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Article

Integrin αvβ3 is required for cathepsin B-induced hepatocellular carcinoma progression

  • Authors:
    • Zong‑Zhen Xu
    • Peng Xiu
    • Ju‑Wei Lv
    • Fu‑Hai Wang
    • Xiao‑Feng Dong
    • Feng Liu
    • Tao Li
    • Jie Li
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China
  • Pages: 3499-3504
    |
    Published online on: December 30, 2014
       https://doi.org/10.3892/mmr.2014.3140
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Abstract

The cysteine protease cathepsin B (Cat B) is important in the progression of tumor cells, however, the function and molecular mechanisms of Cat B in hepatocellular carcinoma (HCC) remain to be elucidated. Our previous study demonstrated that integrin αvβ3 regulated the biological behavior of HCC. The present study demonstrated that Cat B was also important in cell proliferation and apoptosis in HCC. Notably, Cat B was observed to activate the phosphoinositide 3‑kinase (PI3K)/Akt signaling pathway to promote HCC proliferation. Furthermore, inhibition of integrin αvβ3 significantly prevented Cat B‑induced activation of PI3K/Akt and the progression of HCC. Thus, the results of the present study suggested the presence of a Cat B/integrin αvβ3/PI3K/Akt axis in the regulation of the progression of HCC.
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Copy and paste a formatted citation
Spandidos Publications style
Xu ZZ, Xiu P, Lv JW, Wang FH, Dong XF, Liu F, Li T and Li J: Integrin αvβ3 is required for cathepsin B-induced hepatocellular carcinoma progression. Mol Med Rep 11: 3499-3504, 2015.
APA
Xu, Z., Xiu, P., Lv, J., Wang, F., Dong, X., Liu, F. ... Li, J. (2015). Integrin αvβ3 is required for cathepsin B-induced hepatocellular carcinoma progression. Molecular Medicine Reports, 11, 3499-3504. https://doi.org/10.3892/mmr.2014.3140
MLA
Xu, Z., Xiu, P., Lv, J., Wang, F., Dong, X., Liu, F., Li, T., Li, J."Integrin αvβ3 is required for cathepsin B-induced hepatocellular carcinoma progression". Molecular Medicine Reports 11.5 (2015): 3499-3504.
Chicago
Xu, Z., Xiu, P., Lv, J., Wang, F., Dong, X., Liu, F., Li, T., Li, J."Integrin αvβ3 is required for cathepsin B-induced hepatocellular carcinoma progression". Molecular Medicine Reports 11, no. 5 (2015): 3499-3504. https://doi.org/10.3892/mmr.2014.3140
Copy and paste a formatted citation
x
Spandidos Publications style
Xu ZZ, Xiu P, Lv JW, Wang FH, Dong XF, Liu F, Li T and Li J: Integrin αvβ3 is required for cathepsin B-induced hepatocellular carcinoma progression. Mol Med Rep 11: 3499-3504, 2015.
APA
Xu, Z., Xiu, P., Lv, J., Wang, F., Dong, X., Liu, F. ... Li, J. (2015). Integrin αvβ3 is required for cathepsin B-induced hepatocellular carcinoma progression. Molecular Medicine Reports, 11, 3499-3504. https://doi.org/10.3892/mmr.2014.3140
MLA
Xu, Z., Xiu, P., Lv, J., Wang, F., Dong, X., Liu, F., Li, T., Li, J."Integrin αvβ3 is required for cathepsin B-induced hepatocellular carcinoma progression". Molecular Medicine Reports 11.5 (2015): 3499-3504.
Chicago
Xu, Z., Xiu, P., Lv, J., Wang, F., Dong, X., Liu, F., Li, T., Li, J."Integrin αvβ3 is required for cathepsin B-induced hepatocellular carcinoma progression". Molecular Medicine Reports 11, no. 5 (2015): 3499-3504. https://doi.org/10.3892/mmr.2014.3140
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