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Expression of cluster of differentiation-95 and relevant signaling molecules in liver cancer

  • Authors:
    • Xuming Wang
    • Kanglai Wei
    • Qiongguang Zhang
    • Sien  Zeng
    • Jing Lin
    • Li Qiao
    • Lijiang Liu
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Guilin Medical University, Guilin 541001, P.R. China, Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China, State Key Laboratory of Virology, National Laboratory of Antiviral and Tumor of Traditional Chinese Medicine, Institute of Medical Virology, Research Center of Food and Drug Evaluation, School of Medicine, Wuhan University, Wuhan, Hubei 430056, P.R. China, Office of Graduate Student Affairs, Guilin Medical University, Guilin 541001, P.R. China, Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan Economy and Technology Development Zone, Wuhan, Hubei 430056, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 3375-3381
    |
    Published online on: December 22, 2014
       https://doi.org/10.3892/mmr.2014.3129
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Abstract

The present study investigated the protein expression levels of cluster of differentiation (CD)95, caspase‑8, caspase‑3 and poly(ADP‑ribose) polymerase 1 (PARP1) in liver cancer and its association with clinical pathological parameters. The results demonstrated that the expression of CD95 correlated with histological differentiation, liver cirrhosis, lymph node metastasis and distant metastasis (P<0.05), however, no correlations with gender, age, quantity of tumor nodules or T stage were observed (P>0.05). The expression of CD95 was upregulated using a plasmid, which led to an increase in the expression levels of caspase‑8 and caspase‑3 and a decrease in the expression of PARP1. Upregulation of CD95 also promoted the apoptosis of the liver cancer cells. These results indicated that CD95 was associated with liver cancer and promoted the apoptosis of liver cancer cells by caspase‑8, caspase‑3 and PARP1.
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Copy and paste a formatted citation
Spandidos Publications style
Wang X, Wei K, Zhang Q, Zeng S, Lin J, Qiao L and Liu L: Expression of cluster of differentiation-95 and relevant signaling molecules in liver cancer. Mol Med Rep 11: 3375-3381, 2015.
APA
Wang, X., Wei, K., Zhang, Q., Zeng, S., Lin, J., Qiao, L., & Liu, L. (2015). Expression of cluster of differentiation-95 and relevant signaling molecules in liver cancer. Molecular Medicine Reports, 11, 3375-3381. https://doi.org/10.3892/mmr.2014.3129
MLA
Wang, X., Wei, K., Zhang, Q., Zeng, S., Lin, J., Qiao, L., Liu, L."Expression of cluster of differentiation-95 and relevant signaling molecules in liver cancer". Molecular Medicine Reports 11.5 (2015): 3375-3381.
Chicago
Wang, X., Wei, K., Zhang, Q., Zeng, S., Lin, J., Qiao, L., Liu, L."Expression of cluster of differentiation-95 and relevant signaling molecules in liver cancer". Molecular Medicine Reports 11, no. 5 (2015): 3375-3381. https://doi.org/10.3892/mmr.2014.3129
Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, Wei K, Zhang Q, Zeng S, Lin J, Qiao L and Liu L: Expression of cluster of differentiation-95 and relevant signaling molecules in liver cancer. Mol Med Rep 11: 3375-3381, 2015.
APA
Wang, X., Wei, K., Zhang, Q., Zeng, S., Lin, J., Qiao, L., & Liu, L. (2015). Expression of cluster of differentiation-95 and relevant signaling molecules in liver cancer. Molecular Medicine Reports, 11, 3375-3381. https://doi.org/10.3892/mmr.2014.3129
MLA
Wang, X., Wei, K., Zhang, Q., Zeng, S., Lin, J., Qiao, L., Liu, L."Expression of cluster of differentiation-95 and relevant signaling molecules in liver cancer". Molecular Medicine Reports 11.5 (2015): 3375-3381.
Chicago
Wang, X., Wei, K., Zhang, Q., Zeng, S., Lin, J., Qiao, L., Liu, L."Expression of cluster of differentiation-95 and relevant signaling molecules in liver cancer". Molecular Medicine Reports 11, no. 5 (2015): 3375-3381. https://doi.org/10.3892/mmr.2014.3129
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