Integrin αvβ3 is required for cathepsin B-induced hepatocellular carcinoma progression

Xu,Zong‑Zhen; Xiu,Peng; Lv,Ju‑Wei; Wang,Fu‑Hai; Dong,Xiao‑Feng; Liu,Feng; Li,Tao; Li,Jie

doi:10.3892/mmr.2014.3140

Integrin αvβ3 is required for cathepsin B-induced hepatocellular carcinoma progression

Authors:
- Zong‑Zhen Xu
- Peng Xiu
- Ju‑Wei Lv
- Fu‑Hai Wang
- Xiao‑Feng Dong
- Feng Liu
- Tao Li
- Jie Li
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Affiliations: Department of General Surgery, Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China
Published online on: December 30, 2014 https://doi.org/10.3892/mmr.2014.3140
Pages: 3499-3504

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Abstract

The cysteine protease cathepsin B (Cat B) is important in the progression of tumor cells, however, the function and molecular mechanisms of Cat B in hepatocellular carcinoma (HCC) remain to be elucidated. Our previous study demonstrated that integrin αvβ3 regulated the biological behavior of HCC. The present study demonstrated that Cat B was also important in cell proliferation and apoptosis in HCC. Notably, Cat B was observed to activate the phosphoinositide 3‑kinase (PI3K)/Akt signaling pathway to promote HCC proliferation. Furthermore, inhibition of integrin αvβ3 significantly prevented Cat B‑induced activation of PI3K/Akt and the progression of HCC. Thus, the results of the present study suggested the presence of a Cat B/integrin αvβ3/PI3K/Akt axis in the regulation of the progression of HCC.

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