|
1
|
Cagle PT, Allen TC, Dacic S, et al:
Revolution in lung cancer: new challenges for the surgical
pathologist. Arch Pathol Lab Med. 135:110–116. 2011.PubMed/NCBI
|
|
2
|
Juergens R and Brahmer J: Targeting the
epidermal growth factor receptor in non-small-cell lung cancer:
who, which, when, and how? Curr Oncol Rep. 9:255–264. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Alberg AJ, Ford JG and Samet JM; American
College of Chest Physicians. Epidemiology of lung cancer: ACCP
evidence-based clinical practice guidelines (2nd edition). Chest.
132(Suppl): 29S–55S. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Gavert N and Ben-Ze’ev A:
Epithelial-mesenchymal transition and the invasive potential of
tumors. Trends Mol Med. 14:199–209. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Thiery JP, Acloque H, Huang RY and Nieto
MA: Epithelial-mesenchymal transitions in development and disease.
Cell. 139:871–890. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Prudkin L, Liu DD, Ozburn NC, et al:
Epithelial-to-mesenchymal transition in the development and
progression of adenocarcinoma and squamous cell carcinoma of the
lung. Mod Pathol. 22:668–678. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Li LP, Lu CH, Chen ZP, et al: Subcellular
proteomics revealed the epithelial-mesenchymal transition phenotype
in lung cancer. Proteomics. 11:429–439. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Wang G, Dong W, Shen H, et al: A
comparison of Twist and E-cadherin protein expression in primary
non-small-cell lung carcinoma and corresponding metastases. Eur J
Cardiothorac Surg. 39:1028–1032. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Pirozzi G, Tirino V, Camerlingo R, et al:
Epithelial to mesenchymal transition by TGFβ-1 induction increases
stemness characteristics in primary non small cell lung cancer cell
line. PLoS One. 6:e215482011. View Article : Google Scholar
|
|
10
|
Soltermann A, Tischler V, Arbogast S, et
al: Prognostic significance of epithelial-mesenchymal and
mesenchymal-epithelial transition protein expression in non-small
cell lung cancer. Clin Cancer Res. 14:7430–7437. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Lee JM, Dedhar S, Kalluri R and Thompson
EW: The epithelial-mesenchymal transition: new insights in
signaling, development, and disease. J Cell Biol. 172:973–981.
2006. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Zhang HJ, Wang HY, Zhang HT, et al:
Transforming growth factor-β1 promotes lung adenocarcinoma invasion
and metastasis by epithelial-to-mesenchymal transition. Mol Cell
Biochem. 355:309–314. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Gialmanidis IP, Bravou V, Amanetopoulou
SG, Varakis J, Kourea H and Papadaki H: Overexpression of hedgehog
pathway molecules and FOXM1 in non-small cell lung carcinomas. Lung
Cancer. 66:64–74. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Stecca B and Ruiz I Altaba A:
Context-dependent regulation of the GLI code in cancer by HEDGEHOG
and non-HEDGEHOG signals. J Mol Cell Biol. 2:84–95. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Aokage K, Ishii G, Ohtaki Y, et al:
Dynamic molecular changes associated with epithelial-mesenchymal
transition and subsequent mesenchymal-epithelial transition in the
early phase of metastatic tumor formation. Int J Cancer.
128:1585–1595. 2011. View Article : Google Scholar
|
|
16
|
Kasai H, Allen JT, Mason RM, Kamimura T
and Zhang Z: TGF-beta1 induces human alveolar epithelial to
mesenchymal cell transition (EMT). Respir Res. 6:562005. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Kim JH, Jang YS, Eom KS, et al:
Transforming growth factor beta1 induces epithelial-to-mesenchymal
transition of A549 cells. J Korean Med Sci. 22:898–904. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Sporn MB: The war on cancer. Lancet.
347:1377–1381. 1996. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Maitah MY, Ali S, Ahmad A, Gadgeel S and
Sarkar FH: Up-regulation of sonic hedgehog contributes to
TGF-β1-induced epithelial to mesenchymal transition in NSCLC cells.
PLoS One. 6:e160682011. View Article : Google Scholar
|
|
20
|
Zhu H and Lo HW: The human
glioma-associated oncogene homolog 1 (GLI1) family of transcription
factors in gene regulation and diseases. Curr Genomics. 11:238–245.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Zheng X, Vittar NB, Gai X, et al: The
transcription factor GLI1 mediates TGFβ1 driven EMT in
hepatocellular carcinoma via a SNAI1-dependent mechanism. PLoS One.
7:e495812012. View Article : Google Scholar
|
|
22
|
Massagué J, Blain SW and Lo RS: TGFbeta
signaling in growth control, cancer, and heritable disorders. Cell.
103:295–309. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Ko H, So Y, Jeon H, Jeong MH, et al:
TGF-β1-induced epithelial-mesenchymal transition and acetylation of
Smad2 and Smad3 are negatively regulated by EGCG in human A549 lung
cancer cells. Cancer Lett. 10:205–213. 2013. View Article : Google Scholar
|
|
24
|
Gunaratne A, Thai BL and Di Guglielmo GM:
Atypical protein kinase C phosphorylates Par6 and facilitates
transforming growth factor β-induced epithelial-to-mesenchymal
transition. Mol Cell Biol. 33:874–886. 2013. View Article : Google Scholar :
|
|
25
|
Liu LC, Tsao TC, Hsu SR, Wang HC, Tsai TC,
Kao JY and Way TD: EGCG inhibits transforming growth
factor-β-mediated epithelial-to-mesenchymal transition via the
inhibition of Smad2 and Erk1/2 signaling pathways in nonsmall cell
lung cancer cells. J Agric Food Chem. 60:9863–9873. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Cao M, Seike M, Soeno C, et al: MiR-23a
regulates TGF-β-induced epithelial-mesenchymal transition by
targeting E-cadherin in lung cancer cells. Int J Oncol. 41:869–875.
2012.PubMed/NCBI
|
|
27
|
Pasca di Magliano M and Hebrok M: Hedgehog
signalling in cancer formation and maintenance. Nat Rev Cancer.
3:903–911. 2003. View
Article : Google Scholar
|
|
28
|
Ruel L, Rodriguez R, Gallet A,
Lavenant-Staccini L and Thérond PP: Stability and association of
Smoothened, Costal2 and Fused with Cubitus interruptus are
regulated by Hedgehog. Nat Cell Biol. 5:907–913. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Wang B, Fallon JF and Beachy PA:
Hedgehog-regulated processing of Gli3 produces an
anterior/posterior repressor gradient in the developing vertebrate
limb. Cell. 100:423–434. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Bai CB, Stephen D and Joyner AL: All mouse
ventral spinal cord patterning by hedgehog is Gli dependent and
involves an activator function of Gli3. Dev Cell. 6:103–115. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Teglund S and Toftgård R: Hedgehog beyond
medulloblastoma and basal cell carcinoma. Biochim Biophys Acta.
1805.181–208. 2010.
|
|
32
|
Katoh Y and Katoh M: Hedgehog target
genes: mechanisms of carcinogenesis induced by aberrant hedgehog
signaling activation. Curr Mol Med. 9:873–886. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Yuan Z, Goetz JA, Singh S, et al: Frequent
requirement of hedgehog signaling in non-small cell lung carcinoma.
Oncogene. 26:1046–1055. 2007. View Article : Google Scholar
|
|
34
|
Yoo YA, Kang MH, Lee HJ, et al: Sonic
hedgehog pathway promotes metastasis and lymphangiogenesis via
activation of Akt, EMT, and MMP-9 pathway in gastric cancer. Cancer
Res. 71:7061–7070. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
LoRusso PM, Rudin CM, Reddy JC, et al:
Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449)
in patients with refractory, locally advanced or metastatic solid
tumors. Clin Cancer Res. 17:2502–2511. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Ruiz I Altaba A, Mas C and Stecca B: The
Gli code: an information nexus regulating cell fate, stemness and
cancer. Trends Cell Biol. 17:438–447. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Chen XF, Zhang HJ, Wang HB, et al:
Transforming growth factor-β1 induces epithelial-to mesenchymal
transition in human lung cancer cells via PI3K/Akt and MEK/Erk1/2
signaling pathways. Mol Biol Rep. 39:3549–3556. 2012. View Article : Google Scholar
|
|
38
|
Yauch RL, Januario T, Eberhard DA, et al:
Epithelial versus mesenchymal phenotype determines in vitro
sensitivity and predicts clinical activity of erlotinib in lung
cancer patients. Clin Cancer Res. 11:8686–8698. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Shintani Y, Okimura A, Sato K, et al:
Epithelial to mesenchymal transition is a determinant of
sensitivity to chemoradiotherapy in non-small cell lung cancer. Ann
Thorac Surg. 92:1794–1804. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Jung JW, Hwang SY, Hwang JS, Oh ES, Park S
and Han IO: Ionising radiation induces changes associated with
epithelial-mesenchymal transdifferentiation and increased cell
motility of A549 lung epithelial cells. Eur J Cancer. 43:1214–1224.
2007. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Zhou YC, Liu JY, Li J, et al: Ionizing
radiation promotes migration and invasion of cancer cells through
transforming growth factor-beta-mediated epithelial-mesenchymal
transition. Int J Radiat Oncol Biol Phys. 81:1530–1537. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Theys J, Jutten B, Habets R, et al:
E-Cadherin loss associated with EMT promotes radioresistance in
human tumor cells. Radiother Oncol. 99:392–397. 2011. View Article : Google Scholar : PubMed/NCBI
|
