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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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May-2015 Volume 11 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Absence of the first two zinc fingers in BCL6 causes the loss of inhibitory effects on cell growth

  • Authors:
    • Xiaoxing Fu
    • Ying Hao
    • Ying Mao
    • Yanlin Qian
    • Zunlei Qian
    • Ting Li
    • Dacheng He
    • Xueyuan Xiao

  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Beijing Normal University, Beijing 100875, P.R. China
  • Pages: 3828-3833
    |
    Published online on: January 13, 2015
       https://doi.org/10.3892/mmr.2015.3185
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Abstract

BCL6ZF is a novel transcript of BCL6, which lacks the first two zinc fingers of BCL6. It has been established that BCL6 acts as a sequence‑specific transcriptional repressor, however, the functions of BCL6ZF remain undefined. By generating stably overexpressed BCL6 and BCL6ZF in NCI‑H1299 lung cancer cells, it was found that BCL6 suppressed the levels of cell growth associated with impaired G1 phase progression compared with those of the mock control cells. However, the effects of BCL6ZF on cell growth and the cell cycle were negligible. Further study of these results demonstrated that eight genes downstream of BCL6 were markedly downregulated by the overexpression of BCL6, whereas BCL6ZF suppressed only TGFBI, indicating that the loss of the first two zinc fingers caused the loss of the inhibitory effects on cell growth and transcriptional repression. In addition, it was determined that the BCL6ZF protein was not degraded as easily as BCL6 protein by the ubiquitin/proteasome pathway, implying that the loss of the first two zinc fingers changes the three‑dimensional structure of BCL6ZF. The results demonstrated that BCL6 and BCL6ZF had different role in H1299 cells both in vitro and in vivo. The loss of its inhibitory effects on cell growth and transcriptional repressions.

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Copy and paste a formatted citation
Spandidos Publications style
Fu X, Hao Y, Mao Y, Qian Y, Qian Z, Li T, He D and Xiao X: Absence of the first two zinc fingers in BCL6 causes the loss of inhibitory effects on cell growth. Mol Med Rep 11: 3828-3833, 2015.
APA
Fu, X., Hao, Y., Mao, Y., Qian, Y., Qian, Z., Li, T. ... Xiao, X. (2015). Absence of the first two zinc fingers in BCL6 causes the loss of inhibitory effects on cell growth. Molecular Medicine Reports, 11, 3828-3833. https://doi.org/10.3892/mmr.2015.3185
MLA
Fu, X., Hao, Y., Mao, Y., Qian, Y., Qian, Z., Li, T., He, D., Xiao, X."Absence of the first two zinc fingers in BCL6 causes the loss of inhibitory effects on cell growth". Molecular Medicine Reports 11.5 (2015): 3828-3833.
Chicago
Fu, X., Hao, Y., Mao, Y., Qian, Y., Qian, Z., Li, T., He, D., Xiao, X."Absence of the first two zinc fingers in BCL6 causes the loss of inhibitory effects on cell growth". Molecular Medicine Reports 11, no. 5 (2015): 3828-3833. https://doi.org/10.3892/mmr.2015.3185
Copy and paste a formatted citation
x
Spandidos Publications style
Fu X, Hao Y, Mao Y, Qian Y, Qian Z, Li T, He D and Xiao X: Absence of the first two zinc fingers in BCL6 causes the loss of inhibitory effects on cell growth. Mol Med Rep 11: 3828-3833, 2015.
APA
Fu, X., Hao, Y., Mao, Y., Qian, Y., Qian, Z., Li, T. ... Xiao, X. (2015). Absence of the first two zinc fingers in BCL6 causes the loss of inhibitory effects on cell growth. Molecular Medicine Reports, 11, 3828-3833. https://doi.org/10.3892/mmr.2015.3185
MLA
Fu, X., Hao, Y., Mao, Y., Qian, Y., Qian, Z., Li, T., He, D., Xiao, X."Absence of the first two zinc fingers in BCL6 causes the loss of inhibitory effects on cell growth". Molecular Medicine Reports 11.5 (2015): 3828-3833.
Chicago
Fu, X., Hao, Y., Mao, Y., Qian, Y., Qian, Z., Li, T., He, D., Xiao, X."Absence of the first two zinc fingers in BCL6 causes the loss of inhibitory effects on cell growth". Molecular Medicine Reports 11, no. 5 (2015): 3828-3833. https://doi.org/10.3892/mmr.2015.3185
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