Exploring the association between interleukin-1β and its interacting proteins in Alzheimer's disease

Xie,Lushuang; Lai,Yu; Lei,Fang; Liu,Sujuan; Liu,Ran; Wang,Tinghua

doi:10.3892/mmr.2015.3183

Exploring the association between interleukin-1β and its interacting proteins in Alzheimer's disease

Authors:
- Lushuang Xie
- Yu Lai
- Fang Lei
- Sujuan Liu
- Ran Liu
- Tinghua Wang
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Affiliations: Department of Histology and Neurobiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Department of Histology, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610072, P.R. China, Department of Physiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, P.R. China
Published online on: January 12, 2015 https://doi.org/10.3892/mmr.2015.3183
Pages: 3219-3228
Copyright: © Xie et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

Alzheimer's disease (AD) is an age‑associated progressive neurodegenerative disorder which is of clinical concern. The association between the nervous and immune system is defined as an neuroimmunological theory that supports a model of pathology or treatment for AD. Interleukin (IL)‑1β has a pro‑inflammatory function in AD; however, the mechanism of its dysregulation in AD remains unknown. It is therefore of significance to understand the molecular mechanisms of IL‑1β and how it may regulate AD. Proteins, which have been previously reported to be associated with IL‑1β in AD, have been used in the present study as nodes to illustrate a net of protein interaction in Cytoscape. The Kyoto Encyclopedia of Genes and Genomes was used to further analyze the association of these proteins with the pathology of AD. The present study identified and subsequently compared two AD and six IL‑1β pathways with the network produced in Cytoscape. The present study identified important mechanisms in the pathology of AD and constructed two novel networks using Cytoscape.

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