JAK-STAT3 pathways Retraction in /10.3892/mmr.2015.4107. Molecular Medicine Reports, 9, 1371-1375. https://doi.org/10.3892/mmr.2014.1932
MLA
Yang, G., Ma, F., Zhong, M., Fang, L., Peng, Y., Xin, X., Zhong, J., Zhu, W., Zhang, Y."Interleukin-11 induces the expression of matrix metalloproteinase 13 in gastric cancer SCH cells partly via the PI3K-AKT and JAK-STAT3 pathways Retraction in /10.3892/mmr.2015.4107". Molecular Medicine Reports 9.4 (2014): 1371-1375.
Chicago
Yang, G., Ma, F., Zhong, M., Fang, L., Peng, Y., Xin, X., Zhong, J., Zhu, W., Zhang, Y."Interleukin-11 induces the expression of matrix metalloproteinase 13 in gastric cancer SCH cells partly via the PI3K-AKT and JAK-STAT3 pathways Retraction in /10.3892/mmr.2015.4107". Molecular Medicine Reports 9, no. 4 (2014): 1371-1375. https://doi.org/10.3892/mmr.2014.1932