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Article

Suppression of graft-versus-host disease and retention of graft-versus-tumour reaction by murine genetically engineered dendritic cells following bone marrow transplantation

  • Authors:
    • Yihong Huang
    • Saran Feng
    • Yujie Xu
    • Wanru Chen
    • Shuhua Wang
    • Depeng Li
    • Zhenyu Li
    • Qunxian Lu
    • Xiuying Pan
    • Kailin Xu
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, The Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu 221002, P.R. China, Department of Hematology, Shandong Provincial Qianfoshan Hospital, Jinan, Shandong 250014, P.R. China
  • Pages: 3820-3827
    |
    Published online on: December 22, 2014
       https://doi.org/10.3892/mmr.2014.3123
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Abstract

The effect of infusion of lentiviral vector‑mediated, genetically engineered dendritic cells (DCs) following allogeneic bone marrow transplantation (allo‑BMT) on graft‑versus‑host disease (GVHD) and graft‑versus‑leukemia (GVL) was investigated in a mouse model. Lentivirus‑mediated expression of soluble tumor necrosis factor receptor 1 (sTNFR1) converted immature DCs (imDCs) from BABL/c mice into engineered DCs in vitro. An EL4 leukemia allo‑BMT model of BABL/c to C57BL/6 mice was established. Engineered DCs with donor bone marrow cells and splenocytes were subsequently transplanted into myeloablatively irradiated recipients. The average survival duration in the sTNFR1‑ and pXZ9‑imDC groups was significantly prolonged compared with that of the allo‑BMT group (P<0.05). Mild histological changes in GVHD or leukemia were observed in the recipients in the sTNFR1‑imDC group and clinical GVHD scores in this group were significantly decreased compared with those of the transplantation and pXZ9‑imDC groups. Serum interferon‑γ levels were decreased in the pXZ9‑imDC and sTNFR1‑imDC groups compared with those in the allo‑BMT group (P<0.05), with the reduction being more significant in the sTNFR1‑imDC group (P<0.05). Serum interleukin‑4 expression levels were decreased in the allo‑BMT group, but gradually increased in the pXZ9‑imDC and sTNFR1‑imDC groups (P<0.05). Co‑injection of donor genetically‑engineered imDCs was able to efficiently protect recipient mice from lethal GVHD while preserving GVL effects during allo‑BMT.
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View References

1 

Mielcarek M, Storer B, Martin PJ, Forman SJ, Negrin RS, Flowers ME, Inamoto Y, Chauncey TR, Storb R, Appelbaum FR and Bensinger WI: Long-term outcomes after transplantation of HLA-identical related G-CSF-mobilized peripheral blood mononuclear cells versus bone marrow. Blood. 119:2675–2678. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Morecki S, Yacovlev E, Gelfand Y, Shabat Y and Slavin S: Induction of graft-versus-leukemia (GVL) effect without graft-versus-host disease (GVHD) by pretransplant donor treatment with immunomodulators. Biol Blood Marrow Transplant. 15:406–415. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Edinger M, Powrie F and Chakraverty R: Regulatory mechanisms in graft-versus- host response. Biol Blood Marrow Transplant. 15(1 Suppl): 2–6. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Huang Y, Feng S, Tang R, Du B, Xu K and Pan X: Efficacy of pretreatment of allografts with methoxypolyethylene glycol-succinimidyl-propionic acid ester in combination with an anti-OX40L monoclonal antibody in relieving graft-versus-host disease in mice. Int J Hematol. 92:609–616. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Sordi V and Piemonti L: Therapeutic plasticity of stem cells and allograft tolerance. Cytotherapy. 13:647–660. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Zhou F, Ciric B, Zhang GX and Rostami A: Immune tolerance induced by intravenous transfer of immature dendritic cells via up-regulating numbers of suppressive IL-10(+) IFN-γ(+)-producing CD4(+) T cells. Immunol Res. 56:1–8. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Cools N, Van Tendeloo VF, Smits EL, Lenjou M, Nijs G, Van Bockstaele DR, Berneman ZN and Ponsaerts P: Immunosuppression induced by immature dendritic cells is mediated by TGF-beta/IL-10 double-positive CD4+ regulatory T cells. J Cell Mol Med. 12:690–700. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Sun X, Jones HP, Dobbs N, Bodhankar S and Simecka JW: Dendritic cells are the major antigen presenting cells in inflammatory lesions of murine Mycoplasma respiratory disease. PLoS One. 8:e559842013. View Article : Google Scholar : PubMed/NCBI

9 

Maldonado RA and von Andrian UH: How tolerogenic dendritic cells induce regulatory T cells. Adv Immunol. 108:111–165. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Fukaya T, Takagi H, Taya H and Sato K: DCs in immune tolerance in steady-state conditions. Methods Mol Biol. 677:113–126. 2011. View Article : Google Scholar

11 

Trevejo JM, Marino MW, Philpott N, Josien R, Richards EC, Elkon KB and Falck-Pedersen E: TNF-α-dependent maturation of local dendritic cells is critical for activating the adaptive immune response to virus infection. Proc Natl Acad Sci USA. 98:12162–12167. 2001. View Article : Google Scholar

12 

Kleijwegt FS, Laban S, Duinkerken G, Joosten AM, Zaldumbide A, Nikolic T and Roep BO: Critical role for TNF in the induction of human antigen-specific regulatory T cells by tolerogenic dendritic cells. J Immunol. 185:1412–1418. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Jin JO, Park HY, Xu Q, Park JI, Zvyagintseva T, Stonik VA and Kwak JY: Ligand of scavenger receptor class A indirectly induces maturation of human blood dendritic cells via production of tumor necrosis factor-alpha. Blood. 113:5839–5847. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Bosè F, Raeli L, Garutti C, et al: Dual role of anti-TNF therapy: enhancement of TCR-mediated T cell activation in peripheral blood and inhibition of inflammation in target tissues. Clin Immunol. 139:164–176. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Baldwin HM, Ito-Ihara T, Isaacs JD and Hilkens CM: Tumour necrosis factor alpha blockade impairs dendritic cell survival and function in rheumatoid arthritis. Ann Rheum Dis. 69:1200–1207. 2010. View Article : Google Scholar

16 

Rossol M, Meusch U, Pierer M, Kaltenhäuser S, Häntzschel H, Hauschildt S and Wagner U: Interaction between transmembrane TNF and TNFR1/2 mediates the activation of monocytes by contact with T cells. J Immunol. 179:4239–4248. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Yi HJ and Lu GX: Adherent and non-adherent dendritic cells are equivalently qualified in GM-CSF, IL-4 and TNF-α culture system. Cell Immunol. 277:44–48. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Xia Y, Dai J, Lu P, Huang Y, Zhu Y and Zhang X: Distinct effect of CD40 and TNF-signaling on the chemokine/chemokine receptor expression and function of the human monocyte-derived dendritic cells. Cell Mol Immunol. 5:121–131. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Huang YH, Chao YL, Tang RX, Wang SH, Zeng LY, Chen C, Pan XY and Xu KL: Lentivirus-mediated soluble tumor necrosis factor receptor 1 expression in mouse bone marrow-derived immature dendritic cells. J Clin Rehabil Tissue Eng Res. 14:941–946. 2010.

20 

Cao J, Chen C, Zeng L, Li L, Li Z and Xu K: Engineered regulatory T cells prevent graft-versus-host disease while sparing the graft-versus-leukemia effect after bone marrow transplantation. Leuk Res. 34:1374–1382. 2010. View Article : Google Scholar

21 

Cooke KR, Kobzik L, Martin TR, Brewer J, Delmonte J Jr, Crawford JM and Ferrara JL: An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin. Blood. 88:3230–3239. 1996.PubMed/NCBI

22 

Asai O, Longo DL, Tian ZG, Hornung RL, Taub DD, Ruscetti FW and Murphy WJ: Suppression of graft-versus-host disease and amplification of graft-versus-tumor effects by activated natural killer cells after allogeneic bone marrow transplantation. J Clin Invest. 101:1835–1842. 1998. View Article : Google Scholar : PubMed/NCBI

23 

Sun K, Wilkins DE, Anver MR, Sayers TJ, Panoskaltsis-Mortari A, Blazar BR, Welniak LA and Murphy WJ: Differential effects of proteasome inhibition by bortezomib on murine acute graft-versus-host disease (GVHD): delayed administration of bortezomib results in increased GVHD-dependent gastrointestinal toxicity. Blood. 106:3293–3299. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Appelbaum FR: Haematopoietic cell transplantation as immunotherapy. Nature. 411:385–389. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Konuma T, Kato S, Ooi J, Oiwa-Monna M, Kawamata T, Tojo A and Takahashi S: Comparable long-term outcome of unrelated cord blood transplantation with related bone marrow or peripheral blood stem cell transplantation in patients aged 45 years or older with hematologic malignancies after myeloablative conditioning. Biol Blood Marrow Transplant. 20:1150–1155. 2014. View Article : Google Scholar : PubMed/NCBI

26 

van Besien K: Allogeneic transplantation for AML and MDS: GVL versus GVHD and disease recurrence. Hematology Am Soc Hematol Educ Program. 2013:56–62. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Sinkovics JG: Antileukemia and antitumor effects of the graft-versus-host disease: a new immunovirological approach. Acta Microbiol Immunol Hung. 57:253–347. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Kim HJ, Min WS, Cho BS, Eom KS, Kim YJ, Min CK, Lee S, Cho SG, Jin JY, Lee JW and Kim CC: Successful prevention of acute graft-versus-host disease using low-dose antithymocyte globulin after mismatched, unrelated, hematopoietic stem cell transplantation for acute myelogenous leukemia. Biol Blood Marrow Transplant. 15:704–717. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Capitini CM, Herby S, Milliron M, Anver MR, Mackall CL and Fry TJ: Bone marrow deficient in IFN-{gamma} signaling selectively reverses GVHD-associated immunosuppression and enhances a tumor-specific GVT effect. Blood. 113:5002–5009. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Chorny A, Gonzalez-Rey E, Fernandez-Martin A, Ganea D and Delgado M: Vasoactive intestinal peptide induces regulatory dendritic cells that prevent acute graft-versus-host disease while maintaining the graft-versus-tumor response. Blood. 107:3787–3794. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Stenger EO, Turnquist HR, Mapara MY and Thomson AW: Dendritic cells and regulation of graft-versus-host disease and graft-versus-leukemia activity. Blood. 119:5088–5103. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Semple K, Yu Y, Wang D, Anasetti C and Yu XZ: Efficient and selective prevention of GVHD by antigen-specific induced Tregs via linked-suppression in mice. Biol Blood Marrow Transplant. 17:309–318. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Toubai T, Mathewson N and Reddy P: The role of dendritic cells in graft-versus-tumor effect. Front Immunol. 5:662014. View Article : Google Scholar : PubMed/NCBI

34 

Sun W, Wang Q, Zhang L, Pan J, Zhang M, Lu G, Yao H, Wang J and Cao X: TGF-beta(1) gene modified immature dendritic cells exhibit enhanced tolerogenicity but induce allograft fibrosis in vivo. J Mol Med (Berl). 80:514–523. 2002. View Article : Google Scholar

35 

Sela U, Olds P, Park A, Schlesinger SJ and Steinman RM: Dendritic cells induce antigen specific regulatory T cells that prevent graft versus host disease and persist in mice. J Exp Med. 208:2489–2496. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Yang YG, Sergio JJ, Pearson DA, Szot GL, Shimizu A and Sykes M: Interleukin-12 preserves the graft-versus-leukemia effect of allogeneic CD8 T cells while inhibiting CD4-dependent graft-versus-host disease in mice. Blood. 90:4651–4660. 1997.PubMed/NCBI

37 

Mapara MY and Sykes M: Induction of mixed vs full chimerism to potentiate GVL effects after bone-marrow transplantation. Methods Mol Med. 109:469–474. 2005.

38 

Li YJ, Cao J, Chen C, et al: Establishment and identification of mouse lymphoma cell line EL4 expressing red fluorescent protein. J Exp Hematol. 18:107–110. 2010.(In Chinese).

39 

Ball LM and Egeler RM; EBMT Paediatric Working Party. Acute GvHD: pathogenesis and classification. Bone Marrow Transplant. 41(Suppl 2): S58–S64. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Sun Y, Tawara I, Toubai T and Reddy P: Pathophysiology of acute graft-versus-host disease: recent advances. Transl Res. 150:197–214. 2007. View Article : Google Scholar : PubMed/NCBI

41 

Coghill JM, Sarantopoulos S, Moran TP, Murphy WJ, Blazar BR and Serody JS: Effector CD4+ T cells, the cytokines they generate, and GVHD: something old and something new. Blood. 117:3268–3276. 2011. View Article : Google Scholar : PubMed/NCBI

42 

Li JM, Giver CR, Lu Y, Hossain MS, Akhtari M and Waller EK: Separating graft-versus-leukemia from graft-versus-host disease in allogeneic hematopoietic stem cell transplantation. Immunotherapy. 1:599–621. 2009.

43 

Li X, Yang A, Huang H, et al: Induction of type 2 T helper cell allergen tolerance by IL-10-differentiated regulatory dendritic cells. Am J Respir Cell Mol Biol. 42:190–199. 2010. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Huang Y, Feng S, Xu Y, Chen W, Wang S, Li D, Li Z, Lu Q, Pan X, Xu K, Xu K, et al: Suppression of graft-versus-host disease and retention of graft-versus-tumour reaction by murine genetically engineered dendritic cells following bone marrow transplantation. Mol Med Rep 11: 3820-3827, 2015.
APA
Huang, Y., Feng, S., Xu, Y., Chen, W., Wang, S., Li, D. ... Xu, K. (2015). Suppression of graft-versus-host disease and retention of graft-versus-tumour reaction by murine genetically engineered dendritic cells following bone marrow transplantation. Molecular Medicine Reports, 11, 3820-3827. https://doi.org/10.3892/mmr.2014.3123
MLA
Huang, Y., Feng, S., Xu, Y., Chen, W., Wang, S., Li, D., Li, Z., Lu, Q., Pan, X., Xu, K."Suppression of graft-versus-host disease and retention of graft-versus-tumour reaction by murine genetically engineered dendritic cells following bone marrow transplantation". Molecular Medicine Reports 11.5 (2015): 3820-3827.
Chicago
Huang, Y., Feng, S., Xu, Y., Chen, W., Wang, S., Li, D., Li, Z., Lu, Q., Pan, X., Xu, K."Suppression of graft-versus-host disease and retention of graft-versus-tumour reaction by murine genetically engineered dendritic cells following bone marrow transplantation". Molecular Medicine Reports 11, no. 5 (2015): 3820-3827. https://doi.org/10.3892/mmr.2014.3123
Copy and paste a formatted citation
x
Spandidos Publications style
Huang Y, Feng S, Xu Y, Chen W, Wang S, Li D, Li Z, Lu Q, Pan X, Xu K, Xu K, et al: Suppression of graft-versus-host disease and retention of graft-versus-tumour reaction by murine genetically engineered dendritic cells following bone marrow transplantation. Mol Med Rep 11: 3820-3827, 2015.
APA
Huang, Y., Feng, S., Xu, Y., Chen, W., Wang, S., Li, D. ... Xu, K. (2015). Suppression of graft-versus-host disease and retention of graft-versus-tumour reaction by murine genetically engineered dendritic cells following bone marrow transplantation. Molecular Medicine Reports, 11, 3820-3827. https://doi.org/10.3892/mmr.2014.3123
MLA
Huang, Y., Feng, S., Xu, Y., Chen, W., Wang, S., Li, D., Li, Z., Lu, Q., Pan, X., Xu, K."Suppression of graft-versus-host disease and retention of graft-versus-tumour reaction by murine genetically engineered dendritic cells following bone marrow transplantation". Molecular Medicine Reports 11.5 (2015): 3820-3827.
Chicago
Huang, Y., Feng, S., Xu, Y., Chen, W., Wang, S., Li, D., Li, Z., Lu, Q., Pan, X., Xu, K."Suppression of graft-versus-host disease and retention of graft-versus-tumour reaction by murine genetically engineered dendritic cells following bone marrow transplantation". Molecular Medicine Reports 11, no. 5 (2015): 3820-3827. https://doi.org/10.3892/mmr.2014.3123
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